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SCARB1

  • Official Full Name

    scavenger receptor class B, member 1

  • Overview

    Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester.
  • Synonyms

    SCARB1; scavenger receptor class B, member 1; CD36; Cla1; SRBI; Srb1; Cla-1; Hdlq1; SR-B1; SR-BI; Cd36l1; Hlb398; mSR-BI; AI120173; D5Ertd460e; scavenger receptor class B member 1; HDL QTL 1; scavenger receptor class B1; scavenger receptor class B type I;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Others
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • C
  • Fc
  • His
  • Myc
  • DDK
  • Fc|His
  • His (Fc)
  • Avi
  • His|Fc
  • His|GST
  • His|SUMO
  • human|IgG1|Fc
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SCARB1-509H Recombinant Human SCARB1 protein, Fc-tagged HEK293 Fc
Human SCARB1-852H Recombinant Human Scavenger Receptor Class B, Member 1, Fc-His Human Fc/His
Human SCARB1-848H Recombinant Human SCARB1 protein, His-tagged HEK293 His Pro33-Tyr443
Human SCARB1-846H Recombinant Human SCARB1, Fc-His tagged Human Cell Fc/His
Human SCARB1-2699HCL Recombinant Human SCARB1 cell lysate Human Cell N/A
Human SCARB1-322H Recombinant Human SCARB1 protein, Fc-tagged HEK293 human/IgG1/Fc 411
Human SCARB1-1087H Recombinant Human SCARB1 Protein (33-443 aa), His-SUMO-tagged E.coli His/SUMO 33-443 aa
Human SCARB1-138H Recombinant Human SCARB1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human SCARB1-2829H Recombinant Human SCARB1 Full Length Transmembrane protein(Nanodisc) HEK293 N/A
Human SCARB1-6706H Recombinant Human SCARB1 Protein (Pro33-Tyr443), C-Fc tagged Mammalian cells C-Fc Pro33-Tyr443
Human SCARB1-0680H Recombinant Human SCARB1 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Pro33-Tyr443
Human SCARB1-6707H Recombinant Human SCARB1 Protein (Pro33-Tyr443), C-His tagged Mammalian cells C-His Pro33-Tyr443
Human SCARB1-4742H Recombinant Human SCARB1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SCARB1-0681H Recombinant Human SCARB1 protein, Fc-tagged HEK293 Fc Pro33-Tyr443
Human SCARB1-436H Recombinant Human SCARB1 Protein, Fc-tagged HEK293 Fc 552
Human SCARB1-467H Recombinant Human SCARB1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Mouse Scarb1-849M Recombinant Mouse Scarb1 protein(Pro33-Val440), His-tagged HEK293 C-His Pro33-Val440
Mouse Scarb1-01M Recombinant Mouse Scarb1, Fc-tagged HEK293 Fc
Mouse Scarb1-859M Recombinant Mouse Scarb1 Protein, His & Fc-tagged HEK293 His/Fc
Mouse Scarb1-3294M Recombinant Mouse Scarb1, His-tagged Human Cell His
Mouse SCARB1-2684MCL Recombinant Mouse SCARB1 cell lysate Human Cell N/A
Mouse Scarb1-5704M Recombinant Mouse Scarb1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Scarb1-847M Recombinant Mouse Scavenger Receptor Class B, Member 1, Fc-His HEK293 Fc/His
Rat SCARB1-5243R Recombinant Rat SCARB1 Protein Mammalian Cell His
Rat Scarb1-699R Recombinant Rat Scarb1 Protein, His/GST-tagged E.coli His/GST Pro33~Val440
Rat SCARB1-4902R Recombinant Rat SCARB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SCARB1-4902R-B Recombinant Rat SCARB1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish SCARB1-9880Z Recombinant Zebrafish SCARB1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SCARB1 Related Research Area

SCARB1 involved in several pathways and played different roles in them. We selected most pathways SCARB1 participated on our site, such as Phagosome, Ovarian steroidogenesis, Aldosterone synthesis and secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with SCARB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PhagosomeMHC2DCB;TLR2-1;HLA-DRB4;BLB2;RAC1A;ATP6V1AA;CTSSB.1;BLB1;EEA1
Ovarian steroidogenesisSTAR;PRKACB;CYP2J5;HSD3B1;INS2;INS;PRKACG;LHB;LHCGR
Aldosterone synthesis and secretionSTAR;SCARB1;PLCB3;ORAI1;CYP11B2;PRKD3;AGTR1B;DAGLB;PRKACG
Fat digestion and absorptionAPOB;PLA2G1B;AGPAT2;APOA1;PLA2G2A;FABP2;APOA4;PLA2G2D;PLA2G3
Bile secretionSLC27A5;PRKACB;PRKACG;SLC9A3;GNAS;AQP9;ABCB1;ATP1A4;AQP4
Vitamin digestion and absorptionPNLIP;SLC5A6;LMBRD1;APOA4;ABCC1;TCN2;APOB;SLC19A3;LRAT
Hepatitis CBAD;SCARB1;IFNA7;NFKBIA;OAS1B;TNFRSF1A;IFNB1;EIF2AK3;GRB2

SCARB1 has several biochemical functions, for example, 1-phosphatidylinositol binding, apolipoprotein A-I binding, apolipoprotein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SCARB1 itself. We selected most functions SCARB1 had, and list some proteins which have the same functions with SCARB1. You can find most of the proteins on our site.

Function Related Protein
1-phosphatidylinositol bindingSCARB1;PICALMA;CCDC167;SNX9;PICALMB;PLEKHA3;MCF2L;EEA1;SYT1
apolipoprotein A-I bindingABCA1;SCARB1;ABCA1B;LCAT
apolipoprotein bindingLRP4;LPA;CANX;VLDLR;LRP1;LIPC;ABCA1;SCARB1;MAPT
high-density lipoprotein particle receptor activityILDR1;SCARB1
lipopolysaccharide bindingCATHL3;HSPD1;BPIFC;CD6;HMGB1;DROSHA;BPIFA2;TREM2;TLR4
lipopolysaccharide receptor activityLY96;TLR2;TLR4;PTAFR;SCARB1
low-density lipoprotein particle bindingCDH13;SCARF1;LDLR;PCSK9;CRP;COLEC12;ANKRA2;SORL1;THBS1
phosphatidylserine bindingSDPR;CD300A;RASGRP1;FCHO2;PLCD1;SYTL2;ANXA9;SCARB1;OSBPL5
protein bindingDNAJB9;PRKAA1;CD27;CRELD2;PRR16;CA1;KIF20A;RBM23;PMP22
transporter activityRBP2B;SLC25A31;PPIAL4A;AQP11;Slc4a2;LCN2;MUP3;FABP6;SEC22A
virus receptor activityITGAV;NPC1;XPR1;ITGB5;CXCR4;SLC52A2;SERPINB4;GPR172B;SLC10A1

SCARB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SCARB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SCARB1.

KRTAP5-9; KRTAP10-9; 1-hexadecanoyl-2-(9z-octadecenoyl)-sn-glycero-3-phosphocholine; p27958-pro_0000037570; APOA1; p26663-pro_0000037533; PRMT2; cona_canen; FLT1

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