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RTKN

  • Official Full Name

    rhotekin

  • Overview

    This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.
  • Synonyms

    RTKN; rhotekin; B5;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RTKN-27494TH Recombinant Human RTKN E.coli N/A
Human RTKN-1147H Recombinant Human Rhotekin, GST-tagged E.coli GST
Human RTKN-8057H Recombinant Human RTKN protein, His & GST-tagged E.coli His/GST Gln309~Phe416 (Accession # Q9BST9)
Human RTKN-27495TH Recombinant Human RTKN, His-tagged E.coli His
Human RTKN-2460H Recombinant Human RTKN, His-tagged E.coli His C-term-350aa
Human RTKN-2124HCL Recombinant Human RTKN 293 Cell Lysate HEK293 N/A
Human RTKN-6216H Recombinant Human RTKN Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse RTKN-14564M Recombinant Mouse RTKN Protein Mammalian Cell His
Mouse Rtkn-5641M Recombinant Mouse Rtkn Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Rtkn-2035M Recombinant Mouse Rtkn Protein, His&GST-tagged E.coli N-His&GST Gln309-Phe416
Mouse RTKN-7839M Recombinant Mouse RTKN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse RTKN-7839M-B Recombinant Mouse RTKN Protein Pre-coupled Magnetic Beads HEK293
Rat Rtkn-8058R Recombinant Rat Rtkn protein, His & T7-tagged E.coli His/T7 Gln296~Val548 (Accession # Q6V7V2)
Rat RTKN-5192R Recombinant Rat RTKN Protein Mammalian Cell His
Rat RTKN-4851R Recombinant Rat RTKN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat RTKN-4851R-B Recombinant Rat RTKN Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque RTKN-4050R Recombinant Rhesus monkey RTKN Protein, His-tagged Mammalian Cell His
Rhesus Macaque RTKN-3867R-B Recombinant Rhesus Macaque RTKN Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque RTKN-3867R Recombinant Rhesus Macaque RTKN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • RTKN Related Articles

RTKN involved in several pathways and played different roles in them. We selected most pathways RTKN participated on our site, such as Alpha6-Beta4 Integrin Signaling Pathway, G13 Signaling Pathway, RHO GTPase Effectors, which may be useful for your reference. Also, other proteins which involved in the same pathway with RTKN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Alpha6-Beta4 Integrin Signaling PathwayEGFR;COL17A1;DST;MST1R;EIF4E;EIF4EBP1;NTN1A;RTKN;SMAD3B
G13 Signaling PathwayCIT;RHPN2;MYL1;RTKN;DIAPH1;CFL2;ARHGEF1A;GNA13;TNK2
RHO GTPase EffectorsRCC2;SPC24;ROPN1;NOXA1;CIT;KTN1;NUF2;RHOAE;KDM4C
RHO GTPases Activate Rhotekin and RhophilinsRHOC;LIN7B;RTKN;ROPN1;TAX1BP3;RHPN2;RHPN1
Signal TransductionSCT;ADM2A;STRA6;ARHGEF17;KEL;LINGO1B;ADH8A;RYK;PRKCHB
Signaling by Rho GTPasesARHGAP25;ARHGAP12B;NCKIPSD;FGD4;NOXO1A;DCLRE1B;GMIP;RHOV;ARHGAP29B

RTKN has several biochemical functions, for example, GTP binding, GTP-Rho binding, GTPase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RTKN itself. We selected most functions RTKN had, and list some proteins which have the same functions with RTKN. You can find most of the proteins on our site.

Function Related Protein
GTP bindingARF6;MFN1B;RND3B;ARL4AB;RAB35;GNAS;GSPT2;RSG1;DNM3A
GTP-Rho bindingTNFAIP1;EXOC1;PKN1;STXBP6L;ROCK2A;CDC42EP4A;WHAMM;CDC42EP1B;KCTD13
GTPase inhibitor activityCDC42SE1;RHOH;SLIT2;GPS1;PDE6D;TNK2;CPEB2;IPO5;UBE4A
protein bindingSPATA24;IL28RA;STOML1;CTH;EPHA3;BMPR1AA;BTG1;PLK2;SKAP1

RTKN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RTKN here. Most of them are supplied by our site. Hope this information will be useful for your research of RTKN.

RHOA; Rhoa; SORBS3; SORBS3; sseJ; gtp; Rhoa; RAC1; q8jhe2_xenla; YWHAB

Sun, HR; Breslin, JW; et al. Rho and ROCK signaling in VEGF-induced microvascular endothelial hyperpermeability. MICROCIRCULATION 13:237-247(2006).
Jung, JW; Jung, SH; et al. High-throughput analysis of GST-fusion protein expression and activity-dependent protein interactions on GST-fusion protein arrays with a spectral surface plasmon resonance biosensor. PROTEOMICS 6:1110-1120(2006).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Is RTKN a potential therapeutic target in cancer treatment? 02/05/2019

Some studies propose RTKN as a potential therapeutic target for cancer, as inhibiting its activity may impede tumor progression.

How does RTKN contribute to cellular signaling pathways? 11/13/2018

RTKN is known to modulate signaling pathways, including those associated with cell survival, proliferation, and differentiation.

How is RTKN linked to neurodegenerative diseases? 08/26/2017

Some studies suggest that RTKN may be associated with neurodegenerative disorders, possibly influencing neuronal function.

Are there any known genetic mutations in the RTKN gene associated with diseases? 02/10/2017

Genetic variations in the RTKN gene have been investigated for potential links to certain diseases, but more research is needed to establish clear associations.

Can RTKN be targeted for drug development? 02/29/2016

The potential for developing drugs targeting RTKN is being explored, with a focus on its role in diseases such as cancer.

Customer Reviews (3)

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Reviews
07/21/2022

    They can offer specialized formulations, concentrations, or modifications of RTKN protein to suit unique experimental requirements.

    03/23/2022

      Collaborative discussions with the manufacturer can also help optimize experimental protocols and provide insights into the best practices in working with RTKN.

      12/27/2021

        The manufacturer can further support researchers by providing customized solutions tailored to their specific needs.

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