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RUNX2

  • Official Full Name

    runt-related transcription factor 2

  • Overview

    This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt;DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as;a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA;both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been;associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different;protein isoforms result from the use of alternate promoters as well as alternate splicing.
  • Synonyms

    RUNX2; runt-related transcription factor 2; CBFA1, CCD, CCD1; AML3; PEBP2A1; PEBP2aA1; CBF-alpha-1; PEA2-alpha A; PEBP2-alpha A; oncogene AML-3; acute myeloid leukemia 3 protein; SL3-3 enhancer factor 1 alpha A subunit; osteoblast-specific transcription f;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Chicken
  • Human
  • Mouse
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • His
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RUNX2-28321TH Recombinant Human RUNX2 Wheat Germ N/A 140 amino acids
Human RUNX2-30473TH Recombinant Human RUNX2 Wheat Germ N/A 100 amino acids
Human RUNX2-48H Recombinant Human RUNX2 protein, His-tagged E.coli His
Human RUNX2-2108HCL Recombinant Human RUNX2 293 Cell Lysate HEK293 N/A
Human RUNX2-2107HCL Recombinant Human RUNX2 293 Cell Lysate HEK293 N/A
Human RUNX2-6645H Recombinant Human RUNX2 Protein (Val219-Val404), N-His tagged E.coli N-His Val219-Val404
Human RUNX2-1163HFL Recombinant Full Length Human RUNX2 Protein, C-His-tagged E.coli His
Human RUNX2-6644H Recombinant Human RUNX2 Protein E.coli Tag Free
Mouse Runx2-5723M Recombinant Mouse Runx2 protein, His-tagged E.coli His Ser125~Ala352 (Accession # Q08775)
Chicken RUNX2-5704C Recombinant Chicken RUNX2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • RUNX2 Related Articles
  • RUNX2 Related Signal Pathway

RUNX2 involved in several pathways and played different roles in them. We selected most pathways RUNX2 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with RUNX2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Transcriptional misregulation in cancerATF1;GZMB;SPI1;PER2;SUPT3H;BCL2A1;RUNX1;CLSTN2;ATM

RUNX2 has several biochemical functions, for example, ATP binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RUNX2 itself. We selected most functions RUNX2 had, and list some proteins which have the same functions with RUNX2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingIRAK3;CSK;CLK2B;UBE2E1;PAPSS1;MKNK1;ASCC3;STK24;ATM
RNA polymerase II core promoter proximal region sequence-specific DNA bindingNFATC4;PAXBP1;MYB;HOXA5;MZF1;NEUROD6;RBPJB;RFX5;NR1D1
RNA polymerase II core promoter sequence-specific DNA bindingH3F3A;RUNX2;H3F3B;TFAP2B;RBPJ;TP53;HNF4A;RUVBL2;PAX6
RNA polymerase II transcription factor activity, sequence-specific DNA bindingPOU5F1;PAX6A;FOXQ1A;ETV5B;MAZ;SP3A;FOXJ1B;ETV2;ELF5
bHLH transcription factor bindingSOX9;LMO2;FOXH1;SIRT1;IKZF4;USF2;RUNX2;TCF4;TCF12
chromatin bindingBAHD1;CSNK2B;NKX2-5;HMGB3;RELA;RAN;SKOR2;MED12;CDCA5
histone deacetylase bindingHDAC4;TOP2B;TCF21;PHB;ZNHIT1;CBX5;KAT2B;ANKRD1;NKX3
protein bindingLTC4S;PARK2;AACS;PPP2R4;PHF20L1;MPDZ;POLR2E;PTPN14;CADPS
protein domain specific bindingHIST1H4K;ATN1;YWHAQA;FOXH1;CALM;WNT3;MTOR;DRD3;FOXA1
repressing transcription factor bindingTBP;HMGB1;SKI;ARNTL;PARK7;MAGEA2;HDAC7A;CTBP1;CTNNB1
transcription factor activity, sequence-specific DNA bindingTP63;SREBF1;HOMEZB;TAL1;RORCB;ZNF75D;FLI1B;RFX5;ZNF383
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingFOS;GCM1;MITFA;SOX12;SFPI1;SOX1;HNF4A;SOX9;MEIS3

RUNX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RUNX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RUNX2.

PIN1; TP73; SMAD6; SMAD5; SMURF1; MYC

Li, YJ; El Mozen, LA; et al. Transforming growth factor beta 3 involved in the pathogenesis of synovial chondromatosis of temporomandibular joint. SCIENTIFIC REPORTS 5:-(2015).
Xu, LL; Liu, Y; et al. U0126 promotes osteogenesis of rat bone-marrow-derived mesenchymal stem cells by activating BMP/Smad signaling pathway. CELL AND TISSUE RESEARCH 359:537-545(2015).
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