scarb1
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  • Official Full Name
  • scavenger receptor class B, member 1
  • Background
  • Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester.
  • Synonyms
  • SCARB1; scavenger receptor class B, member 1; CD36; Cla1; SRBI; Srb1; Cla-1; Hdlq1; SR-B1; SR-BI; Cd36l1; Hlb398; mSR-BI; AI120173; D5Ertd460e; scavenger receptor class B member 1; HDL QTL 1; scavenger receptor class B1; scavenger receptor class B type I;
Cat.#:SCARB1-1087HTag:His-SUMO
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SCARB1 Protein (33-443 aa), His-SUMO-tagged
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Cat.#:SCARB1-322HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human SCARB1 Protein (Pro 33 - Tyr 443), Fc-tagged
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Cat.#:SCARB1-467HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human SCARB1 Protein, MYC/DDK-tagged
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Cat.#:Scarb1-699RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Scarb1 Protein, His/GST-tagged
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Cat.#:SCARB1-509HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human SCARB1 protein, Fc-tagged
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Cat.#:SCARB1-846HTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human SCARB1, Fc-His tagged
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Cat.#:SCARB1-848HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human SCARB1, His tagged
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Cat.#:SCARB1-852HTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human Scavenger Receptor Class B, Member 1, Fc-His
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Cat.#:Scarb1-01MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Scarb1, Fc-tagged
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Cat.#:Scarb1-3294MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Scarb1, His-tagged
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Cat.#:Scarb1-849MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Scarb1, His tagged
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Cat.#:Scarb1-859MTag:His/Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Scarb1 Protein, His & Fc-tagged
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Cat.#:SCARB1-5243RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SCARB1 Protein
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Cat.#:SCARB1-9880ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SCARB1
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Cat.#:SCARB1-2699HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human SCARB1 cell lysate
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Cat.#:SCARB1-2684MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse SCARB1 cell lysate
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Cat.#:Scarb1-847MTag:FC/His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Scavenger Receptor Class B, Member 1, Fc-His
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Involved Pathway

SCARB1 involved in several pathways and played different roles in them. We selected most pathways SCARB1 participated on our site, such as Phagosome, Ovarian steroidogenesis, Aldosterone synthesis and secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with SCARB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Phagosome
TUBB2B; SCARB1; H2-AB1; TUBA1B; THBS1; SEC22BA; MHC2DAB; RAB7A; SFTPA1; NOX3
Ovarian steroidogenesis
PRKACG; CYP2J6; AKR1C3; INS2; STAR; PLA2G4D; PRKACB; INS1; FSHR; BMP6
Aldosterone synthesis and secretion
ATF4; CALM3; HSD3B6; PLCB3; ATF6B; DDX1; ATF2; CREB3L3; CYP11A1; SCARB1
Fat digestion and absorption
APOA4; APOB; APOA1; MOGAT2; DGAT2; PLA2G12A; LIPF; SCARB1; PNLIP; AGPAT2
Bile secretion
ADCY6; SLCO1B1; KCNN2; HMGCR; SLC9A3; ADCY7; SLCO1A2; SLCO1A6; ATP1B3; ADCY9
Vitamin digestion and absorption
SLC23A1; APOA1; SCARB1; RBP2; LMBRD1; SLC19A3; SLC52A3; GIF; MMACHC; LRAT
Hepatitis C
GSK3B; IRF1; TP53; RNASEL; EIF3E; OAS1B; MAPK8; TRADD; IFNAR2; PPARA

Protein Function

SCARB1 has several biochemical functions, for example, 1-phosphatidylinositol binding, apolipoprotein A-I binding, apolipoprotein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SCARB1 itself. We selected most functions SCARB1 had, and list some proteins which have the same functions with SCARB1. You can find most of the proteins on our site.
Function
Related Protein
Function 1-phosphatidylinositol binding
Related Protein PLEKHA3; EPB41; ZFYVE1; PICALM; ZFYVE16; PICALMA; CCDC167; MCF2L; EEA1; SYT1
Function apolipoprotein A-I binding
Related Protein SCARB1; LCAT; ABCA1B; ABCA1
Function apolipoprotein binding
Related Protein MAPT; LRP6; ABCA1; LPL; CANX; LRP4; LRP1; LIPC; VLDLR; SCARB1
Function high-density lipoprotein particle receptor activity
Related Protein SCARB1; ILDR1
Function lipopolysaccharide binding
Related Protein TLR4; RNASE7; SCARB1; LBP; P2RX7; TREM2; DROSHA; TRIL; PSMB4; SELP
Function lipopolysaccharide receptor activity
Related Protein PTAFR; LY96; TLR2; TLR4; SCARB1
Function low-density lipoprotein particle binding
Related Protein THBS1; SCARB1; MSR1; PCSK9; SORL1; CDH13; LDLR; COLEC12; SCARF1; LIPC
Function phosphatidylserine binding
Related Protein CPNE6; SYTL2; SDPR; THBS1; GAS6; ANXA13; JPH2; SCARB1; RPE65; MARK1
Function protein binding
Related Protein TSSK4; CSTF2; SUN2; ZFPM1; TRAPPC2L; TACR3; WLS; CXXC1; MMRN2; C6
Function transporter activity
Related Protein FABP7B; SLC15A5; CRABP2; RASSF9; SLC22A1; SEC14L3; SLCO1B2; RBP7; CDH17; SLC15A1B
Function virus receptor activity
Related Protein LAMP1; SELPLG; ITGB1; SLC20A2; CD80; HTR2A; HYAL2; DAG1; CLEC5A; ITGAV

Interacting Protein

SCARB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SCARB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SCARB1.
KRTAP5-9; KRTAP10-9; 1-hexadecanoyl-2-(9z-octadecenoyl)-sn-glycero-3-phosphocholine; p27958-pro_0000037570; APOA1; p26663-pro_0000037533; PRMT2; cona_canen; FLT1