SDHD
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Official Full Name
succinate dehydrogenase complex, subunit D, integral membrane protein
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Overview
Succinate dehydrogenase complex subunit D (SDHD) is a member of the CybS family and is one of four subunits of the succinate dehydrogenase (SDH) complex involved in the electron transport chain of the mitochondria. The specific role of SDH is to transfer electrons from succinate to ubiquinone, and the SDHD subunit is involved in anchoring the SDH complex to the inner mitochondrial membrane. Defective SDHD has been linked to Carney-Stratakis syndrome, a condition characterized by concurrent paraganglioma and gastric stromal sarcomas. -
Synonyms
SDHD; succinate dehydrogenase complex, subunit D, integral membrane protein; PGL, PGL1; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; QPs3; cybS; CII-4; succinate-ubiquinone reductase membrane anchor subunit; succinate-ubiquinone oxidoreductase cytochrome b small subunit; PGL; CBT1; PGL1; SDH4;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Chicken
- Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
- Drosophila melanogaster (Fruit fly)
- Escherichia coli (strain K12)
- Escherichia coli O157:H7
- Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
- Gallus gallus (Chicken)
- Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Ovis aries (Sheep)
- Paracoccus denitrificans
- Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
- Rat
- Rattus norvegicus (Rat)
- Rhesus Macaque
- Rickettsia bellii (strain RML369-C)
- Rickettsia conorii (strain ATCC VR-613 / Malish 7)
- Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
- Rickettsia prowazekii (strain Madrid E)
- Rickettsia typhi (strain ATCC VR-144 / Wilmington)
- Shigella flexneri
- Sus scrofa (Pig)
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- E.coli
- E.coli expression system
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- His
- His (Fc)
- Avi
- His|T7
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- SDHD Related Articles
SDHD involved in several pathways and played different roles in them. We selected most pathways SDHD participated on our site, such as Citrate cycle (TCA cycle), Oxidative phosphorylation, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with SDHD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Citrate cycle (TCA cycle) | DLDH;DLD;SDHDB;IDH2;SDHC;PDHA1;SUCLG1;FH1;PC |
| Oxidative phosphorylation | NDUFS1;UQCR11;ATP5G3;NDUFC2;ATP6V0CB;NDUFA10;NDUFB9;ATP6V1E1B;NDUFA7 |
| Metabolic pathways | ACAA2;MTHFD2;MDH1AA;NDUFV3;NDUFS5;ALAS2;DNMT3AB;OXSR1;DHFRL1 |
| Carbon metabolism | OGDHL;PKM2;ALDOC;PHGDH;HADHAA;HK2;DLDH;AGXTA;ACSS2 |
| Non-alcoholic fatty liver disease (NAFLD) | Il6ra;CASP8;PIK3R1;IL6;LEPR;RELA;NDUFB11;NDUFB9;IL6R |
| Alzheimers disease | COX4I1;UQCR11;FAS;NDUFB8;MT-ATP6;NDUFA8;CALML5;LRP1;NDUFB9 |
| Parkinsons disease | ATP5J;CYCS;UQCRQ;SLC18A1;NDUFB9;UQCRC2;ATP5C1;ATP5A1;NDUFA9 |
| Huntingtons disease | COX4I1;UQCRQ;PLCB4;VDAC1;NDUFS1;NDUFS2;UQCRC2;PPIF;ATP5O |
SDHD has several biochemical functions, for example, electron carrier activity, heme binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SDHD itself. We selected most functions SDHD had, and list some proteins which have the same functions with SDHD. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| electron carrier activity | NDUFA12;ETFDH;GCDHA;ACAD9;CIAPIN1;GLRX;SH3BGRL3;PHGDH;UQCR11 |
| heme binding | CYP19A1;LPO;CYP2V1;CYP46A1;CYP4F22;HBE;HBD;SUOX;PTGS1 |
| metal ion binding | RAG1;CHORDC1;DCST1;ZNF358;ZFP39;SALL1A;ASGR1;SPNA1;ASPHD2 |
| succinate dehydrogenase activity | SDHA;SDHD |
| ubiquinone binding | DHODH;SDHDB;ETFDH;SDHDA;SDHD;SDHB |
SDHD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SDHD here. Most of them are supplied by our site. Hope this information will be useful for your research of SDHD.
SLC25A5
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