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RRM2B

  • Official Full Name

    ribonucleotide reductase M2 B (TP53 inducible)

  • Overview

    This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]
  • Synonyms

    RRM2B; ribonucleotide reductase M2 B (TP53 inducible); P53R2; MTDPS8A; MTDPS8B; ribonucleoside-diphosphate reductase subunit M2 B; TP53-inducible ribonucleotide reductase M2 B; p53-inducible ribonucleotide reductase small subunit 2 homolog; p53-inducible ribonucleotide reductase small subunit 2-like protein; p53-inducible ribonucleotide reductase small subunit 2 short form beta;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RRM2B-2550H Recombinant Human RRM2B, His tagged E.coli His
Human RRM2B-2446H Recombinant Human RRM2B, GST-tagged E.coli GST 1-350aa
Human RRM2B-1963H Recombinant Human RRM2B Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human RRM2B-2847H Recombinant Human RRM2B protein(Met1-Phe351), His-tagged E. coli N-His Met1-Phe351
Human RRM2B-4558H Recombinant Human RRM2B protein, GST-tagged E.coli GST 1-351aa
Mouse RRM2B-14526M Recombinant Mouse RRM2B Protein Mammalian Cell His
Mouse RRM2B-7815M-B Recombinant Mouse RRM2B Protein Pre-coupled Magnetic Beads HEK293
Mouse RRM2B-7815M Recombinant Mouse RRM2B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Rrm2b-5628M Recombinant Mouse Rrm2b Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish RRM2B-1653Z Recombinant Zebrafish RRM2B Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • RRM2B Related Research Area

RRM2B involved in several pathways and played different roles in them. We selected most pathways RRM2B participated on our site, such as Purine metabolism, Pyrimidine metabolism, Glutathione metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with RRM2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Purine metabolismPKM;PDE2A;POLR1D;GMPR;NPR2;PRPS2;NME2;GUK1A;FHIT
Pyrimidine metabolismNME1-NME2;NT5C3A;POLR2F;POLR3A;UCK1;NT5C3B;POLA2;POLR2J;NME5
Glutathione metabolismGGCT;GPX7;SRM;GGT1;GGT5;GPX8;GSTM6;PGD;RRM2
Metabolic pathwaysHPSE;ABP1;B3GNTL2;B3GAT3;IPPK;MBOAT2B;NT5C1AA;HEXA;HGSNAT
p signaling pathwayCDK1;SERPINB5;CCND2;TRP53;STEAP3;CCNE1;RCHY1;BAXA;EI24

RRM2B has several biochemical functions, for example, metal ion binding, protein binding, ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Some of the functions are cooperated with other proteins, some of the functions could acted by RRM2B itself. We selected most functions RRM2B had, and list some proteins which have the same functions with RRM2B. You can find most of the proteins on our site.

Function Related Protein
metal ion bindingZNF599;ZNF592;ZFP579;ZFP27;CYP1A;SNAI1A;ESR2B;HBBE1.1;OMA1
protein bindingCD300A;UBE2D1;TOP3B;AKIP1;ELMO1;TNNI3;SYT4;SNX9;UBE2E1
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptorRRM2B;RRM2;RRM1

RRM2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RRM2B here. Most of them are supplied by our site. Hope this information will be useful for your research of RRM2B.

ORC4

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