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SLC24A1

Official Full Name

solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
Overview

This gene encodes a member of the potassium-dependent sodium/calcium exchanger protein family. The encoded protein;plays an important role in sodium/calcium exchange in retinal rod and cone photoreceptors by mediating the extrusion;of one calcium ion and one potassium ion in exchange for four sodium ions. Mutations in this gene may play a role in;congenital stationary night blindness. Alternatively spliced transcript variants encoding multiple isoforms have been;observed for this gene.
Synonyms

SLC24A1; solute carrier family 24 (sodium/potassium/calcium exchanger), member 1; sodium/potassium/calcium exchanger 1; HsT17412; KIAA0702; NCKX; NCKX1; RODX; Na(+)/K(+)/Ca(2+) exchange protein 1; Retinal rod Na Ca+K exchanger; Retinal rod Na+/Ca+/K+ exchanger; Solute carrier family 24 (sodium/potassium/calcium exchanger) member 1; Solute carrier family 24 member 1; retinal rod Na-Ca+K exchanger; Na(+)/K(+)/Ca(2+)-exchange protein 1; CSNB1D;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Bison bison (American bison) (Bos bison)
Chicken
Human
Rat

Source

E.coli
E.coli expression system
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SLC24A1-301340H	Recombinant Human SLC24A1 protein, GST-tagged	E.coli	GST	Glu731-Leu897	Inquiry
Rat	SLC24A1-5465R	Recombinant Rat SLC24A1 Protein	Mammalian Cell	His		Inquiry
Rat	SLC24A1-5124R	Recombinant Rat SLC24A1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	SLC24A1-5124R-B	Recombinant Rat SLC24A1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Bison bison (American bison) (Bos bison)	RFL30429BF	Recombinant Full Length Bison Bison Sodium/Potassium/Calcium Exchanger 1(Slc24A1) Protein, His-Tagged	E.coli expression system	His	Full Length (1-300)	Inquiry
Chicken	SLC24A1-1164C	Recombinant Chicken SLC24A1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SLC24A1 Related Articles

SLC24A1 involved in several pathways and played different roles in them. We selected most pathways SLC24A1 participated on our site, such as Phototransduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC24A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Phototransduction	RGS9B;PDE6A;CALM;GUCA1C;RLN1;CALM3A;GNAT3;RCVRN;GC2

SLC24A1 has several biochemical functions, for example, calcium channel activity, calcium ion binding, calcium, potassium:sodium antiporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC24A1 itself. We selected most functions SLC24A1 had, and list some proteins which have the same functions with SLC24A1. You can find most of the proteins on our site.

Function	Related Protein
calcium channel activity	TRPC6A;RYR2;CACNA2D3;TRPV4;CACNA1C;TRPC2B;CACNG2A;TRPV6;CACNG1A
calcium ion binding	MYLZ3;NELL2A;PCDHB10;F7I;ABP1;RYR3;PNLIPRP1;CALU;PRKCSH
calcium, potassium:sodium antiporter activity	SLC24A4;SLC24A1;SLC24A2;SLC24A5;SLC24A4A
potassium ion binding	SLC24A4A;KCNJ11;PDXK;PKM2;PKM;PKMA;HDAC4;ATP1A1;SLC24A4
sodium ion binding	SLC24A4A;CAPN3;SLC24A5;ATP1A1;SLC24A2;SLC34A2;SCN9A;SLC24A1;PDXK
symporter activity	SLC25A22;SLC24A4;SLC24A5;SLC1A2B;SLC17A6B;SLC1A7B;SLC24A2;SLC17A7;SLC6A20A

SLC24A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC24A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC24A1.

Christopher, M; Scheetz, TE; et al. Selection of Phototransduction Genes in Homo sapiens. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 54:5489-5496(2013).

Invergo, BM; Montanucci, L; et al. A system-level, molecular evolutionary analysis of mammalian phototransduction. BMC EVOLUTIONARY BIOLOGY 13:-(2013).