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RSPO2

  • Official Full Name

    R-spondin 2

  • Overview

    R-spondins (RSPOs), such as RSPO2, are secreted proteins that regulate beta-catenin (CTNNB1; MIM 116806) signaling (Kim et al., 2006 [PubMed 16357527]).[supplied by OMIM, Mar 2008]
  • Synonyms

    RSPO2; R-spondin 2; CRISTIN2; R-spondin-2; R-spondin 2 homolog; roof plate-specific spondin-2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Mamanlian cells
  • Mammalian Cell
  • Mammalian cells
  • Fc
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RSPO2-480H Active Recombinant Human RSPO2 Protein, Fc-tagged HEK293 Fc
Human RSPO2-866H Active Recombinant Human RSPO2 Protein, His-tagged Mammalian cells His Gln22-Gly205
Human RSPO2-171H Active Recombinant Human RSPO2 Protein CHO N/A
Human RSPO2-2454H Recombinant Human RSPO2, His-tagged E.coli His C-term-214aa
Human RSPO2-42HCL Recombinant Human RSPO2 HEK293T cell lysate HEK293T Myc/DDK
Human RSPO2-1645HCL Recombinant Human RSPO2 cell lysate Human Cell N/A
Human RSPO2-4013H-B Recombinant Human RSPO2 Protein Pre-coupled Magnetic Beads HEK293
Human RSPO2-1803HFL Recombinant Full Length Human RSPO2, Flag-tagged Mamanlian cells Flag
Human RSPO2-4013H Recombinant Human RSPO2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Rspo2-850M Active Recombinant Mouse Rspo2 CHO N/A Met1-Gly205
Mouse RSPO2-14553M Recombinant Mouse RSPO2 Protein Mammalian Cell His
Mouse Rspo2-956M Recombinant Mouse Rspo2 Protein, Fc-tagged HEK293 Fc
Mouse RSPO2-7833M-B Recombinant Mouse RSPO2 Protein Pre-coupled Magnetic Beads HEK293
Mouse RSPO2-7833M Recombinant Mouse RSPO2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish RSPO2-8354Z Recombinant Zebrafish RSPO2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • RSPO2 Related Research Area
  • RSPO2 Related Signal Pathway

RSPO2 involved in several pathways and played different roles in them. We selected most pathways RSPO2 participated on our site, such as Regulation of FZD by ubiquitination, Signal Transduction, Signaling by Wnt, which may be useful for your reference. Also, other proteins which involved in the same pathway with RSPO2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Regulation of FZD by ubiquitinationLGR5;LGR6;LGR4;RSPO2;RNF43;ZNRF3;RSPO1;FMNL3;RSPO4
Signal TransductionCALCB;NPS;ANXA1A;PRICKLE1B;SST;CDC42EP2;RNF41;RGS17;HEYL
Signaling by WntSRY;AES;TLE3B;FMNL3;SOX7;CCDC88C;RSPO2;TNKS;PYGO1
TCF dependent signaling in response to WNTTNKS2;ASH2L;RBBP5;C;SOX7;RSPO4;RSPO1;LGR4;LGR6

RSPO2 has several biochemical functions, for example, G-protein coupled receptor binding, heparin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RSPO2 itself. We selected most functions RSPO2 had, and list some proteins which have the same functions with RSPO2. You can find most of the proteins on our site.

Function Related Protein
G-protein coupled receptor bindingGNAI2B;AKAP5;GNA13B;USP20;NPFF;PSAP;GHRL;NMS;APLN
heparin bindingTHBS2;ADAMTS3;LIPI;IMPG2;GREM2;COL13A1;FGF14;PRELP;HDGF
protein bindingSQSTM1;C22orf28;MPG;BBS9;TMEM59;RAB11FIP3;PHF17;NCF2;ATP5O
receptor bindingDRD1A;F7;ACOT2;FGF6A;CSK;SNX17;PVRL2;MYO1C;ADIPOQ

RSPO2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RSPO2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RSPO2.

KRTAP10-4; KRTAP10-7; KRTAP10-9; PLEKHF2; SUV39H1; JMJD6

  • Q&As
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