rptor
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  • Official Full Name
  • regulatory associated protein of MTOR, complex 1
  • Background
  • This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • KOG1; Mip1; KIAA1303; regulatory-associated protein of mTOR; raptor; p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats; RPTOR; regulatory associated protein of MTOR, complex 1
Cat.#:RPTOR-30506THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human RPTOR
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Cat.#:RPTOR-1543HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RPTOR cell lysate
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Involved Pathway

RPTOR involved in several pathways and played different roles in them. We selected most pathways RPTOR participated on our site, such as mTOR signaling pathway, PIK-Akt signaling pathway, AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPTOR were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
mTOR signaling pathway
AKT3A; PIK3R2; MAPK3; RPS6KB1B; EIF4BB; TSC2; PDPK1B; RB1CC1; RHEB; TSC1B
PIK-Akt signaling pathway
IL2RG; HSP90AA1; THBS2; Il6ra; G6PC2; THBS4; PDGFA; IFNA6; LAMB2; PPP2CA
AMPK signaling pathway
FBP2; FASN; CCND1; HMGCR; IGF1R; PPP2R1B; G6PC; RAB10; PDPK1; PRKAG3
Insulin signaling pathway
PRKACBA; PKLR; PRKAB1B; HKDC1; PHKG1A; G6PC; G6PC2; FLOT1A; PRKAB1A; ACACA
MicroRNAs in cancer
PRKCA; MDM2; RECK; NOTCH2; EFNA3; TIMP3; TNR; GRB2; BCL2L2; ZEB2

Protein Function

RPTOR has several biochemical functions, for example, 14-3-3 protein binding, RNA polymerase III type 1 promoter DNA binding, RNA polymerase III type 2 promoter DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPTOR itself. We selected most functions RPTOR had, and list some proteins which have the same functions with RPTOR. You can find most of the proteins on our site.
Function
Related Protein
Function 14-3-3 protein binding
Related Protein AKT1; KCNH1; KIF13B; ZFP36; HDAC7A; RPTOR; PPP1R12A; AANAT; ARRB2; YWHAQ
Function RNA polymerase III type 1 promoter DNA binding
Related Protein MAF1; RPTOR; MTOR
Function RNA polymerase III type 2 promoter DNA binding
Related Protein MAF1; RPTOR; MTOR
Function RNA polymerase III type 3 promoter DNA binding
Related Protein RPTOR; MTOR; MAF1
Function TFIIIC-class transcription factor binding
Related Protein RPTOR; MTOR
Function protein binding
Related Protein IMMT; MC4R; H3F3A; PIM2; ANKZF1; ANXA6; CDX4; HSD17B12; KRT5; GNB2L1
Function protein complex binding
Related Protein KIF11; PDX1; NFKBIA; RAP1B; ADM2; TXN2; ADRB2; VPS28; LRP1; ITGB1BP1
Function protein kinase binding
Related Protein CD36; SPDYB; PRKAB1; MAP3K1; CRY1; TUBB3; CCNYL1; PPME1; CDK5RAP3; DNAJC3

Interacting Protein

RPTOR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPTOR here. Most of them are supplied by our site. Hope this information will be useful for your research of RPTOR.
MTOR

RPTOR Related Articles

Szymanska, P; Martin, KR; et al. Computational Analysis of an Autophagy/Translation Switch Based on Mutual Inhibition of MTORC1 and ULK1. PLOS ONE 10:-(2015).
Rajkumar, AP; Christensen, JH; et al. Analysis of t(9;17)(q33.2; q25.3) chromosomal breakpoint regions and genetic association reveals novel candidate genes for bipolar disorder. BIPOLAR DISORDERS 17:205-211(2015).