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SLC5A5

Official Full Name

Solute Carrier Family 5 (sodium iodide symporter), Member 5
Overview

The sodium/iodide symporter (NIS), also known as solute carrier family 5, member 5 (SLC5A5) is a protein that in humans is encoded by the SLC5A5 gene. The sodium/iodide symporter is a transmembrane glycoprotein with a molecular weight of 87 kDa and 13 transmembrane domains, which transports two sodium cations (Na+) for each iodide anion (I–) into the the cell. NIS mediated uptake of of iodide into follicular cells of the thyroid gland is the first step in the synthesis of thyroid hormone.
Synonyms

SLC5A5; solute carrier family 5 (sodium iodide symporter), member 5; NIS; TDH1; Sodium/iodide cotransporter; Na(+)/I(-) cotransporter; Sodium-iodide symporter; Solute carrier family 5 member 5; Na(+)/I(-) symporter; Na(+)/I(-)-symporter;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SLC5A5-2778H	Recombinant Human SLC5A5 protein, His-tagged	E.coli	His	539-643 aa	$319 / 25ug
Human	SLC5A5-82HCL	Recombinant Human SLC5A5 cell lysate, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Human	SLC5A5-1207H	Recombinant Human SLC5A5 protein, His & GST-tagged	E.coli	His/GST	Ser547~Leu643 (Accession # Q92911)	Inquiry
Zebrafish	SLC5A5-5534Z	Recombinant Zebrafish SLC5A5	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SLC5A5 Related Articles

SLC5A5 involved in several pathways and played different roles in them. We selected most pathways SLC5A5 participated on our site, such as Thyroid hormone synthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC5A5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Thyroid hormone synthesis	TG;DUOXA2;TTF2;TSHB;PRKCA;ATP1A3;LRP2;PDIA4;CREB3L1

SLC5A5 has several biochemical functions, for example, iodide transmembrane transporter activity, sodium:iodide symporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC5A5 itself. We selected most functions SLC5A5 had, and list some proteins which have the same functions with SLC5A5. You can find most of the proteins on our site.

Function	Related Protein
iodide transmembrane transporter activity	SLC5A5;SLC26A4
sodium:iodide symporter activity

SLC5A5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC5A5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC5A5.

Spitzweg, C; Bible, KC; et al. Advanced radioiodine-refractory differentiated thyroid cancer: the sodium iodide symporter and other emerging therapeutic targets. LANCET DIABETES & ENDOCRINOLOGY 2:830-842(2014).

Li, ZH; Chen, L; et al. Alteration of thyroid hormone levels and related gene expression in Chinese rare minnow larvae exposed to mercury chloride. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 38:325-331(2014).