slc46a1
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  • Official Full Name
  • solute carrier family 46 (folate transporter), member 1
  • Background
  • This gene encodes a transmembrane proton-coupled folate transporter protein that facilitates the movement of folate and antifolate substrates across cell membranes, optimally in acidic pH environments. This protein is also expressed in the brain and choroid plexus where it transports folates into the central nervous system. This protein further functions as a heme transporter in duodenal enterocytes, and potentially in other tissues like liver and kidney. Its localization to the apical membrane or cytoplasm of intestinal cells is modulated by dietary iron levels. Mutations in this gene are associated with autosomal recessive hereditary folate malabsorption (HFM) disease. HFM is characterized by folate deficiency due to reduced intestinal folate absorption and subsequent anemia, hypoimmunoglobulinemia, and recurrent infections. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
  • Synonyms
  • SLC46A1; solute carrier family 46 (folate transporter), member 1; solute carrier family 46, member 1; proton-coupled folate transporter; HCP1; heme carrier protein 1; MGC9564; PCFT; proton coupled folate transporter; G21; PCFT/HCP1; solute carrier family 46 member 1
Cat.#:SLC46A1-2773HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SLC46A1, His-tagged
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Cat.#:SLC46A1-15460MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SLC46A1 Protein
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Cat.#:SLC46A1-5544RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SLC46A1 Protein
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Cat.#:SLC46A1-4507CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SLC46A1
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Cat.#:SLC46A1-10617ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SLC46A1
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Involved Pathway

SLC46A1 involved in several pathways and played different roles in them. We selected most pathways SLC46A1 participated on our site, such as Iron uptake and transport, Metabolism, Metabolism of folate and pterines, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC46A1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Iron uptake and transport
FTH1A; TFA; SLC22A17; TFR1B; MFSD7B; TCIRG1; CP; SLC46A1; FLVCR1; ATP6V1G3
Metabolism
COQ7; AQP1A.1; ARSI; ADSL; CPTP; FAM36A; SLC26A1; DSEL; SLC25A1; LOC100686744
Metabolism of folate and pterines
SLC25A32A; SLC46A1; SLC25A32B; SLC25A32
Metabolism of vitamins and cofactors
MMADHC; LOC100686744; GPHN; SLC46A1; CYB5R3; PDZD11; CTRC; SLC23A2; CTRB1; SLC5A6A
Metabolism of water-soluble vitamins and cofactors
SLC25A16; KCNG4; SLC2A3; TCN1; SLC25A32B; SLC25A32; SLC19A2; PDZD11; SLC46A1; CTRC
Mineral absorption
MT1A; Trf; MT1E; SLC46A1; ATP7A; SLC26A6; SLC34A2; CYBRD1; FTL; MT1M
Transmembrane transport of small molecules
ATP1A1A.3; SLC6A1A; SCNN1D; ATP1A1A.2; SLC41A1; ATP1A1A.5; SLC8A2A; SLC39A3; TRPV3; CLCN4-2
Vitamin digestion and absorption
TCN2; MMACHC; BTD; APOA1; APOB; FOLH1; SLC52A3; LMBRD1; SLC19A2; RBP2

Protein Function

SLC46A1 has several biochemical functions, for example, folic acid binding, folic acid transporter activity, NOT heme transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC46A1 itself. We selected most functions SLC46A1 had, and list some proteins which have the same functions with SLC46A1. You can find most of the proteins on our site.
Function
Related Protein
Function folic acid binding
Related Protein GNMT; FOLR2; DHFR; DMGDH; FOLR1; FTCD; SLC46A1; SLC19A1; FOLR3; DAAM2
Function folic acid transporter activity
Related Protein SLC19A2; DAAM2; SLC19A1; SLC25A32; FOLR2; SLC46A1; FOLR1
Function NOT heme transporter activity
Related Protein SLC46A1
Function hydrogen ion transmembrane transporter activity
Related Protein ATP5H; ATP5I; ATP5G3B; ATP6V0D2; ATP6V0A1B; ATP6V0A2B; ATPV0E2; ATP6V0E; ATP5G3; ATP6V0CB
Function methotrexate transporter activity
Related Protein SLC19A1; SLC46A1

Interacting Protein

SLC46A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC46A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC46A1.
b3xyc5_sollc

SLC46A1 Related Articles

Gonen, N; Assaraf, YG; et al. The Obligatory Intestinal Folate Transporter PCFT (SLC46A1) Is Regulated by Nuclear Respiratory Factor 1. JOURNAL OF BIOLOGICAL CHEMISTRY 285:33602-33613(2010).
Laftah, AH; Latunde-Dada, GO; et al. Haem and folate transport by proton-coupled folate transporter/haem carrier protein 1 (SLC46A1). BRITISH JOURNAL OF NUTRITION 101:1150-1156(2009).
Unal, ES; Zhao, RB; et al. N-linked glycosylation and its impact on the electrophoretic mobility and function of the human proton-coupled folate transporter (HsPCFT). BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1778:1407-1414(2008).
Qiu, A; Min, SH; et al. Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 293:C1669-C1678(2007).