rps6kb1
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  • Official Full Name
  • ribosomal protein S6 kinase, 70kDa, polypeptide 1
  • Background
  • p70S6K is responsible for the phosphorylation of 40Sribosomal protein S6, and is ubiquitously expressed inhuman adult tissues (1). p70S6K is activated by serumstimulation and this activation is inhibited by wortmanninand rapamycin. p70S6k activity changes during the cellcycle, and increases 20-fold in G1 cells released from G0(2). p70S6K activation requires sequential phosphorylationat proline-directed residues in the putative autoinhibitorypseudosubstrate domain, as well as threonine 389, a sitephosphorylated by phosphoinositide-dependent kinase 1(PDK-1).
  • Synonyms
  • RPS6KB1; ribosomal protein S6 kinase, 70kDa, polypeptide 1; ribosomal protein S6 kinase, 70kD, polypeptide 1 , STK14A; ribosomal protein S6 kinase beta-1; p70(S6K) alpha; PS6K; S6K1; P70S6K1; p70 S6KA; S6K-beta-1; p70 S6K-alpha; p70 S6 kinase, alpha 1; p70 S6 kinase, alpha 2; ribosomal protein S6 kinase I; serine/threonine kinase 14 alpha; serine/threonine-protein kinase 14A; 70 kDa ribosomal protein S6 kinase 1; S6K; STK14A; p70-S6K; p70-alpha; p70(S6K)-alpha
Cat.#:RPS6KB1-5478HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1, GST-tagged
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Cat.#:RPS6KB1-376HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human RPS6KB1, His-tagged, Active
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Cat.#:RPS6KB1-560HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human RPS6KB1, GST-tagged
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Cat.#:RPS6KB1-13HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RPS6KB1 Protein, His-tagged
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Cat.#:RPS6KB1-195HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human RPS6KB1, GST-tagged
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Cat.#:RPS6KB1-23HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human RPS6KB1 protein, His-tagged, Unactive
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Cat.#:RPS6KB1-29261THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RPS6KB1, His-tagged
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Cat.#:RPS6KB1-31345THTag:His
Source (Host):Species:Human
Product nameRecombinant Human RPS6KB1, His-tagged
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Cat.#:RPS6KB1-556HTag:His
Source (Host):Sf 9 insect cellsSpecies:Human
Product nameRecombinant Human RPS6KB1, His-tagged
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Cat.#:RPS6KB1-8524HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human RPS6KB1, GST tagged
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Cat.#:Rps6kb1-143RTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Rat
Product nameRecombinant Rat Rps6kb1(T412E), His-tagged
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Cat.#:RPS6KB1-5173RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat RPS6KB1 Protein
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Cat.#:RPS6KB1-2422CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RPS6KB1
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Cat.#:RPS6KB1-001HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human RPS6KB1 cell lysate
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Involved Pathway

RPS6KB1 involved in several pathways and played different roles in them. We selected most pathways RPS6KB1 participated on our site, such as ErbB signaling pathway, HIF- signaling pathway, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPS6KB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
PIK3R3B; AKT2L; PAK7; MAPK3; PRKCBA; CBLB; MTOR; STAT5B; STAT5A; CAMK2B
HIF- signaling pathway
PLCG1; EIF4E2; NFKB1; HK2; PRKCA; Trf; IFNG; NOS2; TFRC; PDHA2
mTOR signaling pathway
VEGFAB; RPS6KA1; STRADA; VEGFAA; RPS6KA3; AKT3A; RPTOR; PDPK1B; HIF1AB; EIF4E2RS1
PIK-Akt signaling pathway
PRL; IFNB1; MET; ITGA6; FGF1; FGF22; FOXO3; TCL1B4; PGF; MLST8
AMPK signaling pathway
TSC2; ADRa1A; CAMKK1; IRS4; PPP2R5D; CD36; CREB5; PIK3R5; FASN; PPP2CB
TGF-beta signaling pathway
BMP8A; ROCK1; ID3; ACVR1BA; AMHR2; GDF5; FSTA; BMPR2A; ID2B; TGFB3
Fc gamma R-mediated phagocytosis
PIK3CG; PRKCB; PLD1; PPAP2C; PTPRC; cgr2b; NCF1; GAB2; PLA2G4F; MARCKSL1
Insulin signaling pathway
PRKACAA; EIF4E1C; PRKACAB; CALM; PTPRFB; G6PC3; PRKAR2AB; INS1; MKNK1; AKT1
Insulin resistance
PCK1; G6PC; G6PC3; PIK3CB; PIK3R1; CREB3L3; PRKAG2; PDPK1B; CREB3L2; FOXO1
Proteoglycans in cancer
ROCK1; VTN; WNT8A; PAK1; NUDT16L1; PPP1R12B; HIF1A; PLAUR; MMP9; TFAP4
Acute myeloid leukemia
GRB2; CCNA1; CCND1; KRAS; KIT; PPARD; ARAF; RARA; RELA; TCF7L2
Choline metabolism in cancer
DGKD; PIK3CA; HIF1A; PRKCB; PLD1; DGKA; PIP5K1B; PPAP2B; PIP5K1C; RAC1

Protein Function

RPS6KB1 has several biochemical functions, for example, ATP binding, peptide binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPS6KB1 itself. We selected most functions RPS6KB1 had, and list some proteins which have the same functions with RPS6KB1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein GTF2F2; CDK5; ATP2A2A; GALK2; HSPA6; TTLL1; SYN3; ROCK2A; PRKCBB; ATP6V1A
Function peptide binding
Related Protein NPFFR1; ANPEP; QRFPR; NPFFR1L1; THOP1; NPFFR2.1; ANPEPB; ERAP2; HCRTR1; NPFFR1L3
Function protein binding
Related Protein CAPRIN2; SCEL; COLQ; CCDC67; ALKBH3; CEP164; VSTM2L; PAN2; GDF7; IRF4
Function protein kinase activity
Related Protein RPS6KB2; CAMK1GB; JAK2; NEK10; NEK4; PKN3; CHEK1; PRKCBA; DCKL1B; SCYL1
Function protein phosphatase 2A binding
Related Protein ENSA; ENSAA; IGBP1; TRP53; TP53; MAPT; GRIN3A; AKT1; SPHK1; STRN
Function protein serine/threonine/tyrosine kinase activity
Related Protein PRKACA; CLK3; DYRK1AA; AKT1; DYRK2; TTK; RPS6KA1; DYRK1B; PRKCG; CLK4
Function ribosomal protein S6 kinase activity
Related Protein RPS6KA3; RPS6KB1B; RPS6KA4; RPS6KB1; RPS6KA1; RPS6KA2; RPS6KA3B; RPS6KB2; ALPK2; RPS6KA6

Interacting Protein

RPS6KB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPS6KB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPS6KB1.
AKT1; EIF3B; COASY; PPP2R2B; MAPT; MAPT; PDK1; GLI1; HSP90AB1; STK11