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SMARCE1

Official Full Name

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Overview

The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart.
Synonyms

SMARCE1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1; BAF57; BRG1-associated factor 57; chromatin remodeli;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SMARCE1-2807H	Recombinant Human SMARCE1, GST-tagged	E.coli	GST	C-term-323aa	$319 / 25ug
Human	SMARCE1-1667HCL	Recombinant Human SMARCE1 293 Cell Lysate	HEK293	N/A		Inquiry
Mouse	Smarce1-5963M	Recombinant Mouse Smarce1 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Rat	SMARCE1-5615R	Recombinant Rat SMARCE1 Protein	Mammalian Cell	His		Inquiry
Rat	SMARCE1-5274R	Recombinant Rat SMARCE1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	SMARCE1-5274R-B	Recombinant Rat SMARCE1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	SMARCE1-4339R	Recombinant Rhesus monkey SMARCE1 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	SMARCE1-4155R	Recombinant Rhesus Macaque SMARCE1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	SMARCE1-4155R-B	Recombinant Rhesus Macaque SMARCE1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	SMARCE1-11446Z	Recombinant Zebrafish SMARCE1	Mammalian Cell	His		Inquiry
Chicken	SMARCE1-1479C	Recombinant Chicken SMARCE1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

SMARCE1 involved in several pathways and played different roles in them. We selected most pathways SMARCE1 participated on our site, such as Androgen receptor signaling pathway, Chromatin modifying enzymes, Chromatin organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMARCE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Androgen receptor signaling pathway	DAXX;KAT5;SMARCE1;KAT7B;CARM1;HMGB2A;SVILA;CCDC102A;CMTM2A
Chromatin modifying enzymes	EPC1;ATXN7;SUZ12A;CARM1;KDM1B;KANSL2;PHF15;SMARCB1B;PRMT5
Chromatin organization	BRPF3;SMARCD3;DMAP1;SUDS3;COPRS;KDM6B;SAP30;KDM4C;MTA3
RMTs methylate histone arginines	WDR77;PBRM1;SMARCB1A;SMARCC1;SMARCB1;SMARCB1B;SMARCA4;PBRM1L;SMARCA2
Regulation of Androgen receptor activity	NR2C2;TRIM24;HOXB13;SENP1;SMARCA2;KAT7;GATA2;SRY;NR0B1
TNF-alpha/NF-kB Signaling Pathway	LRPPRC;DCAF7;KPNA6;RNF25;KIAA1967;RNF216;PFDN2;COPS3;TRPC4AP

SMARCE1 has several biochemical functions, for example, N-acetyltransferase activity, RNA binding, contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMARCE1 itself. We selected most functions SMARCE1 had, and list some proteins which have the same functions with SMARCE1. You can find most of the proteins on our site.

Function	Related Protein
N-acetyltransferase activity	MBOAT4;CML2;Acnat1;AANAT;SMARCE1;SAT1A.2;NAA40;AANAT1;NAT10
RNA binding	DPPA5;DIS3;RBM4B;EXOSC7;RBM48;PABPC1L2A;RNASEL4;EYA1;HNRPKL
contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding	GATAD2B;HDAC2;SMARCE1;RBBP4;MTA2;MBD3;ACTB;SMARCC2;SMARCA4
contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding	SMARCC1;HDAC1;RBBP4;ACTL6A;GATAD2B;CHD4;SMARCB1;MTA2;MBD3
chromatin binding	MED12;SHMT2;PARP1;JUB;SOX14;TOP2B;BAP1;ORC1L;POLG
ligand-dependent nuclear receptor binding	SMARCD3;ARID1A;TRIM24;PROX1;ISL1;NCOR2;SRA1;NCOA3;NR1H4
contributes_to nucleosomal DNA binding	RBBP4;HDAC2;MTA2;HDAC1;CHD4;SMARCA4;SMARCC2;ACTL6A;SMARCC1
protein N-terminus binding	TGFB1;ALOX5AP;RPA2;ERCC6;SMARCC1;NCOA3;SMARCE1;ACTN4;SNF8
protein binding	MAGEA4;MAGEA1;ECE2;HTATIP2;AMHR2;DOK3;GOPC;SHMT1;MAP2K2
transcription coactivator activity	KAT2A;PSMD9;NRIP1;SUPT3H;NFE2;TFAP2B;USP16;VGLL2;MED13

SMARCE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMARCE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMARCE1.

CEP63; KIFC3; BRMS1; ARID2; MEOX2; 285622