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Serpina1a

  • Official Full Name

    serine (or cysteine) peptidase inhibitor, clade A, member 1A

  • Overview

    Alpha 1-Antitrypsin is a 52 kDA serine protease inhibitor (serpin) in blood, which protects tissue from enzymes from inflammatory cells, especially elastase. In certain acute phase inflammatory reactions, A1AT is elevated in order to limit the damage caused by activated neutrophil granulocytes and their enzyme elastase. Disorders of A1AT include A1AT deficiency, a hereditary disorder that can lead to severe tissue breakdown during inflammation. This may result in pulmonary emphysema and liver cirrhosis, in severe cases. Genetic variants of A1AT do occur.
  • Synonyms

    Aat-2; Aat2; Dom1; PI1; Spi1-1; Spi1-3; AAT; alpha-1 protease inhibitor 1; alpha-1-antiproteinase; alpha-1-antitrypsin 1-1; alpha-1-antitrypsin 2; serine (or cysteine) proteinase inhibitor, clade A, member 1a; serine protease inhibitor 1-1; serine protease inhibitor A1a; serpin A1a;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Mouse
  • E.coli
  • HEK293
  • Human Cell
  • Mammalian cells
  • C
  • hFc
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Mouse Serpina1a-304M Active Recombinant Mouse Serpina1a, His-tagged Mammalian cells His
Mouse Serpina1a-471M Active Recombinant Mouse Serpina1a protein HEK293 N/A Met1-Lys413
Mouse Serpina1a-473M Recombinant Mouse Serpina1a, His-tagged Human Cell His Met1-Lys413
Mouse Serpina1a-472M Active Recombinant Mouse Serpina1a protein(Met1-Lys413), hFc-tagged HEK293 C-hFc Met1-Lys413
Mouse Serpina1a-1816M Recombinant Mouse Serpina1a protein, His-tagged E.coli His Glu25~Lys413
Mouse SERPINA1A-001MCL Recombinant Mouse SERPINA1A cell lysate Human Cell N/A
Mouse SERPINA1A-003MCL Recombinant Mouse SERPINA1A cell lysate Human Cell N/A
Mouse SERPINA1A-002MCL Recombinant Mouse SERPINA1A cell lysate Human Cell N/A
Mouse Serpina1a-8039M-B Recombinant Mouse Serpina1a Protein Pre-coupled Magnetic Beads HEK293
Mouse Serpina1a-8039M Recombinant Mouse Serpina1a Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein

Serpina1a involved in several pathways and played different roles in them. We selected most pathways Serpina1a participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with Serpina1a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Complement and coagulation cascadesC9;Serpina1c;C4BPA;BDKRB1;PLG;C1QB;PLAUR;C8A;C1RA

Serpina1a has several biochemical functions, for example, endopeptidase inhibitor activity, glycoprotein binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Serpina1a itself. We selected most functions Serpina1a had, and list some proteins which have the same functions with Serpina1a. You can find most of the proteins on our site.

Function Related Protein
endopeptidase inhibitor activityPCSK1N;SPINK1;C3A.2;AHSG;CST3;MUG2;A2ML;SERPINA1A;Hc
glycoprotein bindingSELP;FYN;Shh;IGF2R;DNAJC5;SERPINA1D;FOXRED2;VLDLR;CALR
identical protein bindingHSD17B10;BCL2;DNMT3A;Serpina1c;PYDC3;ACTN2;CLDNG;CBY1;HCN2
peptidase inhibitor activityR3HDML;SPINK8;SERPINA3M;MUG1;KAL1B;COL7A1;PTTG2;KAL1A;Cstb
protease bindingTP53;CNTNAP2;ITGA3;CHL1;RYR1;BDKRB2;SERPINE1;INS2;TNF
protein bindingCX3CR1;RUSC2;TSHR;PTPN2;SNAP47;ATP6V1B2;LUC7L2;CDKN1A;SEC23IP
serine-type endopeptidase inhibitor activityPCSK1NL;PAPLNB;A1i3;SPINK2;WFDC13;ITIH2;SERPINB9;SPINT2;SERPINA1E

Serpina1a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Serpina1a here. Most of them are supplied by our site. Hope this information will be useful for your research of Serpina1a.

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