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SERPINC1

  • Official Full Name

    serpin peptidase inhibitor, clade C (antithrombin), member 1

  • Overview

    The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency.
  • Synonyms

    SERPINC1; serpin peptidase inhibitor, clade C (antithrombin), member 1; AT3; ATIII; MGC22579; antithrombin (aa 375-432); antithrombin III; coding sequence signal peptide antithrombin part 1; signal peptide antithrombin part 1; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1; Antithrombin-III; Serpin C1; PRO0309; OTTHUMP00000035393; serine-cysteine proteinase inhibitor clade C member 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Pig
  • Rabbit
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Human Plasma
  • Insect Cell
  • Mammalian Cell
  • Mouse Plasma
  • Plasma
  • Porcine plasma
  • Rabbit Plasma
  • Rat Plasma
  • GST
  • hFc
  • His
  • His (Fc)
  • Avi
  • Myc
  • MYC
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SERPINC1-7274H Active Recombinant Human SERPINC1, His-tagged HEK293 His Met 1-Lys 464
Human SERPINC1-856H Recombinant Human SERPINC1, His tagged Human Cell His
Human SERPINC1-474H Recombinant Human serpin peptidase inhibitor, clade C (antithrombin), member 1, His-tagged E.coli His
Human SERPINC1-2598H Recombinant Human SERPINC1, GST-tagged E.coli GST 1-259aa
Human SERPINC1-5075H Recombinant Human SERPINC1, His-tagged E.coli His
Human SERPINC1-2855HCL Recombinant Human SERPINC1 cell lysate Human Cell N/A
Human SERPINC1-5928H Recombinant Human SERPINC1 protein, His-tagged HEK293 His 1-464aa(R294H)
Human SERPINC1-8032H Native Human Plasma AntiThromblin III Human Plasma N/A
Human SERPINC1-001H Recombinant Human SERPINC1 Protein, His-tagged Insect Cell His
Human SERPINC1-5934H Recombinant Human SERPINC1 protein, hFc-tagged HEK293 hFc 1-464aa(R294H)
Human SERPINC1-2665H Active Recombinant Human SERPINC1 protein, His-tagged HEK293 His His33-Lys464
Human SERPINC1-26143TH Native Human SERPINC1 N/A
Human SERPINC1-4551H Recombinant Human SERPINC1 protein, His-tagged Insect Cell His 1-464aa
Human SERPINC1-1420H Recombinant Human SERPINC1 protein, His-GST & Myc-tagged E.coli His-GST & Myc 37-180aa
Human SERPINC1-4552H Recombinant Human SERPINC1 protein, His-tagged E.coli His 1-464aa(R294C)
Human SERPINC1-539H Recombinant Human SERPINC1 Protein, His-tagged E.coli His His33~Lys464
Human SERPINC1-1004H Recombinant Human SERPINC1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human SERPINC1-5923H Recombinant Human SERPINC1 protein, His-tagged HEK293 His 1-464aa(R294L)
Mouse Serpinc1-298M Active Native Mouse Antithrombin III Plasma N/A
Mouse SERPINC1-14956M Recombinant Mouse SERPINC1 Protein Mammalian Cell His
Mouse SERPINC1-8056M Recombinant Mouse SERPINC1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Serpinc1-5485M Native Mouse Serpin (or cysteine) Peptidase Inhibitor, Clade C (antithrombin), Member 1 Mouse Plasma N/A
Mouse SERPINC1-8056M-B Recombinant Mouse SERPINC1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Serpinc1-660M Recombinant Mouse Serpinc1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Serpinc1-541M Recombinant Mouse Serpinc1 Protein, His-tagged E.coli His His33~Asn465
Rat Serpinc1-5483R Native Rat Serpin Peptidase Inhibitor, Clade C (antithrombin), Member 1 Rat Plasma N/A
Rat Serpinc1-542R Recombinant Rat Serpinc1 Protein, His-tagged E.coli His Asp150~Arg426
Rabbit SERPINC1-5487R Native Rabbit Serpin Peptidase Inhibitor, Clade C (antithrombin), Member 1 Rabbit Plasma N/A
Bovine SERPINC1-538B Recombinant Bovine SERPINC1 Protein, His-tagged E.coli His His33~Asp465
Cynomolgus Monkey SERPINC1-1177C Active Recombinant Cynomolgus SERPINC1 Protein, His-tagged HEK293 His
Cynomolgus Monkey SERPINC1-1725CCL Recombinant Cynomolgus SERPINC1 cell lysate Human Cell N/A
Rhesus Macaque SERPINC1-4153R Recombinant Rhesus monkey SERPINC1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque SERPINC1-3970R-B Recombinant Rhesus Macaque SERPINC1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque SERPINC1-3970R Recombinant Rhesus Macaque SERPINC1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish SERPINC1-9652Z Recombinant Zebrafish SERPINC1 Mammalian Cell His
Pig SERPINC1 -50P Native Porcine Antithrombin III Porcine plasma N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SERPINC1 Related Articles
  • SERPINC1 Related Research Area

SERPINC1 involved in several pathways and played different roles in them. We selected most pathways SERPINC1 participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with SERPINC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Complement and coagulation cascadesSerpina1c;C9;PLG;C4BPB;BDKRB1;VWF;F8;F3;CFH

SERPINC1 has several biochemical functions, for example, heparin binding, protease binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SERPINC1 itself. We selected most functions SERPINC1 had, and list some proteins which have the same functions with SERPINC1. You can find most of the proteins on our site.

Function Related Protein
heparin bindingADAMTS1;NOV;REG4;SERPINC1;PGF;KAL1;SLIT2;POSTN;WISP2
protease bindingTNFRSF10A;ITGAV;FAP;ADAMTS4;PYCARD;SERPINB13;TRP53;LCN2;FADD
protein bindingALDH1A2;TAF6L;SLC9A3R1;FLG;SPEG;GSPT2;F12;ARHGEF1;RAB38
serine-type endopeptidase inhibitor activityITIH6;SERPINA10;TFPI2;PAPLN;SERPINF1;SERPINB13;A2ML1;WFDC13;SPINLW1

SERPINC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SERPINC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SERPINC1.

C1QBP; F2; PLCG1

Zeng, W; Tang, L; et al. Genetic analysis should be included in clinical practice when screening for antithrombin deficiency. THROMBOSIS AND HAEMOSTASIS 113:262-271(2015).
Luxembourg, B; D'Souza, M; et al. Prediction of the pathogenicity of antithrombin sequence variations by in silico methods. THROMBOSIS RESEARCH 135:404-409(2015).
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