RBP4
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Official Full Name
retinol binding protein 4, plasma
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Overview
This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. -
Synonyms
RBP4; retinol binding protein 4, plasma; RDCCAS; retinol-binding protein 4; RBP; PRBP; plasma retinol-binding protein; retinol-binding protein 4, interstitial; Retinol-binding protein 4; Plasma retinol-binding protein;
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- C
- 6×His
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- RBP4 Related Articles
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What is rbp4 protein?
The RBP4 protein, also known as Retinol-binding protein 4, is a transporter protein that binds to retinol (vitamin A) in the blood and facilitates its transport to target tissues. It is mainly produced by the liver and secreted into the bloodstream. RBP4 plays a crucial role in maintaining vitamin A homeostasis and regulating its distribution in the body. It has been implicated in various physiological processes, including vision, embryonic development, immune function, and glucose and lipid metabolism. Alterations in RBP4 levels have been associated with several diseases, such as diabetes, obesity, and age-related macular degeneration.
What is the function of rbp4 protein?
The main function of RBP4 is to maintain the proper levels and distribution of retinol, which is essential for various biological processes such as vision, cell growth, immune function, and gene expression. RBP4 helps to protect retinol from degradation and ensures its efficient delivery to target tissues. Additionally, RBP4 has been implicated in the regulation of insulin sensitivity and glucose metabolism. Abnormal levels of RBP4 have been associated with certain metabolic disorders, such as insulin resistance, type 2 diabetes, and obesity.
Rbp4 related signaling pathway
Rbp4 has also been implicated in metabolic regulation and insulin resistance. It has been shown that increased levels of Rbp4 in the bloodstream can contribute to the development of insulin resistance, a hallmark of type 2 diabetes. Rbp4 may interfere with insulin signaling pathways, leading to impaired glucose metabolism and insulin sensitivity.
Rbp4 Related Diseases
- Insulin resistance and type 2 diabetes: Studies have shown that elevated levels of Rbp4 in the blood are associated with insulin resistance, impaired glucose metabolism, and an increased risk of developing type 2 diabetes. Rbp4 may interfere with insulin signaling pathways and contribute to insulin resistance.
- Obesity: Increased levels of Rbp4 have been observed in individuals with obesity. Rbp4 may play a role in the development of insulin resistance and metabolic dysfunction associated with obesity.
- Biomarker for insulin resistance: Elevated levels of Rbp4 have been associated with insulin resistance and type 2 diabetes. Therefore, Rbp4 has been studied as a potential biomarker for these conditions. Measuring the levels of Rbp4 in blood samples can provide insights into the risk or progression of insulin resistance and diabetes.
- Therapeutic target in metabolic disorders: The dysregulation of Rbp4 has been implicated in the development of metabolic syndromes, such as obesity, insulin resistance, and fatty liver disease. Targeting Rbp4 or its signaling pathways may offer therapeutic potential for treating these conditions. Modulating the levels or activity of Rbp4 could potentially improve metabolic health.
Biomedical Application of rbp4 Protein
- Biomarker for insulin resistance: Elevated levels of Rbp4 have been associated with insulin resistance and type 2 diabetes. Therefore, Rbp4 has been studied as a potential biomarker for these conditions. Measuring the levels of Rbp4 in blood samples can provide insights into the risk or progression of insulin resistance and diabetes.
- Diagnostic tool for vitamin A deficiency: As Rbp4 is responsible for transporting retinol, its levels in the blood can indicate the availability of vitamin A. Low levels of Rbp4 may suggest vitamin A deficiency. Therefore, Rbp4 has been explored as a diagnostic marker for identifying individuals who have insufficient vitamin A levels.
- Therapeutic target in metabolic disorders: The dysregulation of Rbp4 has been implicated in the development of metabolic syndromes, such as obesity, insulin resistance, and fatty liver disease. Targeting Rbp4 or its signaling pathways may offer therapeutic potential for treating these conditions. Modulating the levels or activity of Rbp4 could potentially improve metabolic health.
High Purity
Fig1. SDS-PAGE (RBP4-442H)
High Bioactivity & Detection Sensitivity
Fig2. Measured by its binding ability in a functional ELISA. Immobilized Human RBP4 Protein at 2 μg/mL (100 μL/well) can bind RBP4 Rabbit mAb with a linear range of 0.12-2.1 ng/mL.
