rps6ka3
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  • Official Full Name
  • ribosomal protein S6 kinase, 90kDa, polypeptide 3
  • Background
  • The RSK or 90-kDa ribosomal S6 kinase family of proteins isa group of highly conserved Ser/Thr kinases that regulatediverse cellular processes during the growth factor mediatedstimulation of cell proliferation, survival anddifferentiation (1). In mammals, four RSK genes havebeen identified (RSK1, RSK2, RSK3 and RSK4), and the RSKisoforms are composed of two distinct and functionalkinase domains that are activated in a sequentialmanner by a series of phosphorylation events. RSKs aredownstream effectors of the Ras-extracellular signal regulatedkinase (ERK)/mitogen-activated protein kinase(MAPK) signalling cascade.
  • Synonyms
  • RPS6KA3; ribosomal protein S6 kinase, 90kDa, polypeptide 3; CLS, Coffin Lowry syndrome , mental retardation, X linked 19 , MRX19, ribosomal protein S6 kinase, 90kD, polypeptide 3; ribosomal protein S6 kinase alpha-3; HU 3; RSK; RSK2; RSK-2; p90-RSK 3; MAPKAPK-1b; S6K-alpha-3; MAPKAP kinase 1b; ribosomal S6 kinase 2; MAPK-activated protein kinase 1b; insulin-stimulated protein kinase 1; MAP kinase-activated protein kinase 1b; CLS; HU-3; MRX19; ISPK-1; p90-RSK2; pp90RSK2; MAPKAPK1B; S6K-alpha3
Cat.#:RPS6KA3-153HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human RPS6KA3, GST-tagged
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Cat.#:RPS6KA3-154HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human RPS6KA3, GST-tagged
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Cat.#:RPS6KA3-155HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human RPS6KA3, GST-tagged
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Cat.#:RPS6KA3-30417THTag:
Source (Host):Species:Human
Product nameRecombinant Human RPS6KA3
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Cat.#:RPS6KA3-398HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human RPS6KA3
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Cat.#:RPS6KA3-425HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human RPS6KA3, GST-tagged, Active
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Cat.#:RPS6KA3-14495MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse RPS6KA3 Protein
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Cat.#:RPS6KA3-2161HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RPS6KA3 293 Cell Lysate
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Involved Pathway

RPS6KA3 involved in several pathways and played different roles in them. We selected most pathways RPS6KA3 participated on our site, such as MAPK signaling pathway, Oocyte meiosis, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPS6KA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
CDC42; IKBKB; PTPRR; MAPK8A; CACNB1; BRAF; TGFBR1B; GADD45BA; PPP3CB; Pdgfa&Pdgfb
Oocyte meiosis
PKMYT1; YWHAG1; CALM2B; CTH1; Adcy4; CPEB1B; CALM1A; PRKACBA; RPS6KA3B; PPP1CC
mTOR signaling pathway
AKT2L; PIK3R5; MAPK3; PTEN; RPS6KA3; AKT1; EIF4E1B; RPS6KB1; TNF; RPTOR
Long-term potentiation
PRKCA; PRKCB; PLCB3; PPP1CA; NRAS; PLCB4; GRIA1; GRIN2D; CAMK2A; CAMK2G
Neurotrophin signaling pathway
BDNF; NTRK2; MAPK9; CDC42; PIK3CB; SHC3; BCL2; SH2B2; MAPK13; ABL1
Progesterone-mediated oocyte maturation
PLK1; PIK3R1; IGF1R; CDC16; MAPK12; MAD2L2; PGR; ARAF; PIK3CD; CDK1
Insulin resistance
NR1H3; RPS6KAL; NFKBIAB; PIK3R3B; INSB; MAPK8; GSK3B; FOXO1A; SLC2A1A; PTENB

Protein Function

RPS6KA3 has several biochemical functions, for example, ATP binding, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPS6KA3 itself. We selected most functions RPS6KA3 had, and list some proteins which have the same functions with RPS6KA3. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein RECQL5; PFKM; IGF1RB; HSP90AA1.2; CSNK2A1; ATP4A; ERCC3; MAPK8B; ADCY3; PCXB
Function cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Related Protein SERPINB1A; XIAP; VIL1; DPEP1; GAS6; SERPINB9; ARRB1; C1QL4L; TFAP2B; BIRC7
Function magnesium ion binding
Related Protein TSSK2; NUDT5; TSSK6; PKMB; FIGNL1; PKLR; PPM1AA; HACL1; STK11; RNASEH1
Function protein binding
Related Protein SMNDC1; CX3CL1; EPHA2; DLA; F2; RAB6B; BDKRB2; COL4A3BP; ZNF652; CDKN2AIP
Function protein kinase activity
Related Protein EPHA4A; PRKDC; SYK; DCLK2; PRKACBB; INSRA; NEK1; NAT1; CAMK1DA; PKDCC
Function protein kinase binding
Related Protein LCK; WAS; TRAF6; CEP68; RAD9A; PTEN; CNTLN; PARN; CHRNA7; BORA
Function protein serine/threonine kinase activity
Related Protein STK32A; PASK; TRIO; GM7168; MAP3K14; AKT2L; SMG1; PIM2; MYO3B; AKT3
Function ribosomal protein S6 kinase activity
Related Protein RPS6KB1; RPS6KA3; RPS6KA3B; RPS6KA3A; RPS6KB1B; RPS6KA1; RPS6KB2; RPS6KA4; RPS6KA2; RPS6KA6

Interacting Protein

RPS6KA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPS6KA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPS6KA3.
MAPK1; saicar; MAPT; PKM; xmd8-92; biotin_acyl-p_probe; PDPK1; HSP90AB1; MCC; MAPK3; GSTK1; ATP5J; MASP1; SMS; CSNK2B; EIF3C; BARX1; Max

RPS6KA3 Related Articles

Mierzejewska, K; Heo, J; et al. Genome-wide analysis of murine bone marrow-derived very small embryonic-like stem cells reveals that mitogenic growth factor signaling pathways play a crucial role in the quiescence and ageing of these cells. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 32:281-290(2013).