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GNB2L1

Official Full Name

guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
Overview

Seems to bind protein kinase C acting as an intracellular receptor to anchor the activated PKC to the cytoskeleton. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and ITGB1, serves as a platform for SRC activation or inactivation. May play an important role in the developing brain and neuronal differentiation.
Synonyms

GNB2L1; guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1; guanine nucleotide-binding protein subunit beta-2-like 1; Gnb2 rs1; H12.3; RACK1; Receptor for Activated C Kinase 1; lung cancer oncogene 7; proliferation-inducing gene 21; human lung cancer oncogene 7 protein; receptor of activated protein kinase C 1; cell proliferation-inducing gene 21 protein; guanine nucleotide-binding protein subunit beta-like protein 12.3; protein homologous to chicken B complex protein, guanine nucleotide binding; HLC-7; PIG21; Gnb2-rs1;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
MBP
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GNB2L1-1375H	Recombinant Human Guanine Nucleotide-Binding Protein Subunit Beta-2-Like 1, His-tagged	E.coli	His		Inquiry
Human	GNB2L1-30327TH	Recombinant Human GNB2L1, His-tagged	E.coli	His		Inquiry
Human	GNB2L1-465H	Recombinant Human GNB2L1 protein, His&MBP-tagged	E.coli	His/MBP	Met1-Arg317	Inquiry
Human	GNB2L1-5862HCL	Recombinant Human GNB2L1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	GNB2L1-2655H	Recombinant Human GNB2L1 protein, His-tagged	E.coli	His	131-317 aa	$319 / 25ug
Mouse	GNB2L1-7028M	Recombinant Mouse GNB2L1 Protein	Mammalian Cell	His		Inquiry
Mouse	GNB2L1-3767M	Recombinant Mouse GNB2L1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	GNB2L1-3767M-B	Recombinant Mouse GNB2L1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	GNB2L1-9012Z	Recombinant Zebrafish GNB2L1	Mammalian Cell	His		Inquiry
Chicken	GNB2L1-1197C	Recombinant Chicken GNB2L1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
GNB2L1 Related Articles
GNB2L1 Related Research Area

GNB2L1 involved in several pathways and played different roles in them. We selected most pathways GNB2L1 participated on our site, such as Androgen receptor signaling pathway, BDNF signaling pathway, CXCR4-mediated signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNB2L1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Androgen receptor signaling pathway	MYST2;RNF6;PIAS3;SMAD3B;CREBBP;CCDC102A;PATZ1;SVILA;POU2F1B
BDNF signaling pathway	GRIP1;IGF2BP1;EIF4E;JAK2;EGR1;BCL2L11;CFL1;EEF2;CDK5
CXCR4-mediated signaling events	CSK;DNM1;GNB2L1;CFL1;GNA13;ARR3;JAK2;MAPKAP1;ADRBK1
Death Receptor Signalling	FAM105B;RBCK1;TAX1BP1B;SHRPRBCK1R;OTULINB;TAB1;SHARPIN;TAX1BP1;USP2
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	COPS5;HIF1AN;NAA10;GNB2L1;HIF3A
IGF1 pathway	GNB2L1;GRB10
IL-3 Signaling Pathway	GATA2;GSK3AB;GNB2L1;PILRB;KCNIP3;CISH;BMX;GATA1A;GATA1
Interferon type I	GNB2L1;PIAS3

GNB2L1 has several biochemical functions, for example, SH2 domain binding, cysteine-type endopeptidase activator activity involved in apoptotic process, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GNB2L1 itself. We selected most functions GNB2L1 had, and list some proteins which have the same functions with GNB2L1. You can find most of the proteins on our site.

Function	Related Protein
SH2 domain binding	LCK;SKAP1;TRPV4;PTK2;PAG1;CTR9;NLK;DLC1;SQSTM1
cysteine-type endopeptidase activator activity involved in apoptotic process	RPS27L;NOD1;CASP1;APAF1;GNB2L1;PYCARD;CARD8;NLRP12;NLRP1
enzyme binding	AXIN1;PRKDC;LAMP1;PDE4DIP;PARP1;HINFP;UGT1A3;HIST1H2AK;SCARB2
ion channel inhibitor activity	PDZD3;ENSA;KCNMB2;STOML1;GNB2L1;KCNV1;RSC1A1
poly(A) RNA binding	ALKBH5;RBPMS;LUZP4;LSM4;MRPL1;HIST1H4A;RBM4B;BZW1;RPS2
protein binding	GATAD2A;DOHH;UBR1;SFN;DNMT1;FRMPD1;CCND1;ANKRD54;CHD8
protein complex scaffold	MPP7;MAGI3;WWC3;MAGI1B;AKAP13;AXIN1;DISC1;ISCU;SLC9A3R2
protein homodimerization activity	UGT1A7;DGAT2;CRTAM;CAMK2B;PDGFA;SLC4A1;VEGFB;TBX18;ZBTB16
protein kinase C binding	AVPR1A;FEZ1;HAND2;LDB3;TOP2B;CASQ2;AKT1;C1QBP;SQSTM1
protein phosphatase binding	MAP3K5;VRK3;ITGA1;KCNN4;DLG4;PARD3;DLG3;TP53;HSF4
protein tyrosine kinase inhibitor activity	GNB2L1;FGFR1OP;IBTK
receptor binding	AMH;ECI2;AKAP9;HAMP;SERPINE1;PTK2BB;PCSK1N;NCR3;MCHR1
receptor tyrosine kinase binding	ANGPT4;FIZ1;ELMO2;DOCK4;TRP53;SHC4;SOCS5;FNTA;ZFP259
signaling adaptor activity	HOMER1;SH2B3;GNB2L1;AFAP1L2;SH2B1;SH2B2;MPP7;LDLRAP1

GNB2L1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNB2L1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GNB2L1.

DYNLL1; VHL; PPID; bzlf1_ebvb9

Sun, Y; Tao, Y; et al. The schizophrenia/bipolar disorder candidate gene GNB1L is regulated in human temporal cortex by a cis-acting element located within the 3'-region. NEUROSCIENCE BULLETIN 31:43-52(2015).

Guiry, A; Flynn, D; et al. Testes and brain gene expression in precocious male and adult maturing Atlantic salmon (Salmo salar). BMC GENOMICS 11:-(2010).

Phospholipases, Small GTPases, and Other Molecules in the Akt Pathway