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SMG1

Official Full Name

SMG1 phosphatidylinositol 3-kinase-related kinase
Overview

This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternatively spliced transcript variants have been described, but their full-length nature has yet to be determined. [provided by RefSeq, Mar 2013]
Synonyms

SMG1; SMG1 phosphatidylinositol 3-kinase-related kinase; ATX; LIP; 61E3.4; serine/threonine-protein kinase SMG1; lambda-interacting protein; PI-3-kinase-related kinase SMG-1; lambda/iota protein kinase C-interacting protein; smg-1 homolog, phosphatidylinositol 3-kinase-related kinase;

Species	Cat.#	Product name	Source (Host)	Tag	Price
Mouse	SMG1-15622M	Recombinant Mouse SMG1 Protein	Mammalian Cell	His	Inquiry
Mouse	SMG1-8478M	Recombinant Mouse SMG1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	SMG1-8478M-B	Recombinant Mouse SMG1 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Zebrafish	SMG1-4986Z	Recombinant Zebrafish SMG1	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
SMG1 Related Articles

SMG1 involved in several pathways and played different roles in them. We selected most pathways SMG1 participated on our site, such as mRNA surveillance pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
mRNA surveillance pathway	PABPC1;SMG6;NXT1;CASC3;PPP1CBL;PABPN1L;SMG5;PPP1CAB;ALYREF

SMG1 has several biochemical functions, for example, ATP binding, kinase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMG1 itself. We selected most functions SMG1 had, and list some proteins which have the same functions with SMG1. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	STK38A;FYNA;RUNX2A;SBK1;MAP2K3;ULK1A;IGHMBP2;PRKX;RYK
kinase activity	SGMS1;CAMK1DB;CDKN1D;PI4KAB;SBK1;FGGY;GSK3AB;LMTK2;SRC
metal ion binding	ZNF362A;TOE1;ELP3;PON3;PMM1;KLK1B4;ZBTB22;EXTL3;ROCK2B
nucleotide binding	EXOSC10;ARL4CA;DDX19;TRNAU1APA;HNRPDL;SRSF6B;ACTA1A;CAMK1GA;PSMC1A
phosphotransferase activity, alcohol group as acceptor	FAM20B;ADKB;PI4KAB;POMK;G6PC;GKUP;PI4KAA;PI4KAP2;SMG1
poly(A) RNA binding	PTPN1;MARK2;FNDC3B;MAGOH;RPL7;MYO18A;CHERP;CCBL2;DHX36
protein dimerization activity	HER4.3;SLC4A11;NEUROG3;SIM1B;ID2;MAX;HES2;ANO7;MYC
protein serine/threonine kinase activity	PHKG1B;PRKCI;MTOR;SPEG;RAF1;CLK3;CSNK2A1;CDK15;ALPK1
transferase activity	ADKA;SULT1D1;GALNTL4;SAT1A.2;AGXTB;B3GNT5B;OASL1;JAK2A;GGCTB

SMG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMG1.

Cho, H; Han, S; et al. SMG1 regulates adipogenesis via targeting of staufenl-mediated mRNA decay. BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS 1829:1276-1287(2013).

Henderson-Smith, A; Chow, D; et al. SMG1 Identified as a Regulator of Parkinson's Disease-Associated alpha-Synuclein through siRNA Screening. PLOS ONE 8:-(2013).