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SDHA

  • Official Full Name

    succinate dehydrogenase complex, subunit A, flavoprotein (Fp)

  • Overview

    Succinate dehydrogenase (SDH), also known as Complex II or succinate:quinone oxidoreductase, is a key component of the citric acid cycle and the electron transport chain. Specifically, it is involved in the oxidation of succinate. SDH consists of four sub
  • Synonyms

    SDHA; succinate dehydrogenase complex, subunit A, flavoprotein (Fp); SDH2; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; FP; SDHF; flavoprotein subunit of complex II; succinate dehydrogenase complex flavoprotein subunit; PGL5;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bacillus subtilis
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E. coli or Yeast
  • E.coli
  • HEK293
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SDHA-1366H Recombinant Human SDHA Protein, His-SUMO-tagged E.coli His/SUMO
Human SDHA-1367H Recombinant Human SDHA Protein, GST-tagged E.coli GST
Human SDHA-2011HCL Recombinant Human SDHA 293 Cell Lysate HEK293 N/A
Human SDHA-2676H Recombinant Human SDHA Protein, His-tagged E.coli N-His Val4-Ile300
Human SDHA-3476H Recombinant Human SDHA protein, His-tagged E.coli His 44-293aa
Mouse SDHA-14801M Recombinant Mouse SDHA Protein Mammalian Cell His
Mouse SDHA-7966M-B Recombinant Mouse SDHA Protein Pre-coupled Magnetic Beads HEK293
Mouse SDHA-7966M Recombinant Mouse SDHA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Sdha-1714M Recombinant Mouse Sdha protein, His & T7-tagged E.coli His/T7 Val4~Ile300 (Accession # Q8K2B3)
Rat SDHA-5290R Recombinant Rat SDHA Protein Mammalian Cell His
Rat SDHA-4949R Recombinant Rat SDHA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SDHA-4949R-B Recombinant Rat SDHA Protein Pre-coupled Magnetic Beads HEK293
Bacillus subtilis SDHA-0314B Recombinant Bacillus subtilis SDHA protein, His-tagged E. coli or Yeast His
Zebrafish SDHA-11152Z Recombinant Zebrafish SDHA Mammalian Cell His
Chicken SDHA-4804C Recombinant Chicken SDHA Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SDHA Related Articles

SDHA involved in several pathways and played different roles in them. We selected most pathways SDHA participated on our site, such as Citrate cycle (TCA cycle), Oxidative phosphorylation, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with SDHA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Citrate cycle (TCA cycle)OGDHA;SDHDB;SDHD;DLDH;IDH1;PC;SUCLG1;IDH3G;PDHA2
Oxidative phosphorylationATP6V0A4;SDHDA;NDUFC1;ATP4B;Atp5k;NDUFB1;NDUFB10;SDHDB;COX6A2
Metabolic pathwaysPAPSS2;ATP5B;PLD4;UCK1;GFPT2;PFAS;NOS1;GGPS1;CYP2B6
Carbon metabolismACADS;ADPGK;ENO1A;HADHAB;PFKMB;GOT2A;PGAM2;ME3;GLDC
Non-alcoholic fatty liver disease (NAFLD)UQCRFS1;CYCS;COX7A2L;NDUFA2;ADIPOR2;NDUFA13;IL1B;PIK3CA;TNFRSF1A
Alzheimers diseaseITPR2;ATF6;CASP7;NDUFB3;MME;PLCB3;COX7C;UQCRC1;ATP5E
Parkinsons diseaseNDUFS1;NDUFA4;NDUFA12;ATP5F1;UBE1Y1;NDUFB9;ATP5B;ATP5C1;UBE2L3
Huntingtons diseaseREST;NDUFB10;COX6A2;SP1;NDUFA9;COX4I2;DCTN1;COX6B1;NDUFA7

SDHA has several biochemical functions, for example, flavin adenine dinucleotide binding, protein binding, succinate dehydrogenase (ubiquinone) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SDHA itself. We selected most functions SDHA had, and list some proteins which have the same functions with SDHA. You can find most of the proteins on our site.

Function Related Protein
flavin adenine dinucleotide bindingDLDH;NDOR1;FMO2;ACADL;SQLEA;ACOX3;DLD;CYBB;AOX4
protein bindingMAP6;KRT40;SENP3;MAGEA6;BID;ARHGEF7;MED25;WBP1;KCNE3
succinate dehydrogenase (ubiquinone) activitySDHA;SDHB
succinate dehydrogenase activitySDHA;SDHD
contributes_to succinate dehydrogenase activitySDHA;SDHDB;SDHDA

SDHA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SDHA here. Most of them are supplied by our site. Hope this information will be useful for your research of SDHA.

SDHB; HLA-B; IKBKE; FXN; CSNK2B; q5ni74_fratt; rcsC; lysS; 15-deoxy-delta(12,14; GABARAP; MYC; nef; SLC25A5; VCAM1; ARRB2; GABARAPL2; CLPP

Williamson, SR; Eble, JN; et al. Succinate dehydrogenase-deficient renal cell carcinoma: detailed characterization of 11 tumors defining a unique subtype of renal cell carcinoma. MODERN PATHOLOGY 28:80-94(2015).
Grimm, M; Cetindis, M; et al. Association of cancer metabolism-related proteins with oral carcinogenesis - indications for chemoprevention and metabolic sensitizing of oral squamous cell carcinoma?. JOURNAL OF TRANSLATIONAL MEDICINE 12:-(2014).
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