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RRAD

Official Full Name

Ras-related associated with diabetes
Overview

May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.
Synonyms

RRAD; Ras-related associated with diabetes; RAD; RAD1; REM3; GTP-binding protein RAD; ras associated with diabetes; RAS (RAD and GEM) like GTP binding 3;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell
Mammalian cells
Wheat Germ

Tag

Flag
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	RRAD-30772TH	Recombinant Human RRAD	Wheat Germ	N/A	110 amino acids	Inquiry
Human	RRAD-1679H	Recombinant Human RRAD Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	RRAD-1676HFL	Recombinant Full Length Human RRAD Protein, C-Flag-tagged	Mammalian cells	Flag		Inquiry
Human	RRAD-6686H	Recombinant Human RRAD Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	RRAD-1918H	Recombinant Human RRAD Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Human	RRAD-2818H	Recombinant Human RRAD protein, His-tagged	E.coli	His	39 - 141 aa	$319 / 25ug
Human	RRAD-1918H-B	Recombinant Human RRAD Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Rrad-5618M	Recombinant Mouse Rrad Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Zebrafish	RRAD-10186Z	Recombinant Zebrafish RRAD	Mammalian Cell	His		Inquiry
Chicken	RRAD-4985C	Recombinant Chicken RRAD	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
RRAD Related Articles

RRAD involved in several pathways and played different roles in them. We selected most pathways RRAD participated on our site, such as Insulin Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with RRAD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Insulin Signaling	MAP4K5;MAP3K9;MINK1;INPP4AA;MAP3K10;FLOT1;MAP3K2;STXBP1A;STXBP2

RRAD has several biochemical functions, for example, GTP binding, GTPase activity, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RRAD itself. We selected most functions RRAD had, and list some proteins which have the same functions with RRAD. You can find most of the proteins on our site.

Function	Related Protein
GTP binding	GTPBP2;RALBB;RAB42B;ASCL1B;NRAS;ARL15A;RHOT1A;ARL5B;RSG1
GTPase activity	RAB33B;GNA15.1;RAB4B;GNGT2;REM2;EEFSEC;GNA13A;GNA13B;RRAGA
calmodulin binding	TRPV4;PPP3CB;MYH1B;IQGAP3;MAP6;MYO3A;AEBP1;MKNK2A;NDUFAF4
protein binding	TACSTD2;RBM8A;RUVBL1;UBR4;SMURF1;GNAQ;RFX3;LCA5;ALDOB

RRAD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RRAD here. Most of them are supplied by our site. Hope this information will be useful for your research of RRAD.

CCNDBP1; MMP14; CCDC141

Zhang, J; Chang, L; et al. Rad GTPase inhibits cardiac fibrosis through connective tissue growth factor. CARDIOVASCULAR RESEARCH 91:90-98(2011).

Zhu, JH; Tseng, YH; et al. Interaction of the Ras-related protein associated with diabetes Rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 96:14911-14918(1999).

Garvey, WT; Maianu, L; et al. Muscle Rad expression and human metabolism - Potential role of the novel ras-related GTPase in energy expenditure and body composition. DIABETES 46:444-450(1997).