rora
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  • Official Full Name
  • RAR-related orphan receptor A
  • Background
  • The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2014]
  • Synonyms
  • RORA; RAR-related orphan receptor A; ROR1; ROR2; ROR3; RZRA; NR1F1; RZR-ALPHA; nuclear receptor ROR-alpha; ROR-alpha; nuclear receptor RZR-alpha; transcription factor RZR-alpha; retinoid-related orphan receptor alpha; nuclear receptor subfamily 1 group F member 1; thyroid hormone nuclear receptor alpha variant 4; retinoic acid receptor-related orphan receptor alpha;
Cat.#:RORA-3928HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human RORA Protein, GST-tagged
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Cat.#:RORA-3931HTag:MYC/DDK
Source (Host):HEK293 CellsSpecies:Human
Product nameRecombinant Human RORA Protein, MYC/DDK-tagged
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Cat.#:RORA-1083HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RORA protein, His & T7-tagged
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Cat.#:RORA-5489CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RORA
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Cat.#:RORA-1481HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ROR2 (Active), GST-tagged
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Cat.#:RORA-2247HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RORA 293 Cell Lysate
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Cat.#:RORA-2248HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RORA 293 Cell Lysate
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Cat.#:RORA-2249HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RORA 293 Cell Lysate
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Involved Pathway

RORA involved in several pathways and played different roles in them. We selected most pathways RORA participated on our site, such as Circadian rhythm, Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with RORA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Circadian rhythm
PRKAA2; PRKAA1; CLOCK; CSNK1E; PRKAB1; BHLHE40; PER1; CRY1; RBX1; SKP1
Inflammatory bowel disease (IBD)
SMAD2; RELA; IL6; RORA; MAF; IL22; TLR4; IL12RB1; TBX21; STAT3

Protein Function

RORA has several biochemical functions, for example, DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RORA itself. We selected most functions RORA had, and list some proteins which have the same functions with RORA. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein EMX3; TTF2; PRM2; FOXA2; ZNF654; ETV5; ZNF32; GTF2F2A; SETBP1; NKX2.4A
Function RNA polymerase II regulatory region sequence-specific DNA binding
Related Protein OSR2; LEF1; PHOX2A; ZNF561; JARID2; LMO2; TRP53; GATA6; PHF21A; FOXF2
Function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
Related Protein PGR; NR2F5; PPARG; NR2F6; NR4A2; PPARD; PPARAA; NR1I3; NR1D2; NR1I2
Function beta-catenin binding
Related Protein SOX17; ASH2L; PARK2; CTNNBIP1; DVL3; SHROOM2; MED12; CTNNA1; ESR1; SMAD3
Function core promoter sequence-specific DNA binding
Related Protein THRAP3; MEOX1; CHD2; SP1; MLL1; TOP1; ZFP932; ZFHX3; C1orf51; ESR1
Function oxysterol binding
Related Protein OSBPL5; RORA; OSBP; GPR183; RORC
Function protein binding
Related Protein PEX19; ZRANB1; FAM109A; MGRN1; GLIS2; CD300LH; SIPA1L2; STAMBP; TCEANC2; UBE2D4
Function sequence-specific DNA binding
Related Protein SIX4; BCL11AB; GLI2; HOXC11A; HOXA9A; TBX5; HOXA10B; LHX8A; RERE; FOXO3B
Function steroid hormone receptor activity
Related Protein NR1D4B; THRA; NR5A1A; PPARG; NR4A3; RORAB; NR2F1B; NR2E3; PPARD; NR5A2
Function transcription coactivator binding
Related Protein TERT; ZBTB49; RORA; PASD1; NR4A3
Function transcription corepressor binding
Related Protein SIX3; FAM89B; NR1D1; RORA; HDGF
Function transcription factor activity, direct ligand regulated sequence-specific DNA binding
Related Protein RORA; RORC
Function transcription factor activity, sequence-specific DNA binding
Related Protein TBX18; EGR4; TEAD3; ZNF484; DMRTC1B; RORC; RFX5; ZSCAN2; FOXD2; ZFP131
Function transcription factor binding
Related Protein HDAC11; GTF2A2; TFAP2A; FOXA2; NFYC; SRF; SUMO1; UBE2I; TCF3; PITX2
Function zinc ion binding
Related Protein PHF21A; RNF26; CXXC5; NEIL2; TP53; RORAA; C6AST3; PRKCA; LIMS1; ZFP37

Interacting Protein

RORA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RORA here. Most of them are supplied by our site. Hope this information will be useful for your research of RORA.
GFAP; PSMC5; NR0B1; NCOA1; LMO3; Bhlhe41; Csnk1e; st2a1_human_gene