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SIX2

Official Full Name

SIX homeobox 2
Overview

This gene is a member of the vertebrate gene family which encode proteins homologous to the Drosophila sine oculis homeobox protein. The encoded protein is a transcription factor which, like other members of this gene family, may be involved in limb or eye development. [provided by RefSeq, Dec 2008]
Synonyms

SIX2; SIX homeobox 2; homeobox protein SIX2; sine oculis homeobox homolog 2;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse

Source

HEK293
HEK293T
Mammalian Cell
Mammalian cells

Tag

Flag
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	SIX2-1824HCL	Recombinant Human SIX2 293 Cell Lysate	HEK293	N/A	Inquiry
Human	SIX2-2729H	Recombinant Human SIX2 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK	Inquiry
Human	SIX2-1630HFL	Recombinant Full Length Human SIX2 Protein, C-Flag-tagged	Mammalian cells	Flag	Inquiry
Human	SIX2-2017H-B	Recombinant Human SIX2 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Human	SIX2-2017H	Recombinant Human SIX2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	SIX2-15162M	Recombinant Mouse SIX2 Protein	Mammalian Cell	His	Inquiry
Mouse	Six2-5889M	Recombinant Mouse Six2 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK	Inquiry
Mouse	SIX2-8186M-B	Recombinant Mouse SIX2 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	SIX2-8186M	Recombinant Mouse SIX2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Chicken	SIX2-3486C	Recombinant Chicken SIX2	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein

SIX2 involved in several pathways and played different roles in them. We selected most pathways SIX2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SIX2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

SIX2 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, protein complex binding, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SIX2 itself. We selected most functions SIX2 had, and list some proteins which have the same functions with SIX2. You can find most of the proteins on our site.

Function	Related Protein
RNA polymerase II core promoter proximal region sequence-specific DNA binding	DDIT3;ZBTB7A;NPAS4;CUX2;KCNA3;MAFB;GCFC2;KLF13;FUBP3
protein complex binding	NSF;ANKRD32;COG2;WRN;PPP4C;SH2B3;PAFAH1B1;YWHAB;CCNE1
transcription factor activity, sequence-specific DNA binding	Aff1;SALL2;TWIST2;POU1F1;EGR2A;ZNF79;HIF1AB;CBFB;SPIB
transcription factor binding	JUNB;SNF8;EPN1;HES1;HES3;GPX3;H2-AB1;FOXO4;TNFRSF10A
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	STAT3;EBF2;SIX4;MESP1;GRHL1;MTF1;POU1F1;NR5A2;FIGLA

SIX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIX2.