socs2
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  • Official Full Name
  • suppressor of cytokine signaling 2
  • Background
  • Accumulating evidence demonstrates that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules Termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family have been recognized, they are SOCS-1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways.
  • Synonyms
  • SOCS2; suppressor of cytokine signaling 2; CIS2; Cish2; SOCS 2; SSI 2; SSI2; STAT induced STAT inhibitor 2; STATI2; CIS-2; STAT induced STAT inhibitor-2; STAT-induced STAT inhibitor 2; STAT-induced STAT inhibitor-2; cytokine-inducible SH2 protein 2; suppressor of cytokine signaling-2; SSI-2; SOCS-2
Cat.#:Socs2-690RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Socs2 Protein, His-tagged
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Cat.#:SOCS2-2871HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SOCS2, His-tagged
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Cat.#:SOCS2-5664RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SOCS2 Protein
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Cat.#:SOCS2-4401RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SOCS2 Protein, His-tagged
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Cat.#:SOCS2-6109CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SOCS2
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Cat.#:SOCS2-6428ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SOCS2
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Cat.#:SOCS2-1581HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SOCS2 293 Cell Lysate
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Involved Pathway

SOCS2 involved in several pathways and played different roles in them. We selected most pathways SOCS2 participated on our site, such as Jak-STAT signaling pathway, Insulin signaling pathway, Prolactin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOCS2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Jak-STAT signaling pathway
LEPA; IRX1; IL2RGA; CRFB4; Il23a; RNF207B; IL10RA; IL3; IL20RB; IFNA1
Insulin signaling pathway
SOCS2; FBP1A; RPTOR; PPP1CB; HK2; FOXO1A; BRAF; PCK1; PHKA2; MAP2K1
Prolactin signaling pathway
SHC1; MAP2K2; STAT1; NRAS; NEK3; PIK3CB; CSH; SOCS3; SOCS7; PPIB
Type II diabetes mellitus
MAPK10; HKDC1; SOCS3; IRS1; INS-IGF2; MAPK3; IRS4; SOCS1; PKM; PIK3R2

Protein Function

SOCS2 has several biochemical functions, for example, JAK pathway signal transduction adaptor activity, SH3/SH2 adaptor activity, growth hormone receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SOCS2 itself. We selected most functions SOCS2 had, and list some proteins which have the same functions with SOCS2. You can find most of the proteins on our site.
Function
Related Protein
Function JAK pathway signal transduction adaptor activity
Related Protein SOCS2; SH2B2
Function SH3/SH2 adaptor activity
Related Protein SRC; NCK2; HSH2D; SH2D3A; SH2D3C; LAT; CHN1; ARHGAP1; PTPN11; SHB
Function growth hormone receptor binding
Related Protein GH1; JAK1; JAK2; TYK2; Gh; SOCS2
Function insulin-like growth factor receptor binding
Related Protein SOCS2; INSR; IGF2; SOCS1; YWHAH; INS; SHC1; IGF1; INSL4; Ren1
Function protein binding
Related Protein PPP4R1; C12orf50; EML2; TESK2; CCNA2; SUB1; PRC1; BRCA1; SLC41A3; CIAO1

Interacting Protein

SOCS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOCS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOCS2.
TCEB1; MET; KIT; PLA2G1B; EPOR; BMI1; ARFIP2; TPD52; Tceb1; GHR

SOCS2 Related Articles

Hu, J; Lou, DH; et al. LPS Regulates SOCS2 Transcription in a Type I Interferon Dependent Autocrine-Paracrine Loop. PLOS ONE 7:-(2012).
Gilli, F; Navone, ND; et al. Loss of Braking Signals During Inflammation A Factor Affecting the Development and Disease Course of Multiple Sclerosis. ARCHIVES OF NEUROLOGY 68:879-888(2011).