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SLC46A1

Official Full Name

solute carrier family 46 (folate transporter), member 1
Overview

This gene encodes a transmembrane proton-coupled folate transporter protein that facilitates the movement of folate and antifolate substrates across cell membranes, optimally in acidic pH environments. This protein is also expressed in the brain and choroid plexus where it transports folates into the central nervous system. This protein further functions as a heme transporter in duodenal enterocytes, and potentially in other tissues like liver and kidney. Its localization to the apical membrane or cytoplasm of intestinal cells is modulated by dietary iron levels. Mutations in this gene are associated with autosomal recessive hereditary folate malabsorption (HFM) disease. HFM is characterized by folate deficiency due to reduced intestinal folate absorption and subsequent anemia, hypoimmunoglobulinemia, and recurrent infections. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Synonyms

SLC46A1; solute carrier family 46 (folate transporter), member 1; solute carrier family 46, member 1; proton-coupled folate transporter; HCP1; heme carrier protein 1; MGC9564; PCFT; proton coupled folate transporter; G21; PCFT/HCP1; solute carrier family 46 member 1;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
Insect Cell
Mammalian Cell

Tag

8His
MBP,Flag
His
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SLC46A1-2773H	Recombinant Human SLC46A1, His-tagged	E.coli	His	1-100aa	$319 / 25ug
Human	SLC46A1-0916H	Recombinant Human SLC46A1 Protein (E2-P459), 8×His-MBP, Flag tagged	Insect Cell	8His-MBP,Flag	E2-P459	Inquiry
Mouse	SLC46A1-15460M	Recombinant Mouse SLC46A1 Protein	Mammalian Cell	His		Inquiry
Mouse	SLC46A1-8382M-B	Recombinant Mouse SLC46A1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	SLC46A1-8382M	Recombinant Mouse SLC46A1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	SLC46A1-5544R	Recombinant Rat SLC46A1 Protein	Mammalian Cell	His		Inquiry
Rat	SLC46A1-5203R	Recombinant Rat SLC46A1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	SLC46A1-5203R-B	Recombinant Rat SLC46A1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	SLC46A1-10617Z	Recombinant Zebrafish SLC46A1	Mammalian Cell	His		Inquiry
Chicken	SLC46A1-4507C	Recombinant Chicken SLC46A1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SLC46A1 Related Articles

SLC46A1 involved in several pathways and played different roles in them. We selected most pathways SLC46A1 participated on our site, such as Iron uptake and transport, Metabolism, Metabolism of folate and pterines, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC46A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Iron uptake and transport	ATP6V1G3;TFR1B;FTH1B;SLC46A1;TCIRG1;ABCG2D;MFSD7B;FLVCR1;SLC22A17
Metabolism	HAS1;CYP3C4;GLIPR1;ALOX5B.2;ADA;MMADHC;NUDT1;ADAL;TYMP
Metabolism of folate and pterines	SLC25A32;SLC25A32A;SLC46A1;SLC25A32B
Metabolism of vitamins and cofactors	SLC46A1;GPHNA;ELA2;SLC2A3;NAMPT;CYB5R3;SLC19A2;SLC5A6A;CD320
Metabolism of water-soluble vitamins and cofactors	SLC25A32;SLC23A2;CTRB1;SLC5A6A;ELA2L;CBLC-1;ELA2;MOCOS;SLC46A1
Mineral absorption	MT1H;MT1A;ATP1A2;STEAP2;FTH1;SLC34A2;ATP1B1;TRPM6;MT1
Transmembrane transport of small molecules	MATE4;RHCGL1;SLC35B4;SLC26A3.1;ATP1A1A.3;AQP8A.1;BEST1;SLC38A5B;SLC24A4A
Vitamin digestion and absorption	SLC5A6;SLC23A1;SLC52A3;SLC19A1;SLC19A2;CUBN;RBP2;SLC46A1;SCARB1

SLC46A1 has several biochemical functions, for example, folic acid binding, folic acid transporter activity, NOT heme transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC46A1 itself. We selected most functions SLC46A1 had, and list some proteins which have the same functions with SLC46A1. You can find most of the proteins on our site.

Function	Related Protein
folic acid binding	FTCD;SLC19A1;DAAM2;GNMT;DHFR;FOLR1;FOLR2;MTHFS;FOLR3
folic acid transporter activity	FOLR1;SLC25A32;SLC19A1;FOLR2;SLC46A1;DAAM2;SLC19A2
NOT heme transporter activity
hydrogen ion transmembrane transporter activity	ATP6V1C1A;ATP6V0CA;ATP6V1B2;SLC36A1;ATP6V1B1;ATP6V1F;ATP6V1AA;ATP5IB;ATP6V0A1A
methotrexate transporter activity	SLC19A1;SLC46A1

SLC46A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC46A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC46A1.

b3xyc5_sollc

Gonen, N; Assaraf, YG; et al. The Obligatory Intestinal Folate Transporter PCFT (SLC46A1) Is Regulated by Nuclear Respiratory Factor 1. JOURNAL OF BIOLOGICAL CHEMISTRY 285:33602-33613(2010).

Laftah, AH; Latunde-Dada, GO; et al. Haem and folate transport by proton-coupled folate transporter/haem carrier protein 1 (SLC46A1). BRITISH JOURNAL OF NUTRITION 101:1150-1156(2009).

Unal, ES; Zhao, RB; et al. N-linked glycosylation and its impact on the electrophoretic mobility and function of the human proton-coupled folate transporter (HsPCFT). BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1778:1407-1414(2008).

Qiu, A; Min, SH; et al. Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 293:C1669-C1678(2007).