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SMURF1

Official Full Name

SMAD specific E3 ubiquitin protein ligase 1
Overview

Members of the transforming growth factor-beta (TGFB) family signal through type I and type II serine/threonine-kinase receptors,Which in turn activate the SMAD signaling pathway. Bone morphogenetic protein (BMP) receptors target SMAD1, SMAD5, and SMAD8,Whereas receptors for activin and TGFB (e.g., ACVR1 and TGFBR1, respectively) target SMAD2 and SMAD3. Phosphorylation of these receptor-regulated SMADs induces their association with the common-partner SMAD, SMAD4. Smurf1, a HECT domain E3 ubiquitin ligase, regulates cell polarity and protrusive activity and is required to maintain the transformed morphology and motility of a tumor cell. Atypical protein kinase C-zeta (PKC2), an effector of the Cdc42/Rac1-PAR6 polarity complex, recruits Smurf1 to cellular protrusions,Where it controlled the local level of RhoA. Smurf1 thus links the polarity complex to degradation of RhoA in lamellipodia and filopodia to prevent RhoA signaling during dynamic membrane movements.
Synonyms

SMURF1; SMAD specific E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase SMURF1; KIAA1625; hSMURF1; E3 ubiquitin ligase SMURF1; Smad-specific E3 ubiquitin ligase 1; Smad ubiquitination regulatory factor 1; SMAD-specific E3 ubiquitin-protein ligase 1;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell
Sf9 Insect Cell

Tag

Flag
GST
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	SMURF1-45H	Recombinant Human SMURF1 protein, GST-tagged	E.coli	GST	Inquiry
Human	SMURF1-467H	Recombinant Human SMURF1, FLAG-tagged	Sf9 Insect Cell	Flag	Inquiry
Human	SMURF1-1647HCL	Recombinant Human SMURF1 293 Cell Lysate	HEK293	N/A	Inquiry
Human	SMURF1-1344H	Recombinant Human SMURF1 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK	Inquiry
Mouse	Smurf1-5984M	Recombinant Mouse Smurf1 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK	Inquiry
Rhesus Macaque	SMURF1-4353R	Recombinant Rhesus monkey SMURF1 Protein, His-tagged	Mammalian Cell	His	Inquiry
Rhesus Macaque	SMURF1-4169R	Recombinant Rhesus Macaque SMURF1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rhesus Macaque	SMURF1-4169R-B	Recombinant Rhesus Macaque SMURF1 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Zebrafish	SMURF1-264Z	Recombinant Zebrafish SMURF1	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
SMURF1 Related Signal Pathway

SMURF1 involved in several pathways and played different roles in them. We selected most pathways SMURF1 participated on our site, such as Ubiquitin mediated proteolysis, Endocytosis, TGF-beta signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMURF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Ubiquitin mediated proteolysis	FBXO4;CUL1B;UBR5;PIAS1;PARK2;CUL5;NEDD4;XIAP;CUL3A
Endocytosis	STAMBPA;TGFBR1B;RAB11FIP1;CYTH4;DAB2;CYTH3;GRK7B;ARPC4;CHMP2A
TGF-beta signaling pathway	FSTA;NBL1;SMAD9;BMPR1A;BMP2;LEFTY2;NOG;MAPK1;CUL1B

SMURF1 has several biochemical functions, for example, I-SMAD binding, R-SMAD binding, activin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMURF1 itself. We selected most functions SMURF1 had, and list some proteins which have the same functions with SMURF1. You can find most of the proteins on our site.

Function	Related Protein
I-SMAD binding	SMAD1;AXIN2;TGFB1I1;AXIN1;SMURF1;SMAD6;SMAD7;SMAD2;CTNNB1
R-SMAD binding	PPM1A;FOXH1;CTNNB1;PMEPA1;TRIM33;MYOCD;AXIN1;MEN1;PAX6
activin binding	ACVR2B;FSTL3;ACVRL1;SMURF1;ACVR1;ENG;FST;FKBP1A;SMAD7
ligase activity	SIAH2L;TRIM17;SMURF1;MDM2;TTLL2;NEURL1B;RTCD1;RNF123;DTX3
phospholipid binding	ESYT1;OSBPL1A;ABCG1;PACSIN1;SPTBN2;SYT14;NSMAF;VAMP2;SNCA
protein binding	KRTAP10-4;TNFSF12;C1orf65;E4F1;HSPH1;FAM195A;USP28;SULT4A1;RBMY1B
ubiquitin protein ligase activity	ARIH1L;TRIM32;HLTF;HERC2;TRIM24;ITCH;RNF24;RNF121;UBE2V2
ubiquitin-protein transferase activity	LNX2B;UBE2T;FBXL6;RNF187;FBXW2;TRAF4B;MIB1;PDZRN3B;IRAK1

SMURF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMURF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMURF1.

FBXL15; PLEKHO1; PSME3; SMAD1; KLF2; UBA1; UBE2N; UBE2V1