RIPK3
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Official Full Name
receptor-interacting serine-threonine kinase 3
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Overview
Receptor-interacting protein 3 (RIP3) contains a N-terminal kinase domain and interacts with RIP. The binding of RIP to RIP3 causes the RIP3/RIP complex to be shuttled into the tumor necrosis factor receptor-1 signaling cascade. RIP3 is known to be a very effective apoptosis inducer. Two novel splice variants of RIP3 have been discovered, RIP3 beta and RIP3 gamma, that have shown to decrease apoptosis related to full length RIP3. RIP3 gamma has been shown to be significantly up-regulated in colon and lung cancers and may play a role in tumorigenesis. -
Synonyms
RIPK3; receptor-interacting serine-threonine kinase 3; receptor-interacting serine/threonine-protein kinase 3; RIP3; RIP-3; RIP-like protein kinase 3; receptor interacting protein 3; receptor-interacting protein 3;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Sf9 Insect Cell
- Wheat Germ
- Yeast
- GST
- His
- His (Fc)
- Avi
- Myc
- His|T7
- SUMO
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- RIPK3 Related Research Area
RIPK3 involved in several pathways and played different roles in them. We selected most pathways RIPK3 participated on our site, such as Activated TLR4 signalling, Cytosolic DNA-sensing pathway, Cytosolic sensors of pathogen-associated DNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with RIPK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Activated TLR4 signalling | JUN;CHUK;UBE2V1;DUSP4;TIRAP;CREB1B;PELI1;TICAM1;TLR6 |
| Cytosolic DNA-sensing pathway | POLR3H;IRF3;DDX58;IL18;MB21D1;IKBKE;IL6;NFKBIAB;IFNPHI3 |
| Cytosolic sensors of pathogen-associated DNA | SAA1;NLRP4B;DHX9;CRCP;POLR3F;APPB;S100B;APPA;NLRP4E |
| IKK complex recruitment mediated by RIP1 | |
| Immune System | SIGLEC6;KIF3C;RAP1GAP2;TRIM5;USP18;TRIM69;AP1S1;KLRF1;PPIAL4A |
| Innate Immune System | S100B;FCN1;TXNIP;Txn1;NCKIPSD;SIGLEC15;DDX41;POLR3G;HBL3 |
| MyD88-independent TLR3/TLR4 cascade | RIPK3;TANK |
| Programmed Cell Death | BCAP31;DBNL;Gzmg;PKP1;DNM1L;DIABLO;GZME;STK26;DSG2 |
RIPK3 has several biochemical functions, for example, ATP binding, NF-kappaB-inducing kinase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RIPK3 itself. We selected most functions RIPK3 had, and list some proteins which have the same functions with RIPK3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | GK5;EGFR;PHKG1B;MAP3K2;EPHA2A;NEK7;NLK;EPHB2;FGFR1B |
| NF-kappaB-inducing kinase activity | MAP3K14;IKBKE;IRAK1;RIPK3;ALPK2;ALK;PPP4C |
| identical protein binding | SH3GL2;FBLN1;MID1;APLP2;GOT1;RPE;TPCN1;PLIN5;TPD52L1 |
| protein binding | NRF1;SPRTN;MAPK14;SND1;ENTPD1;TOMM70A;MUS81;DBF4B;TRIM43 |
| protein complex binding | UQCRC2;PPP4C;ULK1;TUB;SIX2;RAN;IGBP1;GNB1;TG |
| protein kinase activity | DAPK2A;CSNK1D;TRIM24;STK26;MYO3A;MAP2K2B;PRKACAB;STK25;TGFBR1A |
| protein serine/threonine kinase activity | PRKACBB;CDK16;MOS;BMPR2A;CAMK2G1;STK16;SBK1;NEK6;RAF1A |
| transcription coactivator activity | TAF7L;RIPK3;RAP2C;JUP;NCOA1;LPIN3;MCIN;SAP130;RUNX1 |
RIPK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RIPK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of RIPK3.
RIPK1
- Q&As
- Reviews
Q&As (5)
Ask a questionRIPK3 activation can lead to the release of pro-inflammatory cytokines, contributing to inflammation in various tissues.
Yes, researchers are exploring the therapeutic potential of targeting RIPK3 to modulate cell death pathways and control inflammation in diseases.
Yes, dysregulation of RIPK3 is linked to several diseases, including neurodegenerative disorders, inflammatory diseases, and certain types of cancers.
In certain cancers, RIPK3 dysregulation can promote cell survival, contributing to tumor growth and resistance to cell death.
Yes, some clinical trials are investigating drugs that target RIPK3 for conditions such as inflammatory diseases and cancer.
Customer Reviews (3)
Write a reviewTheir team of experts possesses an in-depth understanding of the protein and its applications, which proves instrumental in troubleshooting and optimizing experimental protocols.
The manufacturer's responsive and knowledgeable support system promptly addresses any questions or concerns I may have, greatly streamlining my research process.
the manufacturer's dedication to innovation and continuous improvement stands out.
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