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RRM2

  • Official Full Name

    ribonucleotide reductase M2

  • Overview

    This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X.
  • Synonyms

    RRM2; ribonucleotide reductase M2; ribonucleotide reductase M2 polypeptide; ribonucleoside-diphosphate reductase subunit M2; ribonucleotide reductase small chain; ribonucleotide reductase small subunit; R2; RR2; RR2M;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RRM2-2445H Recombinant Human RRM2, GST-tagged E.coli GST 1-389aa
Human RRM2-705H Recombinant Human Ribonucleotide Reductase M2, His-tagged E.coli His
Human RRM2-30111TH Recombinant Human RRM2, T7 -tagged E.coli T7
Human RRM2-29474TH Recombinant Human RRM2, His-tagged E.coli His 389 amino acids
Human RRM2-820H Recombinant Human Ribonucleotide Reductase M2, T7-tagged E.coli T7
Human RRM2-1545HCL Recombinant Human RRM2 cell lysate N/A
Human RRM2-137HFL Active Recombinant Full Length Human RRM2 Protein, C-Flag-tagged Mammalian cells Flag
Human RRM2-1960H Recombinant Human RRM2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human RRM2-3451H Recombinant Human RRM2 protein, His-SUMO-tagged E.coli His-SUMO 1-389a
Human RRM2-69H Recombinant Human RRM2 Protein E.coli
Human RRM2-6206H Recombinant Human RRM2 Protein (Met1-Phe389), C-His tagged Mammalian cells C-His Met1-Phe389
Human RRM2-1922H Recombinant Human RRM2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human RRM2-1922H-B Recombinant Human RRM2 Protein Pre-coupled Magnetic Beads HEK293
Mouse RRM2-14525M Recombinant Mouse RRM2 Protein Mammalian Cell His
Mouse RRM2-7814M Recombinant Mouse RRM2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Rrm2-5627M Recombinant Mouse Rrm2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse RRM2-7814M-B Recombinant Mouse RRM2 Protein Pre-coupled Magnetic Beads HEK293
Rat RRM2-5181R Recombinant Rat RRM2 Protein Mammalian Cell His
Rat RRM2-4840R-B Recombinant Rat RRM2 Protein Pre-coupled Magnetic Beads HEK293
Rat RRM2-4840R Recombinant Rat RRM2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey RRM2-889C Recombinant Cynomolgus RRM2 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey RRM2-632C-B Recombinant Cynomolgus Monkey RRM2 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey RRM2-632C Recombinant Cynomolgus Monkey RRM2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish RRM2-9018Z Recombinant Zebrafish RRM2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • RRM2 Related Articles

RRM2 involved in several pathways and played different roles in them. We selected most pathways RRM2 participated on our site, such as Purine metabolism, Pyrimidine metabolism, Glutathione metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with RRM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Purine metabolismAK7B;PRPS2;GMPS;POLD1;ADPRM;AK9;APRT;PNPT1;NME4
Pyrimidine metabolismPOLR3E;DUT;POLR2C;POLR2F;DHODH;UPB1;POLR2J2;NT5M;TXNRD1
Glutathione metabolismGSTM5;GPX1A;GSTA2;GGT6;SRM;GGT5;GSTA;GSTA5;RRM2B
Metabolic pathwaysNADSYN1;ATP6V1E1;FDFT1;PET112L;IDI1;ATP6V1E2;ALDH3A1;B4GALT1;B4GALNT1
p signaling pathwayGTSE1;GADD45B;CCND2A;PMAIP1;SESN1;CASP8;GADD45AA;CCND1;SERPINB5

RRM2 has several biochemical functions, for example, metal ion binding, protein binding, ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Some of the functions are cooperated with other proteins, some of the functions could acted by RRM2 itself. We selected most functions RRM2 had, and list some proteins which have the same functions with RRM2. You can find most of the proteins on our site.

Function Related Protein
metal ion bindingZBTB16;RPP21;MFI2;HAGH;CYP2AA4;THAP2;ADPRHL2;PPTC7A;NEK1
protein bindingZBED1;FAM32A;WDR18;BCL3;FOXO3B;HIST1H4B;KCP;SETX;ORC6L
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptorRRM1;RRM2;RRM2B

RRM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RRM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RRM2.

CCNF; RRM1; FZR1; CDK1; q81kf8_bacan; TSG101

Osman, AM; van Loveren, H; et al. The immunosuppressant tributyltin oxide blocks the mTOR pathway, like rapamycin, albeit by a different mechanism. JOURNAL OF APPLIED TOXICOLOGY 34:1361-1367(2014).
Shodai, A; Ido, A; et al. Conserved Acidic Amino Acid Residues in a Second RNA Recognition Motif Regulate Assembly and Function of TDP-43. PLOS ONE 7:-(2012).
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