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Sfrp2

  • Official Full Name

    secreted frizzled-related protein 2

  • Overview

    This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative;Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a;potential marker for the presence of colorectal cancer.
  • Synonyms

    SFRP2; secreted frizzled-related protein 2; FRP 2; SARP1; SDF 5; SARP-1; sFRP-2; secreted apoptosis related protein 1; secreted apoptosis-related protein 1; FRP-2; SDF-5;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Chicken
  • Cynomolgus
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • Human Cell
  • Insect cells
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • GST
  • GST|His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SFRP2-299H Active Recombinant Human SFRP2 Mammalian cells N/A
Human SFRP2-509H Recombinant Human secreted frizzled-related protein 2, His-tagged E.coli His
Human SFRP2-5110H Recombinant Human SFRP2, His-tagged E.coli His
Human SFRP2-7655H Recombinant Human SFRP2 protein, His-tagged HEK293 His Leu25-Cys295
Human SFRP2-223H Recombinant Human SFRP2 Protein, GST-His-tagged E.coli GST/His
Human SFRP2-224H Recombinant Human SFRP2 protein, GST-tagged E.coli GST 156-295 aa
Human SFRP2-4481H Recombinant Human SFRP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SFRP2-4481H-B Recombinant Human SFRP2 Protein Pre-coupled Magnetic Beads HEK293
Human SFRP2-5399H Recombinant Human SFRP2 Protein (Leu25-Cys295), C-His tagged Mammalian cells C-His Leu25-Cys295
Mouse Sfrp2-223M Active Recombinant Mouse Sfrp2, His-tagged Mammalian cells His
Mouse Sfrp2-862M Recombinant Mouse Sfrp2, His tagged Human Cell His
Mouse SFRP2-2851MCL Recombinant Mouse SFRP2 cell lysate Human Cell N/A
Mouse Sfrp2-008M Recombinant Mouse Sfrp2 Protein, His-tagged Insect cells His
Mouse Sfrp2-8085M Recombinant Mouse Sfrp2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Sfrp2-8085M-B Recombinant Mouse Sfrp2 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus SFRP2-762C Recombinant Cynomolgus SFRP2 protein, His-tagged HEK293 His Leu25-Cys295
Zebrafish SFRP2-4716Z Recombinant Zebrafish SFRP2 Mammalian Cell His
Chicken SFRP2-6337C Recombinant Chicken SFRP2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Sfrp2 Related Articles
  • Sfrp2 Related Research Area

Sfrp2 involved in several pathways and played different roles in them. We selected most pathways Sfrp2 participated on our site, such as Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Sfrp2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Wnt signaling pathwayFBXW11B;PLCB4;TBL1Y;SERPINF1;DAAM2;MYCB;SOX17;LRP6;WNT2B

Sfrp2 has several biochemical functions, for example, NOT G-protein coupled receptor activity, NOT Wnt-activated receptor activity, Wnt-protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Sfrp2 itself. We selected most functions Sfrp2 had, and list some proteins which have the same functions with Sfrp2. You can find most of the proteins on our site.

Function Related Protein
NOT G-protein coupled receptor activitySFRP4;FRZB;SFRP1B;LGR5;LGR6;SFRP1;SZL;SFRP1A;SFRP2
NOT Wnt-activated receptor activitySMO;SZL;SFRP1;SFRP4;FRZB;SFRP1A;SETD6;SFRP1B;SFRP2
Wnt-protein bindingFZD8;CTHRC1;FZD6;LRP6;EVLA;FZD3;SFRP1;SZL;GPR177
endopeptidase activator activityPSME1;ADRM1;SFRP2;PSME3;PSMD14;PSME2
fibronectin bindingCTSS;IGFBP3;MYOC;ITGA3;LACRT;THBS1;IGFBP5B;PLEKHA2;ITGB3
integrin bindingEDIL3;TSPAN8;COL16A1;S1PR3;TSPAN4;L1CAM;MFGE8;COL3A1;CTGF
metalloenzyme activator activity
receptor agonist activityGREM1;VEGFA;WNT10B;WNT3;WNT2;SFRP2;WNT4;WNT1;WNT5A

Sfrp2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Sfrp2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Sfrp2.

BUB1; PFKM; CDH1; EEF1G; CTNNA1; BMPR1A; DCC; SMAD4; DBNDD2; MLH3; RAD54B

Mastri, M; Shah, Z; et al. Secreted Frizzled-related protein 2 as a target in antifibrotic therapeutic intervention. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 306:C531-C539(2014).
Tsuruta, JK; Klauber-DeMore, N; et al. Ultrasound Molecular Imaging of Secreted Frizzled Related Protein-2 Expression in Murine Angiosarcoma. PLOS ONE 9:-(2014).
  • Q&As
  • Reviews

Q&As (7)

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How does SFRP2 expression influence stem cell differentiation and regeneration in various tissues? 01/11/2022

SFRP2 expression plays a significant role in stem cell differentiation, contributing to tissue regeneration and repair processes.

What role does SFRP2 play in the development and progression of cardiovascular diseases, especially atherosclerosis? 08/22/2021

In cardiovascular diseases, SFRP2 plays a role in processes like atherosclerosis, impacting vascular health and disease progression.

What is the impact of SFRP2 on angiogenesis in the context of tumor growth and metastasis? 02/20/2021

SFRP2 influences angiogenesis in tumors, affecting tumor growth and the potential for metastasis.

How does SFRP2 interact with Wnt signaling pathways in cancer development, particularly in colorectal and breast cancers? 11/06/2020

SFRP2 modulates Wnt signaling in cancers, with specific roles in colorectal and breast cancer development, impacting cell proliferation and migration.

How does SFRP2 modulate bone formation and resorption in osteoporosis and other bone diseases? 05/24/2020

SFRP2 is involved in bone metabolism, affecting bone formation and resorption in diseases like osteoporosis.

What are the mechanisms by which SFRP2 contributes to fibrosis in organ systems like the heart and liver? 03/02/2020

SFRP2 contributes to fibrosis in organs like the heart and liver, influencing tissue remodeling and function.

How does the alteration of SFRP2 expression affect adipogenesis and metabolic processes in obesity and diabetes? 11/17/2018

Alterations in SFRP2 expression affect adipogenesis and metabolic functions, linking it to obesity and diabetes pathologies.

Customer Reviews (3)

Write a review
Reviews
11/13/2021

    Fast and affordable protein sequencing; great for identifying unknown proteins.

    04/28/2019

      Robust protein-protein interaction assays; pivotal for our experiments.

      02/20/2018

        High-quality protein crystallization; crucial for structural biology studies.

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