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SILV

Official Full Name

PMEL premelanosome protein
Overview

This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants.
Synonyms

P1; SI; SIL; ME20; P100; SILV; ME20M; gp100; ME20-M; PMEL17; D12S53E; melanocyte protein PMEL; melanocyte protein mel 17; silver, mouse, homolog of; melanocyte protein Pmel 17; melanosomal matrix protein17; silver locus protein homolog; melanoma-associated ME20 antigen; melanocytes lineage-specific antigen GP100;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SILV-190H	Recombinant Human SILV Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	SILV-160H	Recombinant Human Silver Homolog (Mouse)	E.coli	N/A		Inquiry
Human	SILV-2674H	Recombinant Human SILV, GST-tagged	E.coli	GST	252-593aa	$319 / 25ug
Human	SILV-1837HCL	Recombinant Human SILV 293 Cell Lysate	HEK293	N/A		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SILV Related Articles
SILV Related Research Area

SILV involved in several pathways and played different roles in them. We selected most pathways SILV participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SILV were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

SILV has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SILV itself. We selected most functions SILV had, and list some proteins which have the same functions with SILV. You can find most of the proteins on our site.

Function	Related Protein
protein binding	LGR4;SESN2;SPRY1;GRIA1;MCM3;SSX3;SYT11;GYG1;RAB25

SILV has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SILV here. Most of them are supplied by our site. Hope this information will be useful for your research of SILV.

Kitagawa, RR; Goncalves, RDR; et al. Evaluation of mutagenicity and metabolism-mediated cytotoxicity of the naphthoquinone 5-methoxy-3,4-dehydroxanthomegnin from Paepalanthus latipes Silv., Eriocaulaceae. PLANTA MEDICA 80:1417-1417(2014).

Song, U; Mun, S; et al. Effects of Three Fire-Suppressant Foams on the Germination and Physiological Responses of Plants. ENVIRONMENTAL MANAGEMENT 54:865-874(2014).

Tumor Antigens