SGMS2
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Official Full Name
sphingomyelin synthase 2
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Overview
Sphingomyelin, a major component of cell and Golgi membranes, is made by the transfer of phosphocholine from phosphatidylcholine onto ceramide, with diacylglycerol as a side product. The protein encoded by this gene is an enzyme that catalyzes this reaction primarily at the cell membrane. The synthesis is reversible, and this enzyme can catalyze the reaction in either direction. The encoded protein is required for cell growth. Three transcript variants encoding the same protein have been found for this gene. There is evidence for more variants, but the full-length nature of their transcripts has not been determined. -
Synonyms
SGMS2; sphingomyelin synthase 2; phosphatidylcholine:ceramide cholinephosphotransferase 2; MGC26963; SMS2; SGMS 2; SM synthase; SMS 2; SMS2_HUMAN;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Cynomolgus Monkey
- Homo sapiens (Human)
- Human
- Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
- Mouse
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- Rhesus Macaque
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- In Vitro Cell Free System
- Insect cell
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- N
- mFc
- Strep II
- Involved Pathway
- Protein Function
- Interacting Protein
- SGMS2 Related Articles
SGMS2 involved in several pathways and played different roles in them. We selected most pathways SGMS2 participated on our site, such as Metabolic pathways, Metabolism, Metabolism of lipids and lipoproteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with SGMS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | CBS;CYP4A10;SAT2;AGXTB;GALNS;RDH8B;ACSM2;MSMO1;DGAT1 |
| Metabolism | APOA4B.2;CYP2W1;AKAP5;NUDT16;APOA4A;GCKR;NUDT4A;SLC25A12;ADSS |
| Metabolism of lipids and lipoproteins | ARV1;DECR1;TIAM2;ACOT10;FA2H;ACOT8;SUMF2;FABP11B;AGPAT6 |
| Sphingolipid Metabolism | SPTLC2B;SUMF2;ARSD;PPAP2D;OSBP;R05D11.9;SMPD3;GALCB;NEU3.5 |
| Sphingolipid de novo biosynthesis | COL4A3BP;SPTLC1;PPM1LA;PPM1LB;CERS3B;SGMS2;FA2H;CERS5;ACER1 |
| Sphingolipid signaling pathway | PLD1;S1PR5;TNF;GNAI1;ABCC1;S1PR2;SGPP2;CERS4;PPP2R5E |
| sphingomyelin metabolism/ceramide salvage |
SGMS2 has several biochemical functions, for example, ceramide cholinephosphotransferase activity, kinase activity, sphingomyelin synthase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SGMS2 itself. We selected most functions SGMS2 had, and list some proteins which have the same functions with SGMS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ceramide cholinephosphotransferase activity | SGMS1;SGMS2 |
| kinase activity | ADKA;FGFR1B;MOB1BA;PFKFB4L;PKN2;BMPR1AB;TNK2B;GUK1B;MAPK14B |
| sphingomyelin synthase activity | SGMS1;SGMS2 |
SGMS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SGMS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SGMS2.
Bcl7c; AKAP5; TMPO; Tnks2; Fam60a; KIF2C; CENPO
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