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SIRT4

  • Official Full Name

    sirtuin 4

  • Overview

    This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
  • Synonyms

    SIRT4; sirtuin 4; sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae) , sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 4; NAD-dependent ADP-ribosyltransferase sirtuin-4; SIR2L4; sir2-like 4; sirt;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SIRT4-465H Recombinant Human SIRT4, GST-tagged E.coli GST
Human SIRT4-30846TH Recombinant Human SIRT4 E.coli N/A 314 amino acids
Human SIRT4-30844TH Recombinant Human SIRT4 E.coli N/A
Human SIRT4-4879H Recombinant Human Sirtuin 4, GST-tagged E.coli GST
Human SIRT4-2682H Recombinant Human SIRT4, His-tagged E.coli His 1-314aa
Human SIRT4-1831HCL Recombinant Human SIRT4 293 Cell Lysate HEK293 N/A
Human SIRT4-024H Recombinant Human SIRT4 Protein, GST-tagged E.coli GST 1-314
Human SIRT4-111H Recombinant Human SIRT4 Protein, GST-tagged E. coli GST 1-314
Human SIRT4-25H Recombinant Human SIRT4 protein, His-tagged E.coli His Ser28-Cys314
Human SIRT4-3477H Recombinant Human SIRT4 Protein (Ser28-Cys314), His tagged E.coli His Ser28-Cys314
Mouse SIRT4-15154M Recombinant Mouse SIRT4 Protein Mammalian Cell His
Mouse Sirt4-1377M Recombinant Mouse Sirt4 protein, His-tagged E.coli His Ser26~Pro333 (Accession # Q8R216)
Mouse SIRT4-8182M-B Recombinant Mouse SIRT4 Protein Pre-coupled Magnetic Beads HEK293
Mouse SIRT4-8182M Recombinant Mouse SIRT4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Sirt4-1378R Recombinant Rat Sirt4 protein, His-tagged E.coli His Ala60~Val255 (Accession # G3V641)
Zebrafish SIRT4-1513Z Recombinant Zebrafish SIRT4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

SIRT4 involved in several pathways and played different roles in them. We selected most pathways SIRT4 participated on our site, such as Signaling events mediated by HDAC Class I, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIRT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Signaling events mediated by HDAC Class IMXD1;GATA1;SIRT5;WDR77;SIRT7;FKBP3;NR2C1;SIRT2;PRMT5

SIRT4 has several biochemical functions, for example, NAD+ ADP-ribosyltransferase activity, NAD+ binding, NOT NAD-dependent protein deacetylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SIRT4 itself. We selected most functions SIRT4 had, and list some proteins which have the same functions with SIRT4. You can find most of the proteins on our site.

Function Related Protein
NAD+ ADP-ribosyltransferase activityTNKS2;SIRT6;GIG2P;PARP2;CHAT2;ZC3HAV1;GIG2L;GIG2E;PARP11
NAD+ bindingSIRT2;SIRT5;SIRT1;SIRT4;SIRT6;HADH;HPGD;SIRT3;ALDH1A3
NOT NAD-dependent protein deacetylase activity
biotinidase activityBTD;SIRT4
lipoamidase activity
metal ion bindingZFP354A;APEX1;FTR82;PVALB2;ZNF263;TNNI3;RNF180;ADI1;TOPAZ1
protein bindingSPAG9;VAPA;SF1;ANXA11;KIF2C;TMEM115;EGLN3;POLDIP3;GPR125

SIRT4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIRT4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIRT4.

IDE; DLAT; PDHX; SLC25A5; SLC25A6; SKP2; VWA8; NDUFS2; PMPCB

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