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RPH3AL

Official Full Name

rabphilin 3A-like (without C2 domains)
Overview

The protein encoded by this gene plays a direct regulatory role in calcium-ion-dependent exocytosis in both endocrine and exocrine cells and plays a key role in insulin secretion by pancreatic cells. This gene is likely a tumor suppressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Synonyms

RPH3AL; rabphilin 3A-like (without C2 domains); rab effector Noc2; Noc2; no C2 domains protein;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
His|SUMO
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	RPH3AL-2232HCL	Recombinant Human RPH3AL 293 Cell Lysate	HEK293	N/A		Inquiry
Human	RPH3AL-1157H	Recombinant Human RPH3AL Protein (1-315 aa), His-SUMO-tagged	E.coli	His/SUMO	1-315 aa	Inquiry
Mouse	RPH3AL-14401M	Recombinant Mouse RPH3AL Protein	Mammalian Cell	His		Inquiry
Mouse	RPH3AL-7718M	Recombinant Mouse RPH3AL Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	RPH3AL-7718M-B	Recombinant Mouse RPH3AL Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	RPH3AL-5106R	Recombinant Rat RPH3AL Protein	Mammalian Cell	His		Inquiry
Rat	RPH3AL-4765R-B	Recombinant Rat RPH3AL Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	RPH3AL-4765R	Recombinant Rat RPH3AL Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein
RPH3AL Related Articles

RPH3AL involved in several pathways and played different roles in them. We selected most pathways RPH3AL participated on our site, such as Deregulation of Rab and Rab Effector Genes in Bladder Cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPH3AL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Deregulation of Rab and Rab Effector Genes in Bladder Cancer	SYTL4;MLPH;TBC1D10A;SYTL2;RPH3AL;EXPH5;MYRIP;UNC13D;GCC2

RPH3AL has several biochemical functions, for example, LIM domain binding, Rab GTPase binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPH3AL itself. We selected most functions RPH3AL had, and list some proteins which have the same functions with RPH3AL. You can find most of the proteins on our site.

Function	Related Protein
LIM domain binding	LDB2B;LDB1;LDB2;LDB1A;TLN1;LDB2A;ACTN2;LDB1B;RPH3AL
Rab GTPase binding	RAB11FIP3;LLGL1;RAB3GAP2;PIFO;FER;GOLGA5;ODF2;MLPHB;NDRG1
calcium ion binding	CRACR2B;SYT4;EMR4;BRAF;THBS3;PRSS3;MMP13;MFGE8A;COMP
calcium-dependent phospholipid binding	ANXA11A;SYT1B;SYT11;SYT12;ANXA9;SYT9;SYT7;ANXA3;SYT5A
clathrin binding	SMAP1;PICALMB;SCLT1;HIP1;DOC2B;LRRK2;SYT13;SYT1A;CCDC167
cytoskeletal protein binding	NF2A;CAPN1;EZRA;FLNC;EPB41L3B;TPM1;ANXA2B;FARP2;DYNLL2
protein binding	TNS3;MAP3K9;DYNLL1;RINT1;ESR1;UBE2C;MT1X;ALDH7A1;CRMP1
syntaxin binding	TXLNA;HECTD3;STX8;CPLX4C;SYT17;SNAP23;SYT12;SCFD1;SYT1A

RPH3AL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPH3AL here. Most of them are supplied by our site. Hope this information will be useful for your research of RPH3AL.

MID2; TCEA3; mutY

Chen, JS; Kuo, YB; et al. Detection of autoantibodies against Rabphilin-3A-like protein as a potential biomarker in patient's sera of colorectal cancer. CLINICA CHIMICA ACTA 412:1417-1422(2011).