SMURF2
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Official Full Name
SMAD specific E3 ubiquitin protein ligase 2
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Overview
SMURF2 has been shown to interact with Mothers against decapentaplegic homolog 7, SCYE1, SMURF1, Mothers against decapentaplegic homolog 3, Ubiquitin C, Mothers against decapentaplegic homolog 1 and Mothers against decapentaplegic homolog 2. -
Synonyms
SMURF2; SMAD specific E3 ubiquitin protein ligase 2; E3 ubiquitin-protein ligase SMURF2; hSMURF2; E3 ubiquitin ligase SMURF2; SMAD ubiquitination regulatory factor 2; SMAD-specific E3 ubiquitin-protein ligase 2; MGC138150; DKFZp686F0270;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Sf9 Insect Cell
- Yeast
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- SMURF2 Related Articles
- SMURF2 Related Research Area
- SMURF2 Related Signal Pathway
SMURF2 involved in several pathways and played different roles in them. We selected most pathways SMURF2 participated on our site, such as Ubiquitin mediated proteolysis, Endocytosis, TGF-beta signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMURF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | SOCS3B;UBA1;FANCL;UBE3B;FLJ11011L;UBE2N;WWP2;CDC26;UBE2NA |
| Endocytosis | ARPC3;ACAP3B;ERBB4A;CHMP4B;MVB12A;CYTH1;CDC42L2;SNX4;SNX12 |
| TGF-beta signaling pathway | ROCK1;BMP2;SMAD1;INHBB;RBX1;INHBAB;NOG3;ID2A;BMP5 |
SMURF2 has several biochemical functions, for example, SMAD binding, identical protein binding, ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SMURF2 itself. We selected most functions SMURF2 had, and list some proteins which have the same functions with SMURF2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SMAD binding | COL5A2;EID2;SKOR2;SKI;SKIL;PML;SKOR1A;SKOR1B;SMAD2 |
| identical protein binding | STK4;ATXN3;RAD52;CST3;CLDN16;KCNRG;S100A4;PICK1;CCL3 |
| ligase activity | UBE2NB;BRCA1;ZNRF2B;TRIM6;TRIM68;CDC34A;CBL;MGRN1;RTCD1 |
| protein binding | TOMM70A;MMACHC;GFM2;MYO10;TBX5A;IL15RA;AP5S1;DUSP1;SUMO2 |
| transforming growth factor beta receptor binding | GDF11;TGFBRAP1;LEFTY2;BMP6;MSTN;BMP8B;LFT2;BMP3;GDF5 |
| ubiquitin protein ligase activity | ITCH;CDC34;ZSWIM2;CBLL1;UBE2V2;RNF217;RNF14;ARIH2;RNF2 |
| ubiquitin-protein transferase activity | FBXL6;WDSUB1;RNF20;FBXO2;UBE2D3;ARIH2;FBXL14;BRAP;TRIM62 |
SMURF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMURF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMURF2.
SMAD2; RNF11; SMAD3
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