RORC
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Official Full Name
RAR-related orphan receptor C
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Overview
The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
RORC; RAR-related orphan receptor C; TOR; RORG; RZRG; NR1F3; RZR-GAMMA; nuclear receptor ROR-gamma; nuclear receptor RZR-gamma; retinoic acid-binding receptor gamma; retinoid-related orphan receptor gamma; RAR-related orphan receptor C, isoform a; RAR-related orphan nuclear receptor variant 2; nuclear receptor subfamily 1 group F member 3;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- E. coli
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect cell
- Insect Cell
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- Yeast
- Flag
- GST
- His
- His (Fc)
- Avi
- His|Flag
- His|SUMO
- Myc
- DDK
- Myc|DDK
- N/A
- N
- SUMO
- Involved Pathway
- Protein Function
- Interacting Protein
- RORC Related Articles
- RORC Related Research Area
- RORC Related Signal Pathway
RORC involved in several pathways and played different roles in them. We selected most pathways RORC participated on our site, such as Circadian rhythm, Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with RORC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Circadian rhythm | PRKAG3;RBX1;CRY2;PER3;SKP1;PRKAG1;RORC;PRKAB2;FBXL3 |
| Inflammatory bowel disease (IBD) | IL12A;HLA-DQB1;IL12B;TLR4;HLA-DRB1;IL6;HLA-DRB4;HLA-DRA;IL17F |
RORC has several biochemical functions, for example, DNA binding, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding, oxysterol binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RORC itself. We selected most functions RORC had, and list some proteins which have the same functions with RORC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | ZNF358;ZFP511;ERCC2;FOXB1B;ZFP41;H2AFJ;RDM1;CHTF18;ZFP191 |
| RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding | NR4A1;RORAA;HNF4G;ESR2;NR2F6B;NR4A2B;RORC;NR2F2;NR5A1B |
| oxysterol binding | RORA;GPR183;OSBP;OSBPL5;RORC |
| protein binding | MS4A12;EEA1;SCRIB;TAL1;WIPF1;HIPK4;HSPA14;THBS1;C1QL1 |
| sequence-specific DNA binding | SOX6;TBX5;JUNBB;FOXO1A;POU1F1;ZNF35;FOXO6;ENG2A;NKX2-8 |
| steroid hormone receptor activity | NR2E1;RXRGA;RARB;RORCA;NR6A1A;RORB;NR4A2A;PPARDB;ESRRGB |
| transcription factor activity, direct ligand regulated sequence-specific DNA binding | RORA;RORC |
| transcription factor activity, sequence-specific DNA binding | ZNF500;SPZ1;ZNF691;SPI1B;FOXA;TCF7L1B;ZC3H8;ZKSCAN3;EGR2 |
| zinc ion binding | CAR1;TEX13A;DPP3;RNF38;PHF1;PGLYRP1;ZDHHC2;KDM5A;PGLYRP5 |
RORC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RORC here. Most of them are supplied by our site. Hope this information will be useful for your research of RORC.
Clock; Arntl; NCOA1; CREBBP; PPARGC1A; 20-hydroxycholesterol; 25-hydroxycholestero; (22r)-22-hydroxycholesterol; BHLHE40; Per2; EVI2A; PPP2R1A; PPP2R1B; PPP1CC; PPP1CA; PPP1CB; PPP2CA
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