snrpa1
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  • Official Full Name
  • small nuclear ribonucleoprotein polypeptide A
  • Background
  • SNRPA1, also known as U2 small nuclear ribonucleoprotein A, is a component of the U2 snRNP that forms a complex with U2 snRNP B (U2B). Together, U2 snRNP A and U2 snRNP B form a complex that binds to the U2 snRNA hairpin IV. The configuration of this U2 The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which binds the 5' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregulates itself by polyadenylation inhibition of its own pre-mRNA via dimerization and has been implicated in the coupling of splicing and polyadenylation.
  • Synonyms
  • SNRPA1; small nuclear ribonucleoprotein polypeptide A; U2 small nuclear ribonucleoprotein A; Lea1; RU2A_HUMAN; U2 small nuclear ribonucleoprotein polypeptide A; U2 snRNP A; SNRPA; U1 small nuclear ribonucleoprotein A; Mud1; U1 A; U1A; U1 snRNP A; U1 snRNP-specific protein A; U1 small nuclear RNP-specific A; U1-A
Cat.#:SNRPA1-2848HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SNRPA1, GST-tagged
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Cat.#:SNRPA1-29599THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SNRPA1, His-tagged
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Cat.#:SNRPA1-4830HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Small Nuclear Ribonucleoprotein Polypeptide A', His-tagged
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Cat.#:SNRPA-15691MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SNRPA Protein
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Cat.#:SNRPA1-951CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus SNRPA1 Protein, His-tagged
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Cat.#:SNRPA1-4376RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SNRPA1 Protein, His-tagged
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Cat.#:SNRPA-4375RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SNRPA Protein, His-tagged
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Cat.#:SNRPA1-1263CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SNRPA1
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Cat.#:SNRPA-10070ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SNRPA
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Cat.#:SNRPA1-1769ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SNRPA1
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Cat.#:SNRPA1-1618HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SNRPA1 293 Cell Lysate
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Cat.#:SNRPA-1619HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SNRPA 293 Cell Lysate
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Involved Pathway

SNRPA1 involved in several pathways and played different roles in them. We selected most pathways SNRPA1 participated on our site, such as Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with SNRPA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Spliceosome
U2SURP; HSPA1B; SFRS3B; SNRNP70; LSM4; SARNP; TRA2B; ISY1-RAB43; PRPF40A; DDX39B

Protein Function

SNRPA1 has several biochemical functions, for example, U2 snRNA binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SNRPA1 itself. We selected most functions SNRPA1 had, and list some proteins which have the same functions with SNRPA1. You can find most of the proteins on our site.
Function
Related Protein
Function U2 snRNA binding
Related Protein SNRPA1; ISG20; TROVE2; PRPF8
Function poly(A) RNA binding
Related Protein NOP16; HSP90AA1; LARP1; TUFM; C7orf50; DYNC1LI1; PUS7; APEX1; MRPS23; ZNF207
Function protein binding
Related Protein ZKSCAN17; RPS20; MCRS1; PPIC; PAIP2; NBR1; C4orf26; A1CF; ABCD1; INHA

Interacting Protein

SNRPA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SNRPA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SNRPA1.
SNRPA; VCAM1; SNRPB2; TOP1; TRDMT1; SMNDC1; HNF1A; HLA-B; VHL; MAGEA6; CASP4; ARF6

SNRPA1 Related Articles

Wood, JD; Liu, SM; et al. Anti-Enteric Neuronal Antibodies and the Irritable Bowel Syndrome. JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY 18:78-85(2012).
Kaneko, Y; Suwa, A; et al. Clinical associations with autoantibody reactivities to individual components of U1 small nuclear ribonucleoprotein. LUPUS 19:307-312(2010).