SART1
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Official Full Name
squamous cell carcinoma antigen recognized
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Overview
This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway. -
Synonyms
SART1; squamous cell carcinoma antigen recognized; squamous cell carcinoma antigen recognised by T cells; U4/U6.U5 tri-snRNP-associated protein 1; Ara1; small nuclear ribonucleoprotein 110kDa (U4/U6.U5); SNRNP110; Snu66; Ara 1; HOMS 1; HOMS1; hSART 1; hSART1; hSnu 66; hSnu66; IgE autoantigen; SART 1; SART1 259; SART1(259) protein; SART1(800) protein; SART1259; Snu 66; Squamous cell carcinoma antigen recognized by T cells 1; U4/U6.U5 tri snRNP associated 110 kDa protein; U4/U6.U5 tri snRNP associated protein 1; SART-1; hSART-1; SNU66 homolog; U4/U6.U5 tri-snRNP-associated 110 kDa protein;
- Cell & Tissue Lysates
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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| Human | SART1-2059HCL | Recombinant Human SART1 293 Cell Lysate | HEK293 | N/A |
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| Mouse | SART1-14679M | Recombinant Mouse SART1 Protein | Mammalian Cell | His |
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| Mouse | SART1-7905M | Recombinant Mouse SART1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | SART1-7905M-B | Recombinant Mouse SART1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | SART1-5232R | Recombinant Rat SART1 Protein | Mammalian Cell | His |
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| Rat | SART1-4891R-B | Recombinant Rat SART1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | SART1-4891R | Recombinant Rat SART1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Zebrafish | SART1-780Z | Recombinant Zebrafish SART1 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- SART1 Related Research Area
SART1 involved in several pathways and played different roles in them. We selected most pathways SART1 participated on our site, such as Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with SART1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Spliceosome | SNRPF;CWC15;LSM7;ISY1;HNRNPA1L2;SF3A2;HNRNPA1;PUF60;SRSF10 |
SART1 has several biochemical functions, for example, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SART1 itself. We selected most functions SART1 had, and list some proteins which have the same functions with SART1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | S100A16;SSB;XRN2;ZRANB2;RPL23A;SUPT6H;GTPBP1;DDX23;RPS27A |
| protein binding | PRKAG1;FGF1;SSTR2;TRAF4;TNP1;SRM;SPRTN;LBX1;DZIP3 |
SART1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SART1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SART1.
UBL5; SNW1; PRPF4; SUMO3; SUMO1; WBP4; Rnf4; CHM; MAX; RNPS1; SF3A2; USP39
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