RANGAP1
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Official Full Name
Ran GTPase activating protein 1
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Overview
RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle. -
Synonyms
RANGAP1; Ran GTPase activating protein 1; SD, segregation distorter homolog (Drosophila); ran GTPase-activating protein 1; Fug1; KIAA1835; segregation distortion; segregation distorter homolog; SD; MGC20266;
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- Involved Pathway
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- Interacting Protein
- RANGAP1 Related Articles
- RANGAP1 Related Research Area
RANGAP1 involved in several pathways and played different roles in them. We selected most pathways RANGAP1 participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with RANGAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA transport | EIF1AY;CYFIP2;THOC7;EIF2B2;SUMO3A;PABPC3;EIF3JB;TPR;EIF4E2 |
RANGAP1 has several biochemical functions, for example, GTPase activator activity, Ran GTPase binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RANGAP1 itself. We selected most functions RANGAP1 had, and list some proteins which have the same functions with RANGAP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activator activity | ARHGAP4;RALBP1;RIC8A;NF1;STXBP5L;SIPA1L1;BAI3;DEPDC1A;TBC1D4 |
| Ran GTPase binding | TNPO2;XPOT;RANGAP1;DPY19L2;XPO7;CSE1L;RANBP10;IPO9;XPO1 |
| protein binding | PAGE2;KCP;BAHD1;MNDA;METTL15;OAZ2;RUNDC3A;DUSP1;ARHGEF3 |
| ubiquitin protein ligase binding | GLMN;EGFR;CKB;PRKACA;UBE2N;AMBRA1;PML;PTPN22;CHEK2 |
RANGAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RANGAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RANGAP1.
UBE2I; SUMO1; Ranbp2; NXF1; GNAI1; HLA-B; GABARAPL2
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