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SF3B4

  • Official Full Name

    splicing factor 3b, subunit 4, 49kDa

  • Overview

    This gene encodes one of four subunits of the splicing factor 3B. The protein encoded by this gene cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It also may be involved in the assembly of the B, C and E spliceosomal complexes. In addition to RNA-binding activity, this protein interacts directly and highly specifically with subunit 2 of the splicing factor 3B. This protein contains two N-terminal RNA-recognition motifs (RRMs), consistent with the observation that it binds directly to pre-mRNA.
  • Synonyms

    SF3B4; splicing factor 3b, subunit 4, 49kDa; splicing factor 3b, subunit 4, 49kD; splicing factor 3B subunit 4; Hsh49; SAP49; SF3b49; MGC10828; Pre mRNA splicing factor SF3b 49 kDa subunit; SAP 49; SF3b50; Spliceosomal protein; Spliceosome associated protein (U2 snRNP); Spliceosome associated protein 49; Spliceosome-associated protein (U2 snRNP); Splicing factor 3b subunit 4 49kDa; spliceosome-associated protein 49; pre-mRNA splicing factor SF3b 49 kDa subunit; pre-mRNA-splicing factor SF3b 49 kDa subunit;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SF3B4-2614H Recombinant Human SF3B4, GST-tagged E.coli GST 1-200aa
Human SF3B4-586HCL Recombinant Human SF3B4 lysate HEK293 N/A
Human SF3B4-3824H Recombinant Human SF3B4 protein, His-tagged E.coli His 1-200 aa
Mouse SF3B4-15000M Recombinant Mouse SF3B4 Protein Mammalian Cell His
Mouse SF3B4-8079M-B Recombinant Mouse SF3B4 Protein Pre-coupled Magnetic Beads HEK293
Mouse SF3B4-8079M Recombinant Mouse SF3B4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SF3B4-5352R Recombinant Rat SF3B4 Protein Mammalian Cell His
Rat SF3B4-5011R Recombinant Rat SF3B4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SF3B4-5011R-B Recombinant Rat SF3B4 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque SF3B4-4170R Recombinant Rhesus monkey SF3B4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque SF3B4-3987R-B Recombinant Rhesus Macaque SF3B4 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque SF3B4-3987R Recombinant Rhesus Macaque SF3B4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish SF3B4-9468Z Recombinant Zebrafish SF3B4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SF3B4 Related Articles

SF3B4 involved in several pathways and played different roles in them. We selected most pathways SF3B4 participated on our site, such as Gene Expression, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with SF3B4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Gene ExpressionSNRNP35;ESRRA;DNMT1;ZNF582;ZNF750;NR1D2A;CDK8;THG1L;TPRKB
Processing of Capped Intron-Containing Pre-mRNASNRNP25;CLP1;THOC4;PTBP1A;SF3A1;RNPC3;PRPF8;ZMAT5;NXF1
SpliceosomeHNRNPU;SNRPC;SARNP;SF3B4;PPIL1;DHX38;AQR;BAT1;THOC3
mRNA SplicingHNRNPA0L;TTC6;HNRNPH1;RBM5;PCBP2;SNRNP25;CD2BP2;PTBP1A;HNRNPL2
mRNA Splicing - Major PathwayHNRNPL;RBM5;SFRS3A;TXNL4A;HNRNPH1L;HNRNPR;HNRPL;HNRNPA0L;DNAJC8
mRNA Splicing - Minor PathwayPRPF8;SNRNP35;SNRNP25;PDCD7;YBX1;TXNL4A;SNRNP48;ZCRB1;SF3B4
mRNA processingSFPQ;SF3B4;OASL2;ZFP346;ADARB2;PTBP1A;LOC100862398;CLK1;HNRNPAB

SF3B4 has several biochemical functions, for example, nucleotide binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SF3B4 itself. We selected most functions SF3B4 had, and list some proteins which have the same functions with SF3B4. You can find most of the proteins on our site.

Function Related Protein
nucleotide bindingRBM27;ELAVL1;CELF6;CNOT4;DNM3A;ACTB2;SRSF5B;MYO6B;RHOGD
poly(A) RNA bindingDHX29;RPS27.1;TPR;SRPK1;FARSA;APOBEC3F;WDR6;MKRN1;RPL28
protein bindingCYGB;BCAR3;LIG4;AGTR2;MAGEA2;RPS25;PRRG2;FGF1;CLNS1A

SF3B4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SF3B4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SF3B4.

TCAF1; NCK2; SS18L1; FRK; MAPK9

van der Valk, RJP; Kreiner-Moller, E; et al. A novel common variant in DCST2 is associated with length in early life and height in adulthood. HUMAN MOLECULAR GENETICS 24:1155-1168(2015).
Petit, F; Escande, F; et al. Nager syndrome: confirmation of SF3B4 haploinsufficiency as the major cause. CLINICAL GENETICS 86:246-251(2014).
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