Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

SCN5A

Official Full Name

sodium channel, voltage-gated, type V, alpha subunit
Overview

The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Synonyms

SCN5A; sodium channel, voltage-gated, type V, alpha subunit; HB1; HB2; HH1; IVF; VF1; HBBD; ICCD; LQT3; SSS1; CDCD2; CMD1E; CMPD2; PFHB1; Nav1.5; sodium channel protein type 5 subunit alpha; voltage-gated sodium channel subunit alpha Nav1.5; sodium channel protein cardiac muscle subunit alpha; cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SCN5A-2537H	Recombinant Human SCN5A protein, His-tagged	E.coli	His	422-714 aa	$319 / 25ug
Rat	SCN5A-5268R	Recombinant Rat SCN5A Protein	Mammalian Cell	His		Inquiry
Rat	SCN5A-4927R	Recombinant Rat SCN5A Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	SCN5A-4927R-B	Recombinant Rat SCN5A Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
SCN5A Related Articles

SCN5A involved in several pathways and played different roles in them. We selected most pathways SCN5A participated on our site, such as Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with SCN5A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Adrenergic signaling in cardiomyocytes	GNA11A;PIK3R3B;PPP1CAA;MYL2;PRKACA;ADCY7;CAMK2G1;PPP1CA;SCN1BA

SCN5A has several biochemical functions, for example, ankyrin binding, calmodulin binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SCN5A itself. We selected most functions SCN5A had, and list some proteins which have the same functions with SCN5A. You can find most of the proteins on our site.

Function	Related Protein
ankyrin binding	PLEC;KCTD6;RHAG;NRCAM;RHBG;CDH1;FLNC;PTBP3;OBSCN
calmodulin binding	CAMSAP1;ADD1;MYH11;MTAP6;SPTAN1;IQCB1;PLA2G6;MAPKAPK5;SPTBN1
enzyme binding	TBP;PHKG1;CRB2;IL6R;MAPK14;BIRC7;PDE4DIP;PRKCH;HSPA1B
fibroblast growth factor binding	KLB;GPC1;CEP57;RPS2;FGFBP1;FGFR1;FGFR3;GLG1B;FIBPB
ion channel binding	ARRB1;KCNC1;CALM2;YWHAH;PPP1R9B;SRC;KCNQ1;AKAP6;FHL1
nitric-oxide synthase binding	SNTA1;CD74;DNM2;ACTB;CAV1;SLC14A2;CALM1;DNM3;CALM3
protein binding	SGTB;TTC6;PRICKLE1;RPA2;KLKB1;CLDN8;SLC40A1;NAA35;HSBP1
protein domain specific binding	PLG;AKAP1;NCK1;CBX3;HOXB1;RXRA;YWHAZ;PPARA;VAPA
protein kinase binding	AURKA;CD226;IL31RA;LAX1;TSKS;ATF2;CNPPD1;CDC25C;AKAP7
scaffold protein binding	NLRP1;DSP;KCNA5;GRID2;NLGN3;CACNA1H;NLGN4X;TREM1;ATP2B4
ubiquitin protein ligase binding	ANAPC2;CUL9;CCT2;FZD5;EIF4E2;HSPA9;GABARAPL1;MDM2;BAG5
voltage-gated sodium channel activity	SCN4AA;SCN8AB;SCN8A;SCN2A;SCN1B;HCN2;SCN4A;ASIC4A;SCN1BB
voltage-gated sodium channel activity involved in AV node cell action potential
voltage-gated sodium channel activity involved in Purkinje myocyte action potential	SCN5A;SCN1B
voltage-gated sodium channel activity involved in SA node cell action potential
voltage-gated sodium channel activity involved in bundle of His cell action potential
voltage-gated sodium channel activity involved in cardiac muscle cell action potential	SCN3B;SCN5A;SCN2B;SCN1B

SCN5A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SCN5A here. Most of them are supplied by our site. Hope this information will be useful for your research of SCN5A.

CAMK2D; CALM1; PTPN3

Kaur, K; Zarzoso, M; et al. TGF-beta 1, Released by Myofibroblasts, Differentially Regulates Transcription and Function of Sodium and Potassium Channels in Adult Rat Ventricular Myocytes. PLOS ONE 8:-(2013).

Tarradas, A; Selga, E; et al. A Novel Missense Mutation, I890T, in the Pore Region of Cardiac Sodium Channel Causes Brugada Syndrome. PLOS ONE 8:-(2013).