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SETDB1

  • Official Full Name

    SET domain, bifurcated 1

  • Overview

    The Erg-associated protein with SET domain (ESET), also known as SET-domain, bifurcated 1 (SETDB1) protein, is a member of a family of histone lysine methyltransferases, each of which contains a conserved catalytic SET domain originally identified in Dros
  • Synonyms

    SETDB1; SET domain, bifurcated 1; histone-lysine N-methyltransferase SETDB1; ESET; KG1T; KIAA0067; KMT1E; H3-K9-HMTase 4; lysine N-methyltransferase 1E; histone H3-K9 methyltransferase 4; ERG-associated protein with SET domain; ERG-associated protein with;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian cells
  • Sf9 Insect Cell
  • Sf9 insect cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N His
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SETDB1-70H Active Recombinant Human SETDB1, FLAG-tagged Sf9 Insect Cell Flag
Human SETDB1-1923HCL Recombinant Human SETDB1 293 Cell Lysate HEK293 N/A
Human SETDB1-2120H Recombinant Human SETDB1 Protein (1-397 aa), GST-tagged E.coli GST 1-397 aa
Human SETDB1-675HFL Active Recombinant Full Length Human SETDB1 Protein, C-Flag-tagged Mammalian cells Flag
Human SETDB1-4766H Recombinant Human SETDB1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SETDB1-845H Recombinant Human SETDB1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SETDB1-3204H Recombinant Human SETDB1 protein, His-tagged E.coli His 1-350 aa
Human SETDB1-1986H-B Recombinant Human SETDB1 Protein Pre-coupled Magnetic Beads HEK293
Human SETDB1-12H Recombinant Human SETDB1 Protein (510-1290, end), N His-FLAG tagged Sf9 insect cells N His-GST 510-1290, end
Human SETDB1-1986H Recombinant Human SETDB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SETDB1-6717H Recombinant Human SETDB1 Protein (Met1-Ser350), N-His tagged E.coli N-His Met1-Ser350
Mouse Setdb1-5802M Recombinant Mouse Setdb1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Kit-1865 SetDB1 Chemiluminescent Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein

SETDB1 involved in several pathways and played different roles in them. We selected most pathways SETDB1 participated on our site, such as Lysine degradation, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with SETDB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Lysine degradationSUV420H1;EHMT1A;SETD8;SETDB1B;ALDH1B1;SUV420H2;TMLHE;SETDB2;WHSC1L1
Signaling pathways regulating pluripotency of stem cellsKLF4;WNT7A;FZD2;MAPK12;PIK3CA;PCGF2;PIK3R2;PCGF6;WNT9A

SETDB1 has several biochemical functions, for example, DNA binding, histone-lysine N-methyltransferase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SETDB1 itself. We selected most functions SETDB1 had, and list some proteins which have the same functions with SETDB1. You can find most of the proteins on our site.

Function Related Protein
DNA bindingZNF280A;ZKSCAN3;TA;IRX3A;NKX2.1;RABGEF1;SOX21A;ELF2A;SPTY2D1
histone-lysine N-methyltransferase activitySETD7;EHMT1B;SETDB1A;SMYD3;MLL1;SETD8B;EHMT1A;WHSC1L1;EZH2
protein bindingPDCD1;AHCYL1;FAM54B;RUSC1;SERPINB1A;GBA;KIFC3;NCKAP1;P2RX4
zinc ion bindingPOLE;EEA1;CA5B;BIRC8;UBR2;NR1H3;RNPEPL1;ADAM17A;BPTF

SETDB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SETDB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SETDB1.

AKT1; DNMT3A; MBD1; TTR

  • Q&As
  • Reviews

Q&As (6)

Ask a question
What are the treatments for SETDB1 recombinant protein? 11/24/2022

The current treatments for SETDB1 recombinant protein mainly include gene therapy, protein replacement therapy, and drug therapy for chromatin modification.

If the level of SETDB1 recombinant protein is abnormal, what should I do? 10/27/2022

If the level of SETDB1 recombinant protein is abnormal, the treatment may include the use of drugs or other special treatments, depending on the condition and the doctor's recommendation.

What diseases is SETDB1 recombinant protein associated with? 12/16/2021

SETDB1 recombinant protein is associated with some tumors, neurological diseases, and autoimmune diseases.

How can I detect the level of SETDB1 recombinant protein? 12/27/2020

The level of SETDB1 recombinant protein can be detected by gene sequencing and protein detection methods.

Does SETDB1 work in pregnant women? 10/03/2020

The level of SETDB1 recombinant protein in pregnant women may change due to the needs of fetal growth and development, and regular monitoring is required.

What is the association between SETDB1 recombinant protein and tumors? 04/14/2020

Some studies have shown that SETDB1 recombinant protein may be involved in the development and progression of tumors, especially in neurological tumors and lymphomas.

Customer Reviews (3)

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Reviews
04/12/2023

    SETDB1 has shown good biocompatibility and safety in related experiments.

    01/04/2023

      SETDB1 has good solubility and is easy to handle and purify.

      03/29/2022

        SETDB1 is consistent and reliable, with no significant differences between batches.

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