RPA1
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Official Full Name
replication protein A1, 70kDa
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Overview
RPA70 (HSSB, REPA1, RF-A, RP-A, p70) is a component of a heterotrimeric complex, composed of 70, 32/30 and 14 kDa subunits, collectively known as RPA. RPA is a single stranded DNA binding protein, whose DNA binding activity is believed to reside entirely -
Synonyms
RPA1; replication protein A1, 70kDa; replication protein A1 (70kD); replication protein A 70 kDa DNA-binding subunit; HSSB; REPA1; RF A; RP A; RPA70; MSTP075; RP-A p70; RF-A protein 1; replication factor A protein 1; single-stranded DNA-binding protein; R;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E. coli
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Flag
- GST
- His
- His (Fc)
- Avi
- SUMO
- Myc
- DDK
- Myc|DDK
- N/A
- N
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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| Human | RPA1-2366H | Recombinant Human RPA1, GST-tagged | E.coli | GST | C-term-300aa | |
| Human | RPA1-31145TH | Recombinant Human RPA1, His-tagged | E.coli | His |
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| Human | RPA1-31147H | Recombinant Human RPA1 protein, GST-tagged | E.coli | GST | 317-616 aa | |
| Human | RPA1-31146H | Recombinant Human RPA1, MYC/DDK-tagged | HEK293 | Myc/DDK |
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| Human | RPA1-2243HCL | Recombinant Human RPA1 293 Cell Lysate | HEK293 | N/A |
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| Human | RPA1-2030H | Recombinant Human RPA1 Protein, His&GST-tagged | E.coli | N-His&GST | Asp18-Pro403 |
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| Human | RPA1-3849H | Recombinant Human RPA1 protein, His-tagged | E. coli | His | 317-616 aa |
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| Human | RPA1-685HFL | Recombinant Full Length Human RPA1 Protein, C-Flag-tagged | Mammalian cells | Flag |
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| Human | RPA1-1909H-B | Recombinant Human RPA1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Human | RPA1-1909H | Recombinant Human RPA1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Human | RPA1-3848H | Recombinant Human RPA1 protein, His-tagged | E. coli | His | 1-317 aa |
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| Human | RPA1-3439H | Recombinant Human RPA1 protein, His-SUMO-tagged | E.coli | His-SUMO | 2-616aa |
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| Mouse | Rpa1-5578M | Recombinant Mouse Rpa1 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
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| Rat | Rpa1-2029R | Recombinant Rat Rpa1 Protein, His-tagged | E.coli | N-His | Ser486-Ile680 |
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| Zebrafish | RPA1-10194Z | Recombinant Zebrafish RPA1 | Mammalian Cell | His |
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| Chicken | RPA1-1369C | Recombinant Chicken RPA1 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- RPA1 Related Articles
RPA1 involved in several pathways and played different roles in them. We selected most pathways RPA1 participated on our site, such as DNA replication, Nucleotide excision repair, Mismatch repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA replication | RFC5;PRIM2;GMNN;MCM4;PRIM1;POLD1;GINS4;POLE3;LIG1 |
| Nucleotide excision repair | COPS3;TFPT;CUL4B;ERCC5;RPA4;RPA1;CUL4A;COPS7B;ERCC6 |
| Mismatch repair | EXO1;SSBP1;RPA3;RPA4;RPA2;POLD4;MLH3;RFC3;MLH1 |
| Homologous recombination | RPA3;RAD54L;POLD4;NBN;XRCC2;MRE11A;RAD51C;RAD54B;RPA1 |
| Fanconi anemia pathway | POLN;RPA4;POLH;BLM;FANCA;RMI1;WDR48;C19orf40;FANCI |
RPA1 has several biochemical functions, for example, G-protein coupled receptor activity, photoreceptor activity, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RPA1 itself. We selected most functions RPA1 had, and list some proteins which have the same functions with RPA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled receptor activity | COR6;GPR45;TPRA1;GPR115;FZD1;DRD1A;GPRC5A;TAAR13B;GPR68 |
| photoreceptor activity | PARAPINOPSINB;OPN1LW2;RGS1;GRK7A;TMTOPSA;RRH;OPN4XB;RHOL;OPN3 |
| receptor activity | KLRB1F;CLEC4M;ATP6AP2;GRIA3B;NPC1;AMHR2;ICAM1;NOTCH4;PVRL1B |
RPA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPA1.
RPA2; RPA3; WRN
- Q&As
- Reviews
Q&As (6)
Ask a questionRPA1 protein is involved in important steps such as pairing, redox, and fusion in DNA recombination, and is necessary to effectively maintain genome integrity and stability.
RPA1 protein participates in DNA damage repair, growth and development in embryonic development, and has a role in maintaining the genome in embryos.
Since RPA1 protein plays an important role in DNA oxidative damage repair, it can be used as a marker of the degree of DNA oxidative damage to monitor and detect the risk of related diseases.
Although RPA1 protein is not a factor directly involved in DNA methylation modification, it may be involved in DNA methylation by participating in processes such as DNA damage repair, chromatin structure, and regulation of gene expression.
Studies have shown that RPA1 protein is involved in processes such as insulin secretion and regulation of β cell function in diabetes, and may become a new target for therapeutic strategies.
The RPA1 protein is involved in DNA damage repair and cell cycle in the immune system, and studies have found that it may be involved in processes such as immune response and pattern recognition.
Customer Reviews (3)
Write a reviewThe background of RPA1 in Western blot was very clean and showed good antibody specificity.
Beacuse reproducibility of RPA1 was very good and consistent results were obtained in each experiment, which gave me more confidence in the experimental results.
RPA1 have a wide range of applications and can be used in various biological experiments.
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