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RFWD2

  • Official Full Name

    ring finger and WD repeat domain 2

  • Overview

    E3 ubiquitin-protein ligase RFWD2 is an enzyme that in humans is encoded by the RFWD2 gene. RFWD2 has been shown to interact with C-jun.
  • Synonyms

    RFWD2; ring finger and WD repeat domain 2; E3 ubiquitin-protein ligase RFWD2; COP1; FLJ10416; RNF200; Constitutive photomorphogenesis protein 1 homolog; COP; hCOP1; RFWD2_HUMAN; RING finger and WD repeat domain protein 2; RING finger protein 200; OTTHUMP00000032911; OTTHUMP00000032913; OTTHUMP00000235258; putative ubiquitin ligase COP1; constitutive photomorphogenic protein (COP1); constitutive ph; RP11-318C24.3;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Myc|DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RFWD2-186H Recombinant Human RFWD2 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human RFWD2-185H Recombinant Human RFWD2 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human RFWD2-170H Recombinant Human RFWD2 protein, His-tagged E.coli His 1-731aa
Mouse RFWD2-14110M Recombinant Mouse RFWD2 Protein Mammalian Cell His
Mouse RFWD2-7547M Recombinant Mouse RFWD2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse RFWD2-7547M-B Recombinant Mouse RFWD2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque RFWD2-3861R Recombinant Rhesus monkey RFWD2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque RFWD2-3678R-B Recombinant Rhesus Macaque RFWD2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque RFWD2-3678R Recombinant Rhesus Macaque RFWD2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish RFWD2-5627Z Recombinant Zebrafish RFWD2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • RFWD2 Related Articles
  • RFWD2 Related Research Area

RFWD2 involved in several pathways and played different roles in them. We selected most pathways RFWD2 participated on our site, such as p signaling pathway, Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with RFWD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
p signaling pathwayTP53AIP1;RPRM;TRP53;SIAH1;LRDD;CCNB1;ZMAT3;IGFBP3;SESN2
Ubiquitin mediated proteolysisANAPC4;FBXW11B;UBE2A;UBE2R2;UBE2D2L;CUL3B;MGRN1A;RNF7;SAE1

RFWD2 has several biochemical functions, for example, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity, coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RFWD2 itself. We selected most functions RFWD2 had, and list some proteins which have the same functions with RFWD2. You can find most of the proteins on our site.

Function Related Protein
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activityZNRF3;RNF149;RNF169;G2E3;TRIM41;DTX1;ZNRF2B;RC3H2;RNF180
coenzyme F420-0 gamma-glutamyl ligase activityUBE2IA;ARIH1L;ZNRF3;HECW2;SIAH1A;MYLIPA;MARCH4;NEURL3;ITCHA
coenzyme F420-2 alpha-glutamyl ligase activityTMEM129;ZNRF3;MARCH9;RFWD2;ZNRF2B;SHRPRBCK1R;RNF144AA;RNF149;MYLIPA
ligase activitySIAH1A;ZNRF2B;UBR1;BIRC3;MDM2;LIPT2;TRIM11;RCHY1;BRAP
metal ion bindingCar12;ZNF292B;BMP1B;WT1B;ARSJ;ZNF280D;GFI1AA;ZNF217;GLIS2
protein bindingTSN;CLPX;EID3;CLDN18;STRN;OCLN;RIPK2;DDX18;TBC1D20
protein-glutamic acid ligase activityRAG1;MYLIPB;RNF180;ARIH1L;ZNRF3;MGRN1A;MARCH4;MYLIPA;RNF149
protein-glycine ligase activityTMEM129;RNF187;MARCH4;TTLL3;ARIH1L;MARCH6;NEURL1B;TRIM41;RNF144AB
protein-glycine ligase activity, elongatingDTX1;RNF187;MARCH5L;G2E3;ZNRF2B;LTN1;RAG1;MYLIPB;NEURL3
protein-glycine ligase activity, initiatingSHRPRBCK1R;MUL1A;ARIH1L;RC3H2;RNF144AB;ITCHA;HECW2;LTN1;NEURL3
ribosomal S6-glutamic acid ligase activityUBE2M;MARCH5L;G2E3;RNF180;TMEM129;HERC2;RC3H2;TRIM71;MARCH4
tubulin-glutamic acid ligase activityUBR1;MARCH4;MUL1A;DTX1;UBE2IA;RNF149;ZNRF3;LTN1;RNF169
tubulin-glycine ligase activityUBR1;MGRN1A;TRIM41;RNF144AA;ARIH1L;SIAH2L;MUL1A;SIAH1A;MYLIPA
ubiquitin protein ligase activitySTUB1;TRIM59;RNF7;UBE2N;MED31;TRIM24;RNF146;TRIM71;HECTD2
zinc ion bindingCAR7;PGLYRP6;TRIML1;BRAP;AGBL4;LASP1;PAM;TRIM8A;TADA2A

RFWD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RFWD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RFWD2.

Cowley, AW; Moreno, C; et al. Characterization of biological pathways associated with a 1.37 Mbp genomic region protective of hypertension in Dahl S rats. PHYSIOLOGICAL GENOMICS 46:398-410(2014).
Relogio, A; Thomas, P; et al. Ras-Mediated Deregulation of the Circadian Clock in Cancer. PLOS GENETICS 10:-(2014).
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