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SIX6

Official Full Name

SIX homeobox 6
Overview

The protein encoded by this gene is a homeobox protein that is similar to the Drosophila sine oculis gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in eye development. Defects in this gene are a cause of isolated microphthalmia with cataract type 2 (MCOPCT2).
Synonyms

SIX6; SIX homeobox 6; OPTX2, sine oculis homeobox (Drosophila) homolog 6 , sine oculis homeobox homolog 6 (Drosophila); homeobox protein SIX6; Six9; optic homeobox 2; homeodomain protein OPTX2; sine oculis homeobox homolog 6; OPTX2; MCOPCT2;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SIX6-7190H	Recombinant Human SIX Homeobox 6, His-tagged	E.coli	His	1-246aa	Inquiry
Human	SIX6-1821HCL	Recombinant Human SIX6 293 Cell Lysate	HEK293	N/A		Inquiry
Chicken	SIX6-6552C	Recombinant Chicken SIX6	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SIX6 Related Articles

SIX6 involved in several pathways and played different roles in them. We selected most pathways SIX6 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SIX6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

SIX6 has several biochemical functions, for example, DNA binding, transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SIX6 itself. We selected most functions SIX6 had, and list some proteins which have the same functions with SIX6. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	HMGN1;MIER1A;HIST1H4L;POLN;GM14479;POLD1;HIST3H3;ARID5B;ZNF563
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding	HMGA1;FOXH1;TARDBP;SIX6;NFE2L2;ZEB2;MEOX2;REL;NFATC1

SIX6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIX6 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIX6.

Mabuchi, F; Sakurada, Y; et al. Involvement of Genetic Variants Associated With Primary Open-Angle Glaucoma in Pathogenic Mechanisms and Family History of Glaucoma. AMERICAN JOURNAL OF OPHTHALMOLOGY 159:437-444(2015).

Williams, SEI; Carmichael, TR; et al. The Genetics of POAG in Black South Africans: A Candidate Gene Association Study. SCIENTIFIC REPORTS 5:-(2015).