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SLC27A5

  • Official Full Name

    solute carrier family 27 (fatty acid transporter), member 5

  • Overview

    The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog.
  • Synonyms

    SLC27A5; solute carrier family 27 (fatty acid transporter), member 5; bile acyl-CoA synthetase; ACSB; ACSVL6; FACVL3; FATP5; fatty acid Coenzyme A ligase; very long chain 3; FLJ22987; VLACSR; VLCS H2; VLCSH2; BA CoA ligase; BACS; BAL; Bile acid CoA ligase; Bile acyl CoA synthetase; Cholate CoA ligase; FATP 5; Fatty acid Coenzyme A ligase very long chain 3; Fatty acid transport protein 5; Solute carrier family 27 (fatty acid transporter) member 5; Solute carrier family 27 member 5; Very long chain acyl CoA synthetase homolog 2; Very long chain acyl CoA synthetase related protein; VLACS related; FATP-5; BA-CoA ligase; VLACS-related; cholate--CoA ligase; bile acid-CoA ligase; very long-chain acyl-CoA synthetase homolog 2; fatty-acid-Coenzyme A ligase, very long-chain 3; very long-chain acyl-CoA synthetase-related protein; VLCS-H2;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • E.coli
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • His|GST
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SLC27A5-1626HCL Recombinant Human SLC27A5 cell lysate N/A
Mouse Slc27a5-1770M Recombinant Mouse Slc27a5 protein, His-tagged E.coli His Glu471~Leu689 (Accession # Q4LDG0)
Mouse Slc27a5-1771M Recombinant Mouse Slc27a5 protein, His & GST-tagged E.coli His/GST Glu471~Leu689 (Accession # Q4LDG0)
Rat SLC27A5-5488R Recombinant Rat SLC27A5 Protein Mammalian Cell His
Rat Slc27a5-1772R Recombinant Rat Slc27a5 protein, His & GST-tagged E.coli His/GST Glu488~Leu690 (Accession # Q9ES38)
Rat SLC27A5-5147R Recombinant Rat SLC27A5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SLC27A5-5147R-B Recombinant Rat SLC27A5 Protein Pre-coupled Magnetic Beads HEK293
Mus musculus (Mouse) RFL5439MF Recombinant Full Length Mouse Bile Acyl-Coa Synthetase(Slc27A5) Protein, His-Tagged E.coli expression system His Full Length (1-689)
Rattus norvegicus (Rat) RFL23529RF Recombinant Full Length Rat Bile Acyl-Coa Synthetase(Slc27A5) Protein, His-Tagged E.coli expression system His Full Length (1-690)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SLC27A5 Related Articles
  • SLC27A5 Related Research Area

SLC27A5 involved in several pathways and played different roles in them. We selected most pathways SLC27A5 participated on our site, such as Bile acid and bile salt metabolism, Bile secretion, Insulin resistance, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC27A5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Bile acid and bile salt metabolismAKR1C4;AKR1C6;BRSK2;ACOT8;SLC27A5;CYP8B2;AKR1C21;Alb;SCP2B
Bile secretionSLC9A3;SLC5A1;ADCY9;ATP1B1;SLCO1B2;NCEH1;ABCB11;CYP3A4;ABCC2
Insulin resistancePDPK1;RPS6KA3B;G6PC2;PPP1R3A;RPS6KA3A;INS2;NFKBIAA;MAPK8B;IRS2
Metabolic pathwaysMDH2;PAPSS2B;UGT2B15;PLD3;PIGB;AMPD1;TKTL2;COX6B1;GLDC
MetabolismMED9;CA5B;DPYD;CYP51A1;DIO2;CYP19A1;MED29;CTHL;CSPG5B
Metabolism of lipids and lipoproteinsCEPT1;ALOX5AP;MTF1;ACOT11A;YAP1;MED22;APOA5;ALOX5B.3;TMEM195
PPAR signaling pathwayACOX2;ACSL4B;PPARDB;Scd1;APOA5;RXRA;FABP7;SCP2;ANGPTL4
Primary bile acid biosynthesisCYP46A1.2;ACOX2;AKR1C4;SCP2;SLC27A5;CYP46A1.3;AMACR;CYP46A1.4;CH25H

SLC27A5 has several biochemical functions, for example, ATP binding, cholate-CoA ligase activity, fatty acid transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC27A5 itself. We selected most functions SLC27A5 had, and list some proteins which have the same functions with SLC27A5. You can find most of the proteins on our site.

Function Related Protein
ATP bindingPL10;PI4KB;DHX9;DHX38;UBE2R2;SRPK1B;DDX6;EPHB3A;UCKL1A
cholate-CoA ligase activity
fatty acid transporter activitySLC27A2;SLC27A4;SLC27A1A;SLC27A1B;SLC27A5
long-chain fatty acid-CoA ligase activitySLC27A1B;ACSL5;SLC27A1A;SLC27A3;SLC27A4;SLC27A2;ACSBG1;ACSL1;ACSL3
protein complex bindingPLK2;TELO2;GIT1;SLC27A5;ANKRD54;BAX;VPS28;BCAP31;RBM10
very long-chain fatty acid-CoA ligase activitySLC27A1B;SLC27A2;SLC27A1A;SLC27A3;ACSL4;SLC27A5;SLC27A4;ACSBG1

SLC27A5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC27A5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC27A5.

Hadzic, N; Bull, LN; et al. Diagnosis in bile acid-CoA: Amino acid N-acyltransferase deficiency. WORLD JOURNAL OF GASTROENTEROLOGY 18:3322-3326(2012).
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