(Simone K Frey, 2008)
Fig3. Representative polyacrylamide gel electrophoresis-immunoblotting of apo- and holo-RBP4 bands in serum of controls, patients with chronic liver disease (CLD) and chronic kidney disease (CKD). Relative amounts were calculated by comparing the intensity of the apo-band to the holo-RBP4 bands of each lane and are displayed as percentage of total intensity per lane.
(Yanmin Chen, 2017)
Fig4. Serum RBP4, retinol, and RBP4:retinol ratio in GDM and apo-RBP4-injected pregnant rats. d–f Normal dams were divided into two groups (n = 4 per group) and intraperitoneally injected five times with 200 μL of recombinant RBP4 or PBS.
(Zhiwei Xu, 2022)
Fig5. The serum RBP4 levels and retinal RBP4 levels between DM and NDM groups. (d) Retinal RBP4 expression were elevated in DM mice at 3 months after diabetes onset. Immunofluorescence staining images of RBP4 (green), DAPI (blue), and merge in each group.
RBP4 involved in several pathways and played different roles in them. We selected most pathways RBP4 participated on our site, such as Disease, Diseases associated with visual transduction, Diseases of signal transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with RBP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Disease | FMOD;RCC1;OPN1LW;PPIAL4A;HDAC5;OPN1MW2;EPM2A;AP2S1;AP2A1 |
| Diseases associated with visual transduction | RLBP1;OPN1LW;OPN1SW;TTR;OPN1MW;STRA6;RBP1;OPN1MW2;RBP4 |
| Diseases of signal transduction | JAG1;OPN1SW;KREMEN1;JAG2;FGFR1OP2;CCNC;CDC37;HEY2;KREMEN2 |
| Retinoid cycle disease events | STRA6;RBP1;RLBP1;RBP4 |
| Retinoid metabolism and transport | BCO2A;LRP12;CLPS;RBP1;AKR1C6;RBP4;LRP10;RBP2A;APOC2 |
| SREBP signalling | INSIG1;RBP4;RNF139;INSIG2;SEC23B;DBI |
| Signal Transduction | BCL9;FSTL3;PNOC;ARHGEF25;NMU;ARHGAP40;PDE10A;SAGB;GPR177 |
| The canonical retinoid cycle in rods (twilight vision) | RPE65A;ABCA4A;MYO7A;RPE65B;STRA6;RBP3;RBP4;MYO7AA;RLBP1 |
RBP4 has several biochemical functions, for example, protein binding, protein heterodimerization activity, retinal binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RBP4 itself. We selected most functions RBP4 had, and list some proteins which have the same functions with RBP4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | DCAF8;MARCH2;GRM6;PPP2R4;DCAF7;TGFB2;AK8;PLSCR4;HELT |
| protein heterodimerization activity | PDSS2;SLC3A1;HIST1H3C;ATP4A;BTBD11A;HIST2H4A;USF2;MEIS1;SOX8 |
| retinal binding | CRABP1;RBP4;RBP3;CRABP2;RBP7;RBP1;RBP2B;RBP2;RBP5 |
| retinol binding | C8G;LRAT;RBP7;RBP5;RBP3;CRABP1;RBP1;RBP4;ADH7 |
| retinol transporter activity |
RBP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RBP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of RBP4.
TTR; TTR; GRB2; q9wmx2-pro_0000037550
- Q&As
- Reviews
Q&As (5)
Ask a questionStudies have indicated a link between elevated RBP4 levels and a decreased risk of certain cancers, although more research is needed in this area.
Some studies suggest a potential association between RBP4 levels and neurodegenerative disorders like Alzheimer's disease.
RBP4 has been investigated in gestational diabetes, showing potential as a marker for metabolic complications during pregnancy.
While RBP4 shows promise as a biomarker, its clinical utility is still under investigation and requires further validation.
Yes, research has shown that RBP4 levels can differ between genders, potentially affecting metabolic health differently.
Customer Reviews (3)
Write a reviewThe manufacturer's dedicated and knowledgeable support team is readily available to address any concerns, provide guidance, and offer timely solutions.
In addition to its impeccable quality, the manufacturer of the RBP4 protein provides outstanding technical support that can efficiently resolve any challenges encountered during my experiments.
Such attentive support significantly minimizes potential setbacks and facilitates a seamless and efficient experimental process.
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