smyd3
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  • Official Full Name
  • SET and MYND domain containing 3
  • Synonyms
  • SMYD3; SET and MYND domain containing 3; zinc finger, MYND domain containing 1, ZMYND1, ZNFN3A1; SET and MYND domain-containing protein 3; KMT3E; bA74P14.1 (novel protein); zinc finger, MYND domain containing 1; zinc finger MYND domain-containing protein 1; zinc finger protein, subfamily 3A (MYND domain containing), 1; ZMYND1; ZNFN3A1; bA74P14.1; FLJ21080; MGC104324
Cat.#:SMYD3-2062HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human SMYD3 Protein, MYC/DDK-tagged
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Cat.#:SMYD3-1634HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human SET And MYND Domain Containing 3, GST-tagged
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Cat.#:SMYD3-263HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMYD3 protein, GST-tagged
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Cat.#:SMYD3-312HTag:His/Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human SMYD3 Protein, His & FLAG-tagged
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Cat.#:SMYD3-666HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human SET And MYND Domain Containing 3, His-tagged
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Cat.#:SMYD3-920HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human SMYD3, GST tagged
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Cat.#:SMYD3-15657MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SMYD3 Protein
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Cat.#:SMYD3-4354RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SMYD3 Protein, His-tagged
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Cat.#:SMYD3-3525ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SMYD3
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Cat.#:SMYD3-2506HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human SMYD3 cell lysate
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Cat.#:SMYD3-698HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human SMYD3 cell lysate
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Cat.#:Kit-1868Tag:
Source (Host):Species:
Product nameSMYD3 Homogeneous Assay Kit
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Involved Pathway

SMYD3 involved in several pathways and played different roles in them. We selected most pathways SMYD3 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, PKMTs methylate histone lysines, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMYD3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chromatin modifying enzymes
KDM5A; SUZ12B; SUZ12A; TADA1; HMG20B; JMJD6; KIAA1267; EPC1; MSL2B; SMARCA4
Chromatin organization
BRPF3; PHF17; ING3; ENY2; KDM1B; TAF6L; JMJD6; ING5; BRPF1; ARID1A
PKMTs methylate histone lysines
RBBP5; ASH2L; DPY30; PRDM16; SUZ12B; SMYD3; SMYD2A; ATF7IP; SUZ12A; SUZ12

Protein Function

SMYD3 has several biochemical functions, for example, RNA polymerase II core binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMYD3 itself. We selected most functions SMYD3 had, and list some proteins which have the same functions with SMYD3. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II core binding
Related Protein KIAA1967; RECQL5; ZNF326; CDC73; KIAA1530; CTR9; SMYD2; SMYD2A; WACA; AGO1
Function RNA polymerase II core promoter sequence-specific DNA binding
Related Protein ZFP335; NR4A2; SMYD3; WBP2; ZNF277; EP300; STAT5A; H3F3A; SFPI1; TP53
Function RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
Related Protein SMYD3; NCOA2; VAX1; HSF2; ZC3H8; VAX2; ZNF350; HSF1
Function histone-lysine N-methyltransferase activity
Related Protein KMT2A; SETD1BA; SETDB1B; SMYD2B; SETD7; EHMT2; AAAS; EHMT1; PRDM7; SMYD3
Function metal ion binding
Related Protein CYP2X10.2; ING5B; TP63; RIOK1; ITGB2; ZFP184; BTR22; CYP2J5; NEK1; XPA

Interacting Protein

SMYD3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMYD3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMYD3.
DDOST; MEST; FAR1; NDUFAB1; NFYB; PBX2; CAMK2B; ZNF57; H3F3C; VANGL1; TRIT1; CYP39A1; q9wmx2-pro_0000037551; polg_hcvh; CDC37

SMYD3 Related Articles

Xu, GL; Liu, GL; et al. The Histone Methyltransferase Smyd2 Is a Negative Regulator of Macrophage Activation by Suppressing Interleukin 6 (IL-6) and Tumor Necrosis Factor alpha (TNF-alpha) Production. JOURNAL OF BIOLOGICAL CHEMISTRY 290:5414-5423(2015).
Spellmon, N; Holcomb, J; et al. Structure and Function of SET and MYND Domain-Containing Proteins. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 16:1406-1428(2015).