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SHARPIN

  • Official Full Name

    SHANK-associated RH domain interactor

  • Synonyms

    SHARPIN; SHANK-associated RH domain interactor; DKFZP434N1923; SIPL1; hSIPL1; Shank associated RH domain interacting protein; SHANK associated RH domain interactor; Shank interacting protein like 1; Shank-associated RH domain-interacting protein; Shank-interacting protein-like 1; SHRPN_HUMAN;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SHARPIN-2653H Recombinant Human SHARPIN, GST-tagged E.coli GST 1-326aa
Human SHARPIN-1601HCL Recombinant Human SHARPIN cell lysate N/A
Human SHARPIN-3420H Recombinant Human SHARPIN protein, His-tagged E.coli His 1-326 aa
Human SHARPIN-1033H Recombinant Human SHARPIN Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse SHARPIN-15087M Recombinant Mouse SHARPIN Protein Mammalian Cell His
Mouse SHARPIN-8138M-B Recombinant Mouse SHARPIN Protein Pre-coupled Magnetic Beads HEK293
Mouse Sharpin-288M Recombinant Mouse Sharpin Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse SHARPIN-8138M Recombinant Mouse SHARPIN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SHARPIN-5388R Recombinant Rat SHARPIN Protein Mammalian Cell His
Rat SHARPIN-5047R Recombinant Rat SHARPIN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SHARPIN-5047R-B Recombinant Rat SHARPIN Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SHARPIN Related Articles
  • SHARPIN Related Research Area

SHARPIN involved in several pathways and played different roles in them. We selected most pathways SHARPIN participated on our site, such as Death Receptor Signalling, Regulation of TNFR1 signaling, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with SHARPIN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Death Receptor SignallingTAB1;TAX1BP1;OTULIN;TAX1BP1B;OTUD7B;SHRPRBCK1R;CLIP3;USP2;RBCK1
Regulation of TNFR1 signalingOTUD7B;SHRPRBCK1R;FAM105B;TAX1BP1;TAX1BP1B;RNF31;RBCK1;OTULIN;USP4
Signal TransductionNEDD8L;MKS1;LPAR5A;NPSR1;METAP2B;RHOUA;CLIP3;FSTL3;ARHGAP4A
TNF signalingCLIP3;OTUD7B;TAX1BP1;OTULIN;SHRPRBCK1R;FAM105B;USP4;SHARPIN;TAX1BP1B
TNFR1-induced NFkappaB signaling pathwaySHARPIN;SHRPRBCK1R;RNF31;OTUD7B;USP4;USP2

SHARPIN has several biochemical functions, for example, identical protein binding, polyubiquitin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SHARPIN itself. We selected most functions SHARPIN had, and list some proteins which have the same functions with SHARPIN. You can find most of the proteins on our site.

Function Related Protein
identical protein bindingSUN2;CSK;PCM1;CLDND;RIPK3;PCNA;TTC32;TOPBP1;GRIN3A
polyubiquitin bindingEPS15;PSMD4A;FAM175A;FAM175B;BRE;RAD23A;SHARPIN;UBQLN4;RAD18
protein bindingAPBB1;NUDC;PRF1;GJA1;MC2R;EPN3;MIF;TMEM149;LRRIQ3
protein complex bindingEP300;TUB;LEPRE1;EPHB1;PTPRF;PPFIA2;CDK5RAP2;NCKAP1L;NRAS
zinc ion bindingPRKCBB;ZMYND11;MDM2;LIMCH1A;TEX13A;SHANK3;ZBBX;DTNA;USP13

SHARPIN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SHARPIN here. Most of them are supplied by our site. Hope this information will be useful for your research of SHARPIN.

ITGA2; ITGA5; RNF31; TNF; IKBKG; TNFAIP3; IL1A

Queisser, MA; Dada, LA; et al. HOIL-1L Functions as the PKC zeta Ubiquitin Ligase to Promote Lung Tumor Growth. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 190:688-698(2014).
Matsumoto, ML; Dong, KC; et al. Engineering and Structural Characterization of a Linear Polyubiquitin-Specific Antibody. JOURNAL OF MOLECULAR BIOLOGY 418:134-144(2012).
Renninger, ML; Seymour, RE; et al. Anti-IL5 decreases the number of eosinophils but not the severity of dermatitis in Sharpin-deficient mice. EXPERIMENTAL DERMATOLOGY 19:252-258(2010).
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