SERPINC1
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Official Full Name
serpin peptidase inhibitor, clade C (antithrombin), member 1
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Overview
The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. -
Synonyms
SERPINC1; serpin peptidase inhibitor, clade C (antithrombin), member 1; AT3; ATIII; MGC22579; antithrombin (aa 375-432); antithrombin III; coding sequence signal peptide antithrombin part 1; signal peptide antithrombin part 1; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1; Antithrombin-III; Serpin C1; PRO0309; OTTHUMP00000035393; serine-cysteine proteinase inhibitor clade C member 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Bovine
- Cynomolgus Monkey
- Human
- Mouse
- Pig
- Rabbit
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Human Cell
- Human Plasma
- Insect Cell
- Mammalian Cell
- Mouse Plasma
- Plasma
- Porcine plasma
- Rabbit Plasma
- Rat Plasma
- GST
- hFc
- His
- His (Fc)
- Avi
- Myc
- MYC
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- SERPINC1 Related Articles
- SERPINC1 Related Research Area
SERPINC1 involved in several pathways and played different roles in them. We selected most pathways SERPINC1 participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with SERPINC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Complement and coagulation cascades | Serpina1c;C9;PLG;C4BPB;BDKRB1;VWF;F8;F3;CFH |
SERPINC1 has several biochemical functions, for example, heparin binding, protease binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SERPINC1 itself. We selected most functions SERPINC1 had, and list some proteins which have the same functions with SERPINC1. You can find most of the proteins on our site.
Function | Related Protein |
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heparin binding | ADAMTS1;NOV;REG4;SERPINC1;PGF;KAL1;SLIT2;POSTN;WISP2 |
protease binding | TNFRSF10A;ITGAV;FAP;ADAMTS4;PYCARD;SERPINB13;TRP53;LCN2;FADD |
protein binding | ALDH1A2;TAF6L;SLC9A3R1;FLG;SPEG;GSPT2;F12;ARHGEF1;RAB38 |
serine-type endopeptidase inhibitor activity | ITIH6;SERPINA10;TFPI2;PAPLN;SERPINF1;SERPINB13;A2ML1;WFDC13;SPINLW1 |
SERPINC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SERPINC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SERPINC1.
C1QBP; F2; PLCG1
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