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RUNX1

  • Official Full Name

    runt-related transcription factor 1

  • Overview

    Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms

    RUNX1; runt-related transcription factor 1; AML1; CBFA2; EVI-1; AMLCR1; PEBP2aB; AML1-EVI-1; CBF-alpha-2; PEA2-alpha B; PEBP2-alpha B; oncogene AML-1; AML1-EVI-1 fusion protein; acute myeloid leukemia 1 protein; SL3-3 enhancer factor 1 alpha B subunit; SL3/AKV core-binding factor alpha B subunit; core-binding factor, runt domain, alpha subunit 2; polyomavirus enhancer-binding protein 2 alpha B subunit;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Arg
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • His|T7
  • MYC
  • DDK
  • N/A
  • N
  • SUMO
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RUNX1-27497TH Recombinant Human RUNX1 Wheat Germ N/A 102 amino acids
Human RUNX1-2471H Recombinant Human RUNX1, GST-tagged E.coli GST 214-277aa
Human RUNX1-263H Recombinant Human RUNX1 Mammalian Cell His
Human RUNX1-148H Recombinant Human RUNX1 protein, Arginine-tagged E.coli Arg
Human RUNX1-8209H Recombinant Human RUNX1 protein, His & T7-tagged E.coli His/T7 Met1~Phe232 (Accession # Q01196)
Human RUNX1-2112HCL Recombinant Human RUNX1 293 Cell Lysate HEK293 N/A
Human RUNX1-2111HCL Recombinant Human RUNX1 293 Cell Lysate HEK293 N/A
Human RUNX1-1928H Recombinant Human RUNX1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human Runx1-3454H Recombinant Human Runx1 protein, His&Myc-tagged E.coli His&Myc 1-453aa
Human RUNX1-188HFL Active Recombinant Full Length Human RUNX1 Protein, C-Flag-tagged Mammalian cells Flag
Human RUNX1-6649H Recombinant Human RUNX1 Protein (Met1-Tyr480), N-His and SUMO tagged E.coli N-His and SUMO Met1-Tyr480
Human RUNX1-1928H-B Recombinant Human RUNX1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Runx1-783M Recombinant Mouse Runx1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat RUNX1-5201R Recombinant Rat RUNX1 Protein Mammalian Cell His
Rat RUNX1-4860R Recombinant Rat RUNX1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat RUNX1-4860R-B Recombinant Rat RUNX1 Protein Pre-coupled Magnetic Beads HEK293
Rat Runx1-2255R Recombinant Rat Runx1 protein, His&Myc-tagged Insect Cell His&Myc 1-450aa
Rat Runx1-3455R Recombinant Rat Runx1 protein, His-tagged E.coli His 1-450aa
Rhesus Macaque RUNX1-4053R Recombinant Rhesus monkey RUNX1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque RUNX1-3870R-B Recombinant Rhesus Macaque RUNX1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque RUNX1-3870R Recombinant Rhesus Macaque RUNX1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish RUNX1-9143Z Recombinant Zebrafish RUNX1 Mammalian Cell His
Chicken RUNX1-6780C Recombinant Chicken RUNX1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • RUNX1 Related Articles
  • RUNX1 Related Research Area
  • RUNX1 Related Signal Pathway

RUNX1 involved in several pathways and played different roles in them. We selected most pathways RUNX1 participated on our site, such as Pathways in cancer, Transcriptional misregulation in cancer, Chronic myeloid leukemia, which may be useful for your reference. Also, other proteins which involved in the same pathway with RUNX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Pathways in cancerBRCA2;LPAR6;FZD5;GNA12;RUNX1T1;RASGRP3;BIRC2;FGF18;LAMA3
Transcriptional misregulation in cancerLYL1;ETV1;RXRG;CCNA1;BCL6;FLT3;ZBTB17;IGF1R;LDB1
Chronic myeloid leukemiaTGFB1;BCL2L1;SOS1;RELA;MAPK1;IKBKG;SMAD3;SHC2;PIK3CA
Acute myeloid leukemiaCEBPA;KRAS;ARAF;LEF1;SOS1;MAPK1;MYC;PIK3R2;IKBKB

RUNX1 has several biochemical functions, for example, DNA binding, transcription coactivator activity, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RUNX1 itself. We selected most functions RUNX1 had, and list some proteins which have the same functions with RUNX1. You can find most of the proteins on our site.

Function Related Protein
DNA bindingZNF559;SURF6;PNN;POLR3K;HIST1H3D;ZBTB44;IRX5;FOXG1C;FOXJ1B
transcription coactivator activityUBE2L3;ELF3;TADA3;ZSCAN1;NR1I2;LPIN1;RB1;MED6;MED23
transcription factor activity, sequence-specific DNA bindingNKX2;POU2F2;ZNF561;ZFP184;ZNF202;NEUROG1;FOXI3A;HSF5;FBXW7
zinc ion bindingUSP45;FHL5;BIRC3;RPH3A;CXXC1;TRIM39;RXRBB;BMP1B;MMP20

RUNX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RUNX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RUNX1.

CDK6; HIPK2; NCOR2; CBFB; ELF2; WWTR1; TAL1

Lindskog, C; Kuhlwilm, M; et al. Analysis of Candidate Genes for Lineage-Specific Expression Changes in Humans and Primates. JOURNAL OF PROTEOME RESEARCH 13:3596-3606(2014).
Ren, TL; Han, ZJ; et al. Association of SLC22A4 Gene Polymorphism with Rheumatoid Arthritis in the Chinese Population. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY 28:206-210(2014).
  • Q&As
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