rheb
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  • Official Full Name
  • Ras homolog enriched in brain
  • Background
  • Rheb (Ras homolog enriched in brain) is an evolutionarily conserved member of the Ras family of small GTP-binding proteins that was originally found to be rapidly induced by synaptic activity in the hippocampus following seizure. While it is expressed at relatively high levels in the brain, Rheb is widely expressed in other tissues and may be induced by growth factor stimulation. Similar to other Ras family members, Rheb triggers activation of the Raf-MEK-MAPK pathway. Biochemical and genetic studies suggest that Rheb plays an important role in regulating the insulin/mTOR signaling pathway.
  • Synonyms
  • RHEB; Ras homolog enriched in brain; Ras homolog enriched in brain 2 , RHEB2; GTP-binding protein Rheb; Ras homolog enriched in brain 2; RHEB2; MGC111559
Cat.#:RHEB-1181HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human RHEB Protein, MYC/DDK-tagged
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Cat.#:RHEB-1144HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ras Homolog Enriched In Brain, GST-tagged
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Cat.#:RHEB-2289HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RHEB, His-tagged
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Cat.#:RHEB-31324THTag:His
Source (Host):Species:Human
Product nameRecombinant Human RHEB, His-tagged
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Cat.#:RHEB-31325THTag:T7
Source (Host):Species:Human
Product nameRecombinant Human RHEB, T7 -tagged
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Cat.#:RHEB-31326THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RHEB
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Cat.#:RHEB-384HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Ras Homolog Enriched In Brain, His-tagged
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Cat.#:RHEB-393HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ras Homolog Enriched in Brain, T7-Tagged
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Cat.#:RHEB-521HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human RHEB, His tagged
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Cat.#:RHEB-5032RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat RHEB Protein
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Cat.#:RHEB-3884RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey RHEB Protein, His-tagged
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Cat.#:RHEB-4581ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RHEB
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Cat.#:RHEB-001HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human RHEB cell lysate
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Involved Pathway

RHEB involved in several pathways and played different roles in them. We selected most pathways RHEB participated on our site, such as Phospholipase D signaling pathway, mTOR signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RHEB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Phospholipase D signaling pathway
GAB2; LPAR3; PLCG1; AVPR1B; PLA2G4C; MAPK1; TSC2; TSC1; AKT2; DGKD
mTOR signaling pathway
TSC1; DDIT4; AKT1S1; PIK3R2; RPS6KA2; PRKAA1; CAB39L1; RPS6KA1; RPS6KB1B; TSC2
PIK-Akt signaling pathway
GNB1; GNG12; THBS2; MTCP1; VWF; IFNA1; FGF21; IFNA6; LPAR4; GNG4
AMPK signaling pathway
PFKP; RHEB; SREBF1; CRTC2; PIK3R5; LEPR; PRKAA2; IRS4; CAB39L; PCK1
Insulin signaling pathway
PPP1R3B; PIK3R3B; GRB2A; PRKAG2A; CALM2A; AKT2L; TSC2; PPP1R3CB; RAF1A; FBP1B
Thyroid hormone signaling pathway
PIK3R1; MED27; CCND1; MED30; PDPK1; TSC2; ATP1A3; SRC; MAP2K2; AKT2
Choline metabolism in cancer
DGKA; PIK3CA; PDGFD; RHEB; PDGFA; RAC2; PIP5K1A; MAPK10; NRAS; PIP5K1C

Protein Function

RHEB has several biochemical functions, for example, GTP binding, GTPase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RHEB itself. We selected most functions RHEB had, and list some proteins which have the same functions with RHEB. You can find most of the proteins on our site.
Function
Related Protein
Function GTP binding
Related Protein RHOBTB1; RHOH; GNAZ; RHOAA; TUBB2A; TUBA1L2; RHOQ; SCG5; HRASA; GNA13
Function GTPase activity
Related Protein TUBA7L; EEF1A1; RAB18B; RALAA; TUBA3D; CDC42; RASL10A; ARHGDIB; GNA12A; IFT27
Function metal ion binding
Related Protein CYP2P8; SDF4; LHX1B; CYP2AD2; NT5C3L; PPM1F; ZNF831; BMPR1BB; Adcy4; PHLPP2
Function protein binding
Related Protein ATF6B; MRPL12; TRPV6; ERO1L; TMEM14C; WASH1; AHCYL1; HHIP; Artn; PSMA4
Function protein kinase binding
Related Protein PPP1CC; IRS2; GYS1; BCAR1; THY1; CNPPD1; CAMK2N1; AKAP1; AGTR1A; AP1B1

Interacting Protein

RHEB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RHEB here. Most of them are supplied by our site. Hope this information will be useful for your research of RHEB.
RAF1; EIF1B; MTOR; TRAF2; RPTOR; CREB3; ARIH2; A2M; NCAM1; Traf2; PSEN2; Appl1; Blzf1; ECSIT; pi3p

RHEB Related Articles

Jeon, MT; Nam, JH; et al. In Vivo AAV1 Transduction With hRheb(S16H) Protects Hippocampal Neurons by BDNF Production. MOLECULAR THERAPY 23:445-455(2015).
Wu, D; Chapman, JR; et al. Intestinal Cell Kinase (ICK) Promotes Activation of mTOR Complex 1 (mTORC1) through Phosphorylation of Raptor Thr-908. JOURNAL OF BIOLOGICAL CHEMISTRY 287:12510-12519(2012).