rrm2
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  • Official Full Name
  • ribonucleotide reductase M2
  • Background
  • This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X.
  • Synonyms
  • RRM2; ribonucleotide reductase M2; ribonucleotide reductase M2 polypeptide; ribonucleoside-diphosphate reductase subunit M2; ribonucleotide reductase small chain; ribonucleotide reductase small subunit; R2; RR2; RR2M
Cat.#:RRM2-1960HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human RRM2 Protein, MYC/DDK-tagged
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Cat.#:RRM2-2445HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RRM2, GST-tagged
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Cat.#:RRM2-29474THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RRM2, His-tagged
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Cat.#:RRM2-30111THTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RRM2, T7 -tagged
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Cat.#:RRM2-705HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ribonucleotide Reductase M2, His-tagged
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Cat.#:RRM2-820HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ribonucleotide Reductase M2, T7-tagged
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Cat.#:RRM2-14525MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse RRM2 Protein
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Cat.#:RRM2-5181RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat RRM2 Protein
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Cat.#:RRM2-889CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus RRM2 Protein, His-tagged
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Cat.#:RRM2-9018ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RRM2
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Cat.#:RRM2-1545HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RRM2 cell lysate
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Involved Pathway

RRM2 involved in several pathways and played different roles in them. We selected most pathways RRM2 participated on our site, such as Purine metabolism, Pyrimidine metabolism, Glutathione metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with RRM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Purine metabolism
NT5C; NUDT5; ENTPD4; PDE6B; POLR2E; CANT1; ENTPD3; GUCY2E; NT5C1AA; PDE4A
Pyrimidine metabolism
NME2; UCK2A; DPYDB; POLE2; POLR2D; PNPT1; udp; PNP6; TXNRD2; CAD
Glutathione metabolism
G6PD; GGT6; LAP3; MGST3; GPX1A; GSTA2; GSTO1; ODC1; GSTP2; GSTAL
Metabolic pathways
PNAT10; DNMT1; HIBADHB; CYP19A1; ASAH2; CYP26A1; ENO3; GNPDA2; LPCAT4; INPP5A
p signaling pathway
GADD45B; TSC2; CD82B; RPRMA; CCNG1; PIDD1; SERPINE1; SIAH1A; RCHY1; TP73

Protein Function

RRM2 has several biochemical functions, for example, metal ion binding, protein binding, ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Some of the functions are cooperated with other proteins, some of the functions could acted by RRM2 itself. We selected most functions RRM2 had, and list some proteins which have the same functions with RRM2. You can find most of the proteins on our site.
Function
Related Protein
Function metal ion binding
Related Protein TRIM35-21; ZBTB46; KDM5D; ZFP41; ARAP3; PPP3CB; FTR54; ARHGAP29B; ZNF234; DDX11
Function protein binding
Related Protein PLK2; COA3; GPBP1; PPP1R16B; FKBP1A; KLF3; LMX1B; SP1; RAB3B; FCER1G
Function ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
Related Protein RRM1; RRM2B; RRM2

Interacting Protein

RRM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RRM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RRM2.
CCNF; RRM1; FZR1; CDK1; q81kf8_bacan; TSG101

RRM2 Related Articles

Osman, AM; van Loveren, H; et al. The immunosuppressant tributyltin oxide blocks the mTOR pathway, like rapamycin, albeit by a different mechanism. JOURNAL OF APPLIED TOXICOLOGY 34:1361-1367(2014).
Shodai, A; Ido, A; et al. Conserved Acidic Amino Acid Residues in a Second RNA Recognition Motif Regulate Assembly and Function of TDP-43. PLOS ONE 7:-(2012).