slc18a2
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  • Official Full Name
  • solute carrier family 18 (vesicular monoamine), member 2
  • Background
  • The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton;gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity;of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is;a site of action of important drugs, including reserpine and tetrabenazine (summary by Peter et al., 1993 (PubMed;7905859)). See also SLC18A1 (MIM 193002).
  • Synonyms
  • SLC18A2; solute carrier family 18 (vesicular monoamine), member 2; VMAT2; synaptic vesicular amine transporter; SVAT; SVMT; monoamine transporter; vesicular amine transporter 2; vesicle monoamine/H+ antiporter; solute carrier family 18 member 2; vesicle m
Cat.#:SLC18A2-29830THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human SLC18A2
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Cat.#:SLC18A2-392HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human SLC18A2
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Cat.#:SLC18A2-5444RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SLC18A2 Protein
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Cat.#:SLC18A2-8135ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SLC18A2
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Involved Pathway

SLC18A2 involved in several pathways and played different roles in them. We selected most pathways SLC18A2 participated on our site, such as Synaptic vesicle cycle, Serotonergic synapse, Dopaminergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC18A2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Synaptic vesicle cycle
CPLX3; STX3; VAMP2; ATP6V0A1; ATP6V1G2; ATP6V1C1; STX1B; ATP6V1C2; ATP6V1A; ATP6V1H
Serotonergic synapse
GNAO1; HTR7; CYP2C50; SLC18A1; PTGS1; ALOX8; RAF1; GNG7; CYP2C55; PTGS2
Dopaminergic synapse
KCNJ6; GNB1; PPP3CC; GNG4; CREB3L1; GNG7; DRD1; FOS; CREB3L3; CLOCK
Parkinsons disease
NDUFA5; COX7B; SLC18A1; ATP5F1; PPIF; NDUFV2; APAF1; NDUFB3; COX5A; VDAC1
Cocaine addiction
DRD1A; DLG4; PRKACB; GRIN2C; GRM2; CREB3L2; GRIN3A; GPSM1; CREB3; RGS9
Amphetamine addiction
TH; PRKACB; PPP3CB; ATF2; CREB3; GRIN2D; PRKCA; GRIA2; FOSB; GRIN3A
Alcoholism
H2AFX; HIST1H3C; FOSB; KRAS; HIST1H2AG; HIST1H4N; HDAC6; HIST1H2BG; H2BFWT; HDAC7

Protein Function

SLC18A2 has several biochemical functions, for example, monoamine transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC18A2 itself. We selected most functions SLC18A2 had, and list some proteins which have the same functions with SLC18A2. You can find most of the proteins on our site.
Function
Related Protein
Function monoamine transmembrane transporter activity
Related Protein SLC22A1; SLC18A1; SLC18A2; SLC29A4; SLC6A4; SLC6A2; SLC6A3

SLC18A2 Related Articles

Ashe, KM; Chiu, WL; et al. Vesicular monoamine transporter-1 (VMAT-1) mRNA and immunoreactive proteins in mouse brain. NEUROENDOCRINOLOGY LETTERS 32:253-258(2011).