Sfrp2
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Official Full Name
secreted frizzled-related protein 2
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Overview
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative;Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a;potential marker for the presence of colorectal cancer. -
Synonyms
SFRP2; secreted frizzled-related protein 2; FRP 2; SARP1; SDF 5; SARP-1; sFRP-2; secreted apoptosis related protein 1; secreted apoptosis-related protein 1; FRP-2; SDF-5;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Cell & Tissue Lysates
- Chicken
- Cynomolgus
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- Human Cell
- Insect cells
- Mammalian Cell
- Mammalian cells
- C
- His
- GST
- GST|His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- Sfrp2 Related Articles
- Sfrp2 Related Research Area
Sfrp2 involved in several pathways and played different roles in them. We selected most pathways Sfrp2 participated on our site, such as Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Sfrp2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Wnt signaling pathway | FBXW11B;PLCB4;TBL1Y;SERPINF1;DAAM2;MYCB;SOX17;LRP6;WNT2B |
Sfrp2 has several biochemical functions, for example, NOT G-protein coupled receptor activity, NOT Wnt-activated receptor activity, Wnt-protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Sfrp2 itself. We selected most functions Sfrp2 had, and list some proteins which have the same functions with Sfrp2. You can find most of the proteins on our site.
Function | Related Protein |
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NOT G-protein coupled receptor activity | SFRP4;FRZB;SFRP1B;LGR5;LGR6;SFRP1;SZL;SFRP1A;SFRP2 |
NOT Wnt-activated receptor activity | SMO;SZL;SFRP1;SFRP4;FRZB;SFRP1A;SETD6;SFRP1B;SFRP2 |
Wnt-protein binding | FZD8;CTHRC1;FZD6;LRP6;EVLA;FZD3;SFRP1;SZL;GPR177 |
endopeptidase activator activity | PSME1;ADRM1;SFRP2;PSME3;PSMD14;PSME2 |
fibronectin binding | CTSS;IGFBP3;MYOC;ITGA3;LACRT;THBS1;IGFBP5B;PLEKHA2;ITGB3 |
integrin binding | EDIL3;TSPAN8;COL16A1;S1PR3;TSPAN4;L1CAM;MFGE8;COL3A1;CTGF |
metalloenzyme activator activity | |
receptor agonist activity | GREM1;VEGFA;WNT10B;WNT3;WNT2;SFRP2;WNT4;WNT1;WNT5A |
Sfrp2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Sfrp2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Sfrp2.
BUB1; PFKM; CDH1; EEF1G; CTNNA1; BMPR1A; DCC; SMAD4; DBNDD2; MLH3; RAD54B
- Q&As
- Reviews
Q&As (7)
Ask a questionSFRP2 expression plays a significant role in stem cell differentiation, contributing to tissue regeneration and repair processes.
In cardiovascular diseases, SFRP2 plays a role in processes like atherosclerosis, impacting vascular health and disease progression.
SFRP2 influences angiogenesis in tumors, affecting tumor growth and the potential for metastasis.
SFRP2 modulates Wnt signaling in cancers, with specific roles in colorectal and breast cancer development, impacting cell proliferation and migration.
SFRP2 is involved in bone metabolism, affecting bone formation and resorption in diseases like osteoporosis.
SFRP2 contributes to fibrosis in organs like the heart and liver, influencing tissue remodeling and function.
Alterations in SFRP2 expression affect adipogenesis and metabolic functions, linking it to obesity and diabetes pathologies.
Customer Reviews (3)
Write a reviewFast and affordable protein sequencing; great for identifying unknown proteins.
Robust protein-protein interaction assays; pivotal for our experiments.
High-quality protein crystallization; crucial for structural biology studies.
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