SETDB1
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Official Full Name
SET domain, bifurcated 1
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Overview
The Erg-associated protein with SET domain (ESET), also known as SET-domain, bifurcated 1 (SETDB1) protein, is a member of a family of histone lysine methyltransferases, each of which contains a conserved catalytic SET domain originally identified in Dros -
Synonyms
SETDB1; SET domain, bifurcated 1; histone-lysine N-methyltransferase SETDB1; ESET; KG1T; KIAA0067; KMT1E; H3-K9-HMTase 4; lysine N-methyltransferase 1E; histone H3-K9 methyltransferase 4; ERG-associated protein with SET domain; ERG-associated protein with;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- Mammalian cells
- Sf9 Insect Cell
- Sf9 insect cells
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N His
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
SETDB1 involved in several pathways and played different roles in them. We selected most pathways SETDB1 participated on our site, such as Lysine degradation, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with SETDB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Lysine degradation | SUV420H1;EHMT1A;SETD8;SETDB1B;ALDH1B1;SUV420H2;TMLHE;SETDB2;WHSC1L1 |
Signaling pathways regulating pluripotency of stem cells | KLF4;WNT7A;FZD2;MAPK12;PIK3CA;PCGF2;PIK3R2;PCGF6;WNT9A |
SETDB1 has several biochemical functions, for example, DNA binding, histone-lysine N-methyltransferase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SETDB1 itself. We selected most functions SETDB1 had, and list some proteins which have the same functions with SETDB1. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | ZNF280A;ZKSCAN3;TA;IRX3A;NKX2.1;RABGEF1;SOX21A;ELF2A;SPTY2D1 |
histone-lysine N-methyltransferase activity | SETD7;EHMT1B;SETDB1A;SMYD3;MLL1;SETD8B;EHMT1A;WHSC1L1;EZH2 |
protein binding | PDCD1;AHCYL1;FAM54B;RUSC1;SERPINB1A;GBA;KIFC3;NCKAP1;P2RX4 |
zinc ion binding | POLE;EEA1;CA5B;BIRC8;UBR2;NR1H3;RNPEPL1;ADAM17A;BPTF |
SETDB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SETDB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SETDB1.
AKT1; DNMT3A; MBD1; TTR
- Q&As
- Reviews
Q&As (6)
Ask a questionThe current treatments for SETDB1 recombinant protein mainly include gene therapy, protein replacement therapy, and drug therapy for chromatin modification.
If the level of SETDB1 recombinant protein is abnormal, the treatment may include the use of drugs or other special treatments, depending on the condition and the doctor's recommendation.
SETDB1 recombinant protein is associated with some tumors, neurological diseases, and autoimmune diseases.
The level of SETDB1 recombinant protein can be detected by gene sequencing and protein detection methods.
The level of SETDB1 recombinant protein in pregnant women may change due to the needs of fetal growth and development, and regular monitoring is required.
Some studies have shown that SETDB1 recombinant protein may be involved in the development and progression of tumors, especially in neurological tumors and lymphomas.
Customer Reviews (3)
Write a reviewSETDB1 has shown good biocompatibility and safety in related experiments.
SETDB1 has good solubility and is easy to handle and purify.
SETDB1 is consistent and reliable, with no significant differences between batches.
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