RORA
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Official Full Name
RAR-related orphan receptor A
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Overview
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2014] -
Synonyms
RORA; RAR-related orphan receptor A; ROR1; ROR2; ROR3; RZRA; NR1F1; RZR-ALPHA; nuclear receptor ROR-alpha; ROR-alpha; nuclear receptor RZR-alpha; transcription factor RZR-alpha; retinoid-related orphan receptor alpha; nuclear receptor subfamily 1 group F member 1; thyroid hormone nuclear receptor alpha variant 4; retinoic acid receptor-related orphan receptor alpha;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- E.coli
- HEK293
- HEK293 Cells
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Sf9 Insect Cell
- Wheat Germ
- Yeast
- Flag
- GST
- His
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- Myc|DDK
- N/A
- N
- SUMO
- No tag
- Tag Free
- Involved Pathway
- Protein Function
- Interacting Protein
- RORA Related Research Area
RORA involved in several pathways and played different roles in them. We selected most pathways RORA participated on our site, such as Circadian rhythm, Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with RORA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Circadian rhythm | PRKAG1;NR1D1;CRY1;PRKAB1;SKP1;CUL1;CLOCK;RBX1;ARNTL |
| Inflammatory bowel disease (IBD) | SMAD2;Il4ra;HLA-DRB4;STAT6;HLA-DPA1;Il2;SMAD3;H2-AB1;HLA-DRB5 |
RORA has several biochemical functions, for example, DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RORA itself. We selected most functions RORA had, and list some proteins which have the same functions with RORA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | EVX2;ZBTB42;ELK4;HOXB8A;MSXE;DEDD2;ZIC2;NKRF;CCDC79 |
| RNA polymerase II regulatory region sequence-specific DNA binding | CREB3L4;EOMES;EAF2;ARID3A;PRKCBP1L;TBX5;SP3;IKZF5;ALX4 |
| RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding | STAT3;NR4A2;PPARA;NR1H4;ESRRA;NR4A2B;NR5A1B;RORCA;RORCB |
| beta-catenin binding | CARM1;LZIC;GSK3B;AXIN2;SLC9A3R2;BCL9L;DACT2;SMAD3;CDH24 |
| core promoter sequence-specific DNA binding | MYOCD;H2AFY;SIRT1;MLL1;PRMT5;MEOX1;TRP53;NR4A3;MTA1 |
| oxysterol binding | RORA;RORC;OSBP;OSBPL5;GPR183 |
| protein binding | FGF13;TTK;HSPH1;RBM3;OSTF1;F2;TBC1D15;PLEKHN1;STRADA |
| sequence-specific DNA binding | DLX5A;TBX1;NKX2-1;TRP53;E2F1;HLFA;NKX2-6;ATF4B2;FOXN1 |
| steroid hormone receptor activity | RXRB;RORB;RARG;PPARA;NR6A1B;VDRB;NR4A2B;ESRRB;NR4A2 |
| transcription coactivator binding | NR4A3;RORA;ZBTB49;PASD1;TERT |
| transcription corepressor binding | NR1D1;FAM89B;RORA;SIX3;HDGF |
| transcription factor activity, direct ligand regulated sequence-specific DNA binding | RORA;RORC |
| transcription factor activity, sequence-specific DNA binding | SALL3;NR5A1B;ATF7B;FOXG1B;PRDM1A;PRRX2;CNBP;PHF1;IKZF1 |
| transcription factor binding | CD34;SLC26A5;KCTD1;AGTR2;SIX2;UBE2I;ENPP2;MED6;RNF222 |
| zinc ion binding | INTS12;UBR2;WHSC1L1;S100A9;TRIM108;UBR3;PEX2;NR6A1;TRIM3B |
RORA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RORA here. Most of them are supplied by our site. Hope this information will be useful for your research of RORA.
GFAP; PSMC5; NR0B1; NCOA1; LMO3; Bhlhe41; Csnk1e; st2a1_human_gene
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