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Rnf216

Official Full Name

ring finger protein 216
Overview

This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known.
Synonyms

RNF216; ring finger protein 216; E3 ubiquitin-protein ligase RNF216; TRIAD3; U7I1; UBCE7IP1; ZIN; triad domain-containing protein 3; zinc finger protein inhibiting NF-kappa-B; ubiquitin-conjugating enzyme 7-interacting protein 1;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
N/A
No tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	RNF216-2282HCL	Recombinant Human RNF216 293 Cell Lysate	HEK293	N/A		Inquiry
Human	RNF216-3625H	Recombinant Human RNF216 protein, GST-tagged	E.coli	GST	73 - 276 aa	$319 / 25ug
Human	RNF216-0612H	Recombinant Human RNF216 Protein (E2-F866), Tag Free	E.coli	No tag	E2-F866	Inquiry
Human	RNF216-0613H	Recombinant Human RNF216 Protein (E2-F866), His tagged	E.coli	His	E2-F866	Inquiry
Mouse	RNF216-14335M	Recombinant Mouse RNF216 Protein	Mammalian Cell	His		Inquiry
Mouse	RNF216-7677M	Recombinant Mouse RNF216 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	RNF216-7677M-B	Recombinant Mouse RNF216 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
Rnf216 Related Articles

Rnf216 involved in several pathways and played different roles in them. We selected most pathways Rnf216 participated on our site, such as Gastric cancer network 1, Immune System, Innate Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with Rnf216 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Gastric cancer network 1	ECT2;TOP2A;TPX2;SMOC2;LIN9;MYBL2;C21orf33;ESM1;S100P
Immune System	CSH1;TREX1;DEFB129;ASB13;UBR1;BTR22;PELI3;CFHL1;TRIM48
Innate Immune System	ABI1;LY86;NLRP4E;TLR6;MB21D1;NCKAP1;BAIAP2;RNF135;FCN2
Negative regulators of RIG-I/MDA5 signaling	TAX1BP1B;RNF216;TAX1BP1;NLRC5;RNF135;CYLD;HERC5;PCBP2
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways	TAX1BP1B;TANK;PCBP2;TAX1BP1;RNF216;RNF135;HERC5;NLRC5
TNF-alpha/NF-kB Signaling Pathway	MCC;PAPOLA;LRPPRC;RNF25;PEG3;KTN1;DCAF7;KPNA6;NR2C2
protein ubiquitylation	UBE2U;UBE2E3;UEVLD;RNF216;UBA5

Rnf216 has several biochemical functions, for example, ligase activity, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Rnf216 itself. We selected most functions Rnf216 had, and list some proteins which have the same functions with Rnf216. You can find most of the proteins on our site.

Function	Related Protein
ligase activity	MKRN3;PIAS1;CPS1;MARCH11;MYLIP;CNOT4;KCMF1;RNF187;TRIM17
metal ion binding	SMAD9;ZFYVE16;BTR18;BA1;KLF11B;ZDHHC18A;TNK2;COL27A1B;DRL
protein binding	S100A1;P2RX7;LMO2;PYURF;SULT1A3;PPP5C;EIF4E;MAP4K3;DMAP1

Rnf216 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Rnf216 here. Most of them are supplied by our site. Hope this information will be useful for your research of Rnf216.

dinB; RNF11

Zhang, TT; Prives, C; et al. Cyclin A-CDK phosphorylation regulates MDM2 protein interactions. JOURNAL OF BIOLOGICAL CHEMISTRY 276:29702-29710(2001).