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RLN3

  • Official Full Name

    relaxin 3

  • Overview

    Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In the human there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3. RLN1 and RLN2 share high sequence homology. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. The protein encoded by this gene is a member of the relaxin family. The active form of the encoded protein consists of an A chain and a B chain but their cleavage sites are not definitely described yet. It may play a role in neuropeptide signaling processes.
  • Synonyms

    RLN3; relaxin 3; relaxin 3 (H3); relaxin-3; H3; RXN3; ZINS4; prorelaxin H3; insulin-like 7; insulin-like peptide 7; insulin-like peptide INSL7; insl7;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RLN3-115H Recombinant Human Relaxin 3 E.coli N/A
Human RLN3-341H Recombinant Human RLN3 Protein E.coli N/A
Mouse RLN3-14256M Recombinant Mouse RLN3 Protein Mammalian Cell His
Mouse Rln3-2019M Recombinant Mouse Rln3 Protein, His-tagged E.coli N-His Arg25-Cys141
Mouse RLN3-7623M Recombinant Mouse RLN3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse RLN3-7623M-B Recombinant Mouse RLN3 Protein Pre-coupled Magnetic Beads HEK293
Rat RLN3-5056R Recombinant Rat RLN3 Protein Mammalian Cell His
Rat Rln3-1044R Recombinant Rat Rln3 protein, His-tagged E.coli His Met1~Cys140 (Accession # Q8BFS3)
Rat RLN3-4715R Recombinant Rat RLN3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat RLN3-4715R-B Recombinant Rat RLN3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque RLN3-3905R Recombinant Rhesus monkey RLN3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque RLN3-3722R Recombinant Rhesus Macaque RLN3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque RLN3-3722R-B Recombinant Rhesus Macaque RLN3 Protein Pre-coupled Magnetic Beads HEK293
Chicken RLN3-3798C Recombinant Chicken RLN3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • RLN3 Related Articles

RLN3 involved in several pathways and played different roles in them. We selected most pathways RLN3 participated on our site, such as Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, G alpha (s) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with RLN3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Class A/1 (Rhodopsin-like receptors)NMB;PROKR2;OXTRL;SST;ADORA2B;CCR8;OPN1LW2;UTS2;OPN1SW1
G alpha (i) signalling eventsOXGR1;RGS4;CXCR7B;DRD3;LPAR5A;HCAR1-2;TAS2R13;GPR18;RGS6
G alpha (s) signalling eventsGHRH;RLN3A;ADM;CALCB;ADCYAP1B;CGA;DRD5;CRH;PDE10A
GPCR downstream signalingTAS2R3;OPN4A;NPFF;GCGA;RAMP3;GPR65;CHRM2;HRH3;NPB
GPCR ligand bindingPTH;CHRM5;KISS1;CCL35.1;HEBP1;EDN3;LPAR2B;CCR3;CALCRL
Peptide ligand-binding receptorsSSTR5;PPY;CCL27;CCL35.1;PROK1;GPR37L1;APLN;NPB;OXTRL
Relaxin receptorsINSL3;RLN2;RLN3A;RXFP2;RLN3;INSL5
Signal TransductionPDK3B;ARHGAP6;RLN1;C;OR10A5;TAAR1;OR2AP1;CCL35.2;CCK

RLN3 has several biochemical functions, for example, G-protein coupled receptor binding, hormone activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RLN3 itself. We selected most functions RLN3 had, and list some proteins which have the same functions with RLN3. You can find most of the proteins on our site.

Function Related Protein
G-protein coupled receptor bindingPSAPL1;RSPO4;AKAP5;HSPA1A;FYN;DNAJA1;ITGB4;HAND2;GNA15.1
hormone activityPRL7B1;ADCYAP1B;PRL2;PRL7C1;APLN;PRL5A1;FNDC5B;GPHB5;TSHB
protein bindingRaet1c;PAXIP1;PAX3;NTHL1;PTH2R;MAGEB4;THEMIS;PNMA2;NINJ1

RLN3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RLN3 here. Most of them are supplied by our site. Hope this information will be useful for your research of RLN3.

RXFP4

Bitto, A; Irrera, N; et al. Relaxin improves multiple markers of wound healing and ameliorates the disturbed healing pattern of genetically diabetic mice. CLINICAL SCIENCE 125:575-585(2013).
Reitemeier, S; Haense, M; et al. Antibody selection for immunocytochemical characterization of the male reproductive system in Psittaciformes. THERIOGENOLOGY 80:597-608(2013).
